Neuropathy improvers containing nitrogenous compounds as the active ingredient

ABSTRACT

A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. 
                         
[Here, G represents G1 shown below
 
                         
R 4  represents, hydrogen atoms and acyl groups, W represents single bonds and alkylenes, m represents 0 or 1, R 5  and R 6  represent hydrogen atoms, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, aromatic hydrocarbon groups and heterocyclic groups, and R 7  represents hydrogen atoms, acyl groups and alkoxycarbonyl groups. A 2  represents, single bonds, —O—, —NR 3 —, and —S(═O) n —, A 1  and A 3  represent single bonds, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, heterocyclic groups and phenylene groups, and A 4  represents single bonds, carbonyl groups and aliphatic hydrocarbon groups. R 1  and R 2  represent hydrogen atoms, alkyl groups, cycloalkyl groups, phenyl groups and heterocyclic groups. The previously mentioned functional groups may be substituted.]

TECHNICAL FIELD

The present invention relates to an agent for the remedy of neuraldamage wherein the active ingredient is a nitrogen-containing compoundhaving a prostacyclin analog structure and an amido group or an aminogroup at the extremity of the α-chain, as well as pharmaceuticalcompositions thereof. In addition, the invention relates to anitrogen-containing compound having a prostacyclin analog structure andan amino group at the extremity of the α-chain, as well as saltsthereof.

TECHNICAL BACKGROUND

In the nervous system, neurons perform their function once they haveformed a network through synapses between neurons by extending neurites(either axon or dendrite). In addition, such intercellular communicationallows the cells to maintain their own existence through a mutualexchange of transmitters and nutritional factors. Therefore, even if theneurons themselves do not suffer fatal damage, if the neural network isdamaged, neural functions decrease and, further, may lead to the deathof the neurons themselves. Such neural network damage is thought to bewhat takes place first, not only in cases such as in external injurieswhere axons are disrupted, but also in many disorders causing neuraldamage, or in the surroundings of the damaged site. Therefore, a drugagent having a capability such as restoring neural network damage isthought to be both a drug agent capable of controlling the cellulardeath of neurons and an extremely active drug agent for the remedy ofmany disorders due to neural damage as well as lesion of nerves due toexternal injuries.

The following may be cited as disorders caused by neural damage: 1)Neuro-degenerative disorders such as Alzheimer's disease, Pick'sdisease, Lewy body disease, Parkinson's disease, Huntington's chorea,spinocerebellar degeneration and amyotrophic lateral sclerosis, 2)demyelinating disorders such as acute disseminated encephalomyelitis andmultiple sclerosis, 3) metabolic disorders such as brain lipidosis andWilson's Disease, 4) infectious disorders such as meningitis andCreutzfeld-Jacob disease, 5) peripheral neural disorders such aspolyneuritis and Guillain-Barre Syndrome, 6) cerebrovascular disordersuch as cerebral infarction and transient ischemia, 7) nervous disorders(neuropathies) associated with diabetes and renal diseases and 8) braintumors.

Among the previously mentioned disorders which cause neural damage,Alzheimer's disease is the most representative, and constitutes aserious social issue together with the increase in the population of theelderly. In the past, the drug agents used for treating Alzheimer'sdisease could be roughly divided into those classified as activators ofbrain circulation and metabolism, and those classified as cholinergicnervous system activators. However, the activities of these drug agentsare not sufficient.

In other words, activators of brain circulation and metabolism are drugsthat are used to treat cerebrovascular damage and their after-effects,do not aid recovery directly from neural damage and therefore have a lowefficacy against dementia which is the core disorder in Alzheimer'sdisease. In addition, activators of the cholinergic nervous system weredeveloped based on the pathological findings that Alzheimer's diseasepatients had notable damage in the cholinergic nervous system. However,in Alzheimer's disease, cholinergic nervous systems are actually not theonly ones that are damaged, therefore, the effects of such drugs arethought to be limited.

Given the situation, development of drugs based on novel drug effectsfor the treatment of Alzheimer's disease are strongly in demand. Amongothers, drug agents having an activity such as restoring neural networkdamage, as mentioned above, are anticipated to display extremely highefficacy for the treatment of Alzheimer's disease, if put into practicalapplication.

In the past, for the development of drugs for the treatment ofAlzheimer's disease, the models used for evaluating the drug's efficacyat the animal level were mainly models where the cholinergic nervoussystem was specifically damaged by methods such as administration ofscoporamine or electric destruction, or models where damage was producedby cerebral ischemia or hypoxic stress due to carbon dioxide. Althoughmany of these evaluation systems are reasonable as evaluation systemsfor the activators of the cholinergic nervous system or activators ofbrain circulation and metabolism, they are pathogenetically andpathologically distant from actual Alzheimer's disease, and aretherefore not suited to the evaluation of novel drugs for the treatmentof Alzheimer disease.

One important characteristic of Alzheimer's disease is the formation ofsenile plaques in the brain. β-amyloid proteins, which are the mainconstituents of these senile plaques, agglutinate in the brain to formamyloids and while being deposited in the brain tissue, exhibit theirneurotoxicity, which is thought to be the main cause for Alzheimer'sdisease. Based on this, an animal model of Alzheimer's disease was made,wherein a mini-osmotic pump is implanted under the dorsal skin of a rat,for a continuous intracerebroventricular administration of β-amyloidproteins to lower the ability of learning and memory (NeuroscienceLetters, vol. 170, pp. 63–66, 1994). In this model, deposition of theβ-amyloid proteins could be recognized in the periphery of the cerebralventricle. However, no clear neural cell death could be observed,therefore, there is a high possibility that the disorder of learning andmemory observed in this model are due to damage in the neural network.Therefore, this model is an extremely rational system for screening andevaluating novel drugs for the treatment of Alzheimer's disease, and atthe same time, is an adequate system for screening and evaluating noveldrugs for the treatment of neural lesion due to a whole range ofdiseases causing neural damage, or due to injuries.

On the other hand, prostaglandin (PG) compounds are known to havemultiple physiological activities such as strong platelet aggregationinhibition activity, vasodilatation and the associated hypotensionactivities, gastric acid secretion inhibition activity, smooth musclecontraction activity, cell protection activity, and diuretic activity.Based on such physiological activities, a number of attempts have beenmade to develop medicine from natural PG present in vivo, or from PGderivatives synthesized to serve as its agonists, and some of theseattempts actually reached the market.

Prostacyclin, which is a PG, has the structure represented by theformula below (PGI2),

(in the formula, the numbers are identification numbers for the carbonatoms in prostacyclin) which is a substance containing a structurecalled α-chain comprising the carbon chain from 1 to 7, and a structurecalled ω-chain from carbon 13 to 20. In vivo it is known as a localhormone, mainly made in the vascular endothelium, and attempts were madeto use its strong physiological activities, for example, plateletaggregation inhibition, smooth muscle contraction, hypotension, gastricacid secretion inhibition, peripheral vasodilatation andbronchodilatation, to provide it directly as a medicine (P. J. Lewis, J.O. Grady, Clinical Pharmacology of Prostaglandin).

However, because a prostacyclin molecule has a highly hydrolizableenol-ether bond, it is easily inactivated under neutral or acidicconditions, which makes it problematic in compounds to be used asmedicines. Therefore, synthetic research was carried out on a compoundhaving a prostacyclin analog structure, displaying the same activity asprostacyclin and being chemically stable (Synthesis, 1984, p. 449). Inother words, this objective was achieved mainly by modifying thebicyclo[3.3.0]octane ring structure of from carbon 5 to 12 inprostacyclin. For example, the oxygen atoms bridging position 6 to 9 maybe substituted with a methene group (—CH═) to synthesize the compound9(O)-methano-Δ^(6(9α))-prostaglandin I₁ (Isocarbacyclin) indicated bythe formula below (Isocarbacyclin),

which is a compound having a prostacyclin analog structure fullysatisfying the chemical stability (Japanese patent publication Sho.59-210044). This compound displayed biological activities comparable tothose of prostacyclin such as strong platelet aggregation inhibitoryactivity and vasodilatory-hypotensive activities (Japanese patentpublication Sho. 59-210044 and Japanese patent publication Sho.61-197518).

In the past, development of PG compounds to be used as medicine wasmainly carried out in the field of obstetrics and gynecology,circulation or digestion. In the nerve field, there are no examples ofthese compounds commercialized as medicine, although there have beenreports on the possibility of using PG compounds in nervous systems.

The following are known examples describing in particular the effect ofcompounds having a prostacyclin analog structure and which remedy neuraldamage: 1) in Japanese patent publication Sho. 61-129146, a compoundhaving an isocarbacyclin analog structure was used for the prevention ofor the treatment of the brain for disorders such as cerebral oxygendeficiency, 2) in Japanese patent publication Hei. 2-167227, a compoundhaving an isocarbacyclin analog structure was used for the treatment ofdiabetic neuropathy, 3) in Japanese patent publication Hei. 8-245498,Japanese patent publication Hei. 10-101610, Japanese patent publicationHei. 11-5764 and patent No. EP-911314, a compound having anisocarbacyclin analog structure was used as a drug for the treatment ofcentral nervous system disease, via the prostacyclin receptor of thecentral nervous system 4) in patent No. WO89/03387,2,5,6,7-tetranor-4,8-inter-m-phenylene PGI₂ derivative was used as adrug for the treatment of cerebral ischemia 5) in Japanese patentpublication Hei. 2-262519, beraprost was used for the treatment ofdiabetic neuropathy, 6) in Japanese patent publication Sho. 63-141927,treatment and prevention of cerebral thrombosis and cerebral infarction.

In the previously mentioned examples, however, the efficacy is describedfor compounds with a carboxyl group at position 1 of the prostacyclin oran ester thereof. Only in the compounds having a prostacyclin analogstructure described in the above mentioned 6), a compound having aprostacyclin analog structure wherein the carboxyl group at position 1is substituted by an amide group is described. However, there is noconcrete description related to its pharmacological activity. Therefore,the usability of a compound having a prostacyclin analog structurewherein the carboxyl group at position 1 is substituted with an amidegroup, as a drug for the remedy of neural damage, was not known.

On the other hand, most of the compounds of the past known to have aprostaglandin analog activity, are compounds having a prostacyclinanalog structure with, at position 1, a carboxyl group which is thoughtto be important for expressing the activity, or a chemical structurethat can be easily substituted with a carboxyl group in vivo. Therefore,there are only few publicly known substances having a prostacyclinanalog structure with an amino group at the extremity of the α-chain.For example, the compound below, described in the (East) German patentNo. DD266102,

(in the formula, the symbol

indicates the E or the Z configuration with respect to the attacheddouble-bond and TBDMS represents a t-butyl-dimethylsilyl group).However, it is positioned as a synthetic intermediate, and a descriptionof its activity is not available.

In addition, in the U.S. patent publication No. U.S. Pat. No. 4,226,984,the compounds having the structure indicated below

and their substituted versions on the (o-chain are described as having astimulatory effect on smooth muscles. However, no concrete example isgiven.

In addition, in the Japanese patent publication Sho. 54-117450, asynthesis of the compound having the structure below

is described. However, no description on its activity is given.

In addition, in the Japanese patent publication Sho. 62-67046, thecompounds of the scheme below

(in the scheme, THP represents tetrahydropyrane-2-yl group and TBDMSrepresents a t-butyl-dimethylsilyl group.) and their substitutedversions on the ω-chain are described. However, no description of theiractivity is given.

In addition, in the Japanese patent publication Hei. 9-67285, the 4compounds below

are described. However, no description of their activity is given.

In addition, in the detailed description of WO00/24727, only adescription of the anti-helicobacter activity is given, of a derivativeof the compound having an amino group at the extremity of the α-chain,comprising the compound indicated by the formula below,

and being a compound with a prostacyclin analog structure.

Therefore, most of the compounds having a prostacyclin analog structurewith an amino group at the extremity of the α-chain were novelsubstances with no known usability.

DISCLOSURE OF THE INVENTION

The problem to be solved by the present invention is to provide a novelagent for the remedy of neural damage which can act against disordersdue to neural damage, or against neural lesions due to externalinjuries. Here, disorders caused by neural damage, or disorders causedby neural lesions due to external injuries may be cited as disorders inwhich the agent for the remedy of neural damage of the present inventioncan be used. Concretely, the following may be cited as disorders causedby neural damage: 1) Neuro-degenerative disorders such as Alzheimer'sdisease, Pick's disease, Lewy body disease, Parkinson's disease,Huntington's chorea, spinocerebellar degeneration and amyotrophiclateral sclerosis, 2) demyelinating disorders such as acute disseminatedencephalomyelitis and multiple sclerosis, 3) metabolic disorders such asbrain lipidosis and Wilson's Disease, 4) infectious disorders such asmeningitis and Creutzfeld-Jacob disease, 5) peripheral neuropathies suchas polyneuritis and Guillain-Barre Syndrome, 6) cerebrovascular disordersuch as cerebral infarction and transient ischemia, 7) nervous disorders(neuropathies) associated with diabetes and renal diseases and 8) braintumors.

In addition, when attempting to develop PG compounds to serve as amedicine in the cerebral nerve field, two problems have to beconsidered. The first problem is that the diversity of activities thatPG compound has may cause adverse events. In order to solve thisproblem, it is necessary to use compounds that are active asspecifically on the cerebral nervous system as possible, with lowinfluences on other parts such as circulatory organs. The second problemis that, in contrast to the vascular system in peripheral organs, in thevascular system of the brain, the vascular endothelial cells areassociated by tight junctions, which results in a limitation of thedelivery of substances from the circulating blood to the parenchymaltissue of the brain, that is, a so-called blood brain barrier exists.Therefore, in order to develop drug agents for the cerebral nervoussystem, it is necessary to obtain drugs with a high permeability acrossthe blood brain barrier.

After performing extensive research on the above-mentioned problemsemploying neuroid cells to evaluate the promotion activity on theneurite outgrowth, an evaluation system using an animal model forAlzheimer type dementia wherein β-amyloid protein is continuouslyinjected, and a system to evaluate the decrease of blood pressure, theinventors of the present application found that the nitrogen-containingcompound in the formula (1) shown below, having a prostacyclin analogstructure and an amido group or an amino group at the extremity of theα-chain, had the activity of promoting the neurite outgrowth, as well asthe activity of remedying disorders of learning and memory provoked bythe β-amyloid protein. In addition, the above-mentioned compounds showedthat they have only a low influence on the peripheral circulatorysystem, that their activity displays a high specificity for the brain,and that the above mentioned compound has a high permeability acrossblood brain barriers, allowing the present invention to be completed.

In other words, the present invention is an agent for the remedy ofnerve disorders having as the active ingredient the compound representedby the formula (1) shown below.

[In Formula (1), the symbol

represents a single bond or a double bond.

G represents one functional group chosen from the group consisting ofthe Formulae (G1), (G2), (G3), (G4), (G5), (G6), (G7), (G8), (G9),(G10), (G11) and (G12) shown below.

(In Formula G1), Formula (G2), Formula (G3), Formula (G4), Formula (G5),Formula (G6), Formula (G7), Formula (G8), Formula (G9), Formula (G10),Formula (G11) and Formula (G12),the symbol

represents the site of linkage with A¹.

R⁴ represents a hydrogen atom, an acyl group having 2 to 10 carbonatoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl groupor a functional group forming the acetal bond together with the oxygenatom bonded to R⁴.

W represents a single bond, —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —CH═CH—,—CH═CHCH₂—, —C═C— or —C═CCH₂—.

-   -   m may be either 0 or 1. However, when W is a single bond, m is        equal to 1.    -   R⁵ and R⁶ are either identical or different and, either        represents one functional group chosen from the following        items 1) to 5), i.e.,

-   1) a hydrogen atom,

-   2) a substituted or an unsubstituted aliphatic hydrocarbon group    having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents, substituted or unsubstituted alicyclic hydrocarbon    group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having    1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents), substituted or    unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms    (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine    atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having    1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms,    aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to    10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, cyano group, nitro group, sulfide group having 1 to 6    carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents), and, substituted or unsubstituted heterocyclic group    having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the    cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom,    chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy    group having 1 to 4 carbon atoms, aryloxy group having 6 to 10    carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents) may be cited as substituents),

-   3) a substituted or an unsubstituted alicyclic hydrocarbon group    having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon    atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon    atoms, carbamoyl group having 1 to 15 carbon atoms, amino group    having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon    atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group    having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group    having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon    atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited    as substituents),

-   4) a substituted or an unsubstituted aromatic hydrocarbon group    having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),

-   5) a substituted or an unsubstituted heterocyclic group having 1 to    4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),

-   or, when R⁵ and R⁶ are bonded to each other, they represent a    substituted or an unsubstituted alicyclic hydrocarbon chain having 4    to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine    atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,    alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to    10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, an acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents).

R⁷ represents a hydrogen atom, an acyl group having 2 to 10 carbonatoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group,an alkoxycarbonyl group having 2 to 5 carbon atoms, a sulfonyl grouphaving 1 to 8 carbon atoms, a functional group forming the acetal bondtogether with the oxygen atom bound to R⁷, or, when R⁷ and R⁵ are bondedto each other, it represents one portion of the bond forming thecarbonyl group together with the carbon atom bonded to R⁵ and the oxygenatom bonded to R⁷.

A² represents a single bond, a Formula (A2A) shown below, a Formula(A2B) shown below or a Formula (A2C) shown below.

(In the formula, R³ represents a hydrogen atom, an alkyl group having 1to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms.)

(In the formula, n represents 0, 1, or 2.)

A¹ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges G and A² through an identical    atom or through different atoms, and chosen from: an aliphatic    hydrocarbon group having 1 to 3 carbon atoms, an alicyclic    hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group    having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a    phenylene group.

A³ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges A² and A⁴ through an identical    atom or through different atoms, and chosen from: an aliphatic    hydrocarbon group having 1 to 3 carbon atoms, an alicyclic    hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group    having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a    phenylene group.

A⁴ represents either of the items 1) to 4) below

-   1) a single bond-   2) a carbonyl group-   3) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which    bridges the nitrogen atom, bonded to R¹ and R², and A³ through an    identical atom or through different atoms.-   4) when A⁴ and R¹ are bonded to each other, a functional group    forming a 5 to 8 membered ring together with the nitrogen atom they    are bonded to (when A⁴ or R¹ and the nitrogen atom they are bonded    to are bonded through a double bond, R² represents the bond between    A⁴ or R¹ and the nitrogen atom.)

However, in the combination of A¹, A², A³ and A⁴, A¹, A², A³ and A⁴ maynot simultaneously represent bonds. In addition, when A² represents oneof the Formula (A2A), Formula (A2B) or Formula (A2C), A² and thenitrogen atom bonded to R¹ and R² must be bonded with more than twocarbon atoms in between.

R¹ and R² are either identical or different, and either represent onefunctional group chosen from the following items 1) to 7), i.e.,

-   1) a hydrogen atom,-   2) a substituted or an unsubstituted alkyl group having 1 to 10    carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine    atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms,    aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7    to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms,    sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl    group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl    group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group    having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon    atoms, phenyl group, and, heterocyclic group (containing 1 to 4    oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as    substituents),-   3) a substituted or an unsubstituted cycloalkyl group having 3 to 8    carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine atom,    chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy    group having 1 to 4 carbon atoms, aryloxy group having 6 to 10    carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents),-   4) a substituted or an unsubstituted phenyl group (alkyl group    having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl group    having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group    having 2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon    atoms, amino group having 0 to 14 carbon atoms, acylamino group    having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, cyano group, nitro group, sulfide group having 1 to 6    carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents),-   5) a substituted or an unsubstituted heterocyclic group (containing    1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   6) an acyl group having 1 to 10 carbon atoms when A⁴ is not a    carbonyl group,-   7) a sulfonyl group having 1 to 8 carbon atoms when A⁴ is not a    carbonyl group (however, when either R¹ or R² represents a sulfonyl    group having 1 to 8 carbon atoms, the other may be neither an acyl    group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8    carbon atoms), or, when R¹ and R² are bonded together, they    represent a functional group forming a cyclic amino group having 4    to 8 carbon atoms together with the nitrogen atom they are bonded to    (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group    having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents)].

In addition, the present invention is a nitrogen-containing compoundrepresented by Formula (2) below or a salt thereof.

[In Formula (2), the symbol

represents a single bond or a double bond. G represents one functionalgroup chosen from the group consisting of the Formulae (G1), (G2), (G3),(G4), (G5), (G6), (G7), (G8), (G9), (G10), (G11) and (G12) shown above.(In Formula (G1), Formula (G2), Formula (G3), Formula (G4), Formula(G5), Formula (G6), Formula (G7), Formula (G8), Formula (G9), Formula(G10), Formula (G11) and Formula (G12), the symbol

represents the site of linkage with A¹⁰.

R⁴, W, m, R⁵, R⁶ and R⁷ have the same definitions as above.

A²⁰ represents a single bond, a Formula (A2A) shown below, a Formula(A2B) shown below or a Formula (A2C) shown below.

(In the formula, R³ represents a hydrogen atom, an alkyl group having 1to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms.)

(In the formula, n represents 0, 1, or 2.)

A¹⁰ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges G and A²⁰ through an identical    atom or through different atoms, and chosen from: an aliphatic    hydrocarbon group having 1 to 3 carbon atoms, an alicyclic    hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group    having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a    phenylene group.

A³⁰ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges A²⁰ and A⁴⁰ through an identical    atom or through different atoms, and chosen from: an aliphatic    hydrocarbon group having 1 to 3 carbon atoms, an alicyclic    hydrocarbon group having 3 to 8 carbon atoms, a heterocyclic group    having 1 or 2 oxygen atoms, nitrogen atoms, or sulfur atoms, and a    phenylene group.

A⁴⁰ represents any of the items 1) to 3) below

-   1) a single bond-   2) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which    bridges the nitrogen atom, bonded to R¹⁰ and R²⁰, and A³⁰ through an    identical atom or through different atoms.-   3) when A⁴⁰ and R¹⁰ are bonded to each other, a functional group    forming a 5 to 8 membered ring together with the nitrogen atom they    are bonded to (when A⁴⁰ or R¹⁰ and the nitrogen atom they are bonded    to are bonded through a double bond, R²⁰ represents the bond between    A⁴⁰ or R¹⁰ and the nitrogen atom.)

However, in the combination of G, A¹⁰, A²⁰, A³⁰, and A⁴⁰, when Grepresents the Formula (G1), and either of A¹⁰ or A³⁰ is a phenylenegroup, A²⁰ may not be a single bond and when A²⁰ represents a singlebond, then G and the nitrogen atom bonded to R¹⁰ and R²⁰ must be bondedwith more than two carbon atoms in between. In addition, when A²⁰represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A²⁰and the nitrogen atom bonded to R¹⁰ and R²⁰ must be bonded with morethan two carbon atoms in between.

R¹⁰ and R²⁰ are either identical or different, and either represent onefunctional group chosen from the following items 1) to 7), i.e.,

-   1) a hydrogen atom (however, when R¹⁰ and R²⁰ both represent a    hydrogen atom, only in the case where G is equal to Formula (G1)),-   2) when G is not equal to Formula (G7), a substituted or an    unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine    atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,    alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to    10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having    2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms,    amino group having 0 to 14 carbon atoms, acylamino group having 1 to    10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms,    imino group having 1 to 10 carbon atoms, cyano group, nitro group,    sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to    6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms,    cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and,    heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms,    or sulfur atoms) may be cited as substituents),-   3) when G is not equal to Formula (G7), a substituted or an    unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   4) when G is not equal to Formula (G7), a substituted or an    unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group (containing    1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   6) when G is not equal to Formula (G7), an acyl group having 1 to 10    carbon atoms-   7) when G is not equal to Formula (G7), a sulfonyl group having 1 to    8 carbon atoms (however, when either R¹⁰ or R²⁰ represents a    sulfonyl group having 1 to 8 carbon atoms, the other may neither be    an acyl group having 1 to 10 carbon atoms nor a sulfonyl group    having 1 to 8 carbon atoms),-   or, when R¹⁰ and R²⁰ are bonded together, they represent a    functional group forming a cyclic amino group having 4 to 8 carbon    atoms together with the nitrogen atom they are bonded to (for said    cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1    to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents)]

PREFERRED EMBODIMENTS

In the following, the present invention will be explained in detail.

In Formula (1) above, the symbol

represents a single bond or a double bond. G1, G2, G5, G6, G8, G10, G11and G12 may be cited as acceptable G for forming a double bond with sucha bonding site.

In other words, Formula (1) above, in combination with G, forms one ofthe Formulae (1-G1), (1-G2), (1-G3), (1-G4), (1-G5), (1-G6), (1-G7),(1-G8), (1-G9), (1-G10), (1-G11) or (1-G12), below.

[In Formula (1-G1), Formula (1-G2), Formula (1-G3), Formula (1-G4),Formula (1-G5), Formula (1-G6), Formula (1-G7), Formula (1-G8), Formula(1-G9), Formula (1-G10), Formula (1-G11) and Formula (1-G12), the symbol

, A¹, A², A³, A⁴, R¹, R², R⁴, R⁵, R⁶, R⁷, m and W, have the samedefinitions as above.]

G1, G2, G3, G4, G5, G6 and G7 may be cited as such a preferredfunctional group for G. Among them G1, G3 and G7 are more preferred andG1 is especially preferred.

Each of the above Formulae (1-G1), (1-G2), (1-G3), (1-G4), (1-G5),(1-G6), (1-G7), (1-G8), (1-G9), (1-G10), (1-G11) and (1-G12) have apreferred spatial configuration and the ones represented by the Formulae(1-G1E), (1-G2E), (1-G3E), (1-G4E), (1-G5E), (1-G6E), (1-G7E), (1-G8E),(1-G9E), (1-G10E), (1-G11E) and (1-G12E) below may be cited.

[In Formula (1-G1E), Formula (1-G2E), Formula (1-G3E), Formula (1-G4E),Formula (1-G5E), Formula (1-G6E), Formula (1-G7E), Formula (1-G8E),Formula (1-G9E), Formula (1-G10E), Formula (1-G11E) and Formula(1-G12E), the symbol

, A¹, A², A³, A⁴, R¹, R², R⁴, R⁵, R⁶, R⁷, m, and W have the samedefinitions as above. The symbol

indicates that the bond is in the βposition with respect to the carbonatom forming the cyclic structure it is bonded to. The symbol

indicates that the bonds are in the a position with respect to thecarbon atoms forming the cyclic structure they are bonded to.]

In the above Formula (1), R⁴ represents a hydrogen atom, an acyl grouphaving 2 to 10 carbon atoms, a tri(hydrocarbon group having 1 to 7carbon atoms) silyl group or a functional group forming the acetal bondtogether with the oxygen atom bonded to R⁴.

As examples of such R⁴ which are acyl groups having 2 to 10 carbonatoms, an acetyl group, a trifluoroacetyl group, a propionyl group, abutyryl group, an isobutyryl group, a valeryl group, an hexanoyl group,a benzoyl group, a phenylacetyl group, a phenylpropionyl group, and acinnamoyl group may be cited. However, an acetyl group and a benzoylgroup may be cited as preferred examples.

In addition, as examples of a tri(hydrocarbon group having 1 to 7 carbonatoms) silyl group, a trimethylsilyl group, a triethylsilyl group, adimethylisopropylsilyl group, a dimethylhexylsilyl group, at-butyldimethylsilyl group, a triisopropylsilyl group, at-butyldiphenylsilyl group, and a tribenzylsilyl group may be cited.However, a trimethylsilyl group, a triethylsilyl group, and at-butyldimethylsilyl group may be cited as preferred examples.

In addition, as examples of functional groups forming the acetal bondtogether with the oxygen atom bonded to R⁴, a methoxymethyl group, a1-ethoxyethyl group, a 1-methoxy-1-methylethyl group, a2-ethoxy-1-methylethyl group, a 2-methoxyethoxymethyl group, atetrahydropyrane-2-yl group and a6,6-dimethyl-3-oxa-2-oxo-bicyclo[3.1.0]hexane-4-yl group may be cited.However, a methoxymethyl group, a 2-methoxyethoxymethyl group, and atetrahydropyran-2-yl group may be cited as preferred examples.

As particularly preferred examples of such R⁴, a hydrogen atom; anacetyl group, a t-butyldimethylsilyl group and a tetrahydropyran-2-ylgroup may be cited.

In the above formula (1), W represents one of: a single bond, —CH₂—,—(CH₂)₂—, —(CH₂)₃—, —CH═CH—, —CH═CHCH₂—, —C≡C— or —C≡CCH₂—. For said W,—CH═CH— or —CH═CHCH₂— may be cited as preferred examples.

R⁵ and R⁶ are either identical or different and, either represents onefunctional group chosen from the following items 1) to 5), i.e.,

-   1) a hydrogen atom,-   2) a substituted or an unsubstituted aliphatic hydrocarbon group    having 1 to 10 carbon atoms fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents, substituted or unsubstituted alicyclic hydrocarbon    group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having    1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents), substituted or    unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms    (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine    atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having    1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms,    aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to    10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, cyano group, nitro group, sulfide group having 1 to 6    carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents), and, substituted or unsubstituted heterocyclic group    having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the    cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom,    chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy    group having 1 to 4 carbon atoms, aryloxy group having 6 to 10    carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents) may be cited as substituents),-   3) a substituted or an unsubstituted alicyclic hydrocarbon group    having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon    atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon    atoms, carbamoyl group having 1 to 15 carbon atoms, amino group    having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon    atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group    having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group    having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon    atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited    as substituents),-   4) a substituted or an unsubstituted aromatic hydrocarbon group    having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group having 1 to    4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   or, when R⁵ and R⁶ are bonded to each other, they represent a    substituted or an unsubstituted alicyclic hydrocarbon chain having 4    to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine    atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,    alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to    10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents).

R⁷ represents a hydrogen atom, an acyl group having 2 to 10 carbonatoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group,an alkoxycarbonyl group having 2 to 5 carbon atoms, a sulfonyl grouphaving 1 to 8 carbon atoms, a functional group forming the acetal bondtogether with the oxygen atom bound to R⁷, or, when R⁷ and R⁵ are bondedto each other, R⁷ represents one portion of the bond forming thecarbonyl group together with the carbon atom bonded to R⁵ and the oxygenatom bonded to R⁷.

In the partial structure represented by the Formula (W1) below, of theabove Formula (1),

m may be either 0 or 1. However, when W is a single bond, m is equalto 1. When m equals 1, the above Formula (1) represents Formula (W1A)below,

[In the formula, the symbol

indicates that R⁵¹ is in the β position with respect to the carbon atomit is bonded to. The symbol

indicates that the oxygen atom is in the α position with respect to thecarbon atom it is bonded to.

R⁵¹ and R⁶¹ are either identical or different and, either represents onefunctional group chosen from the following items 1) to 5), i.e.,

-   1) a hydrogen atom,-   2) a substituted or an unsubstituted aliphatic hydrocarbon group    having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents, substituted or unsubstituted alicyclic hydrocarbon    group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having    1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents), substituted or    unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms    (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine    atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having    1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms,    aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to    10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, cyano group, nitro group, sulfide group having 1 to 6    carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents), and, substituted or unsubstituted heterocyclic group    having 1 to 4 oxygen atoms, nitrogen atoms or sulfur atoms in the    cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom,    chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy    group having 1 to 4 carbon atoms, aryloxy group having 6 to 10    carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents) may be cited as substituents),-   3) a substituted or an unsubstituted alicyclic hydrocarbon group    having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon    atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon    atoms, carbamoyl group having 1 to 15 carbon atoms, amino group    having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon    atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group    having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group    having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon    atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited    as substituents),-   4) a substituted or an unsubstituted aromatic hydrocarbon group    having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group having 1 to    4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   or, when R⁵¹ and R⁶¹ are bonded to each other, they represent a    substituted or an unsubstituted alicyclic hydrocarbon chain having 4    to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine    atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,    alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to    10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents).

R⁷¹ represents a hydrogen atom, an acyl group having 2 to 10 carbonatoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group,an alkoxycarbonyl group having 2 to 5 carbon atoms, a sulfonyl grouphaving 1 to 8 carbon atoms, and a functional group forming the acetalbond together with the oxygen atom bound to R⁷¹.]

Formula (W1B) below,

[In the formula, R⁵¹, R⁶¹ and R⁷¹ have the same definitions as above.The symbol

indicates that the oxygen is in the β position with respect to thecarbon atom it is bonded to. The symbol

indicates that R⁵¹ is in the α position with respect to the carbon atomit is bonded to.] or Formula (W1C) below,

[In the formula, R⁶² represents a functional group chosen from thefollowing items 1] to 5], i.e.,

-   1) a hydrogen atom,-   2) a substituted or an unsubstituted aliphatic hydrocarbon group    having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents, substituted or unsubstituted alicyclic hydrocarbon    group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having    1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents), substituted or    unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms    (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine    atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having    1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms,    aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to    10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, cyano group, nitro group, sulfide group having 1 to 6    carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents), and, substituted or unsubstituted heterocyclic group    having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the    cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom,    chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy    group having 1 to 4 carbon atoms, aryloxy group having 6 to 10    carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents) may be cited as substituents),-   3) a substituted or an unsubstituted alicyclic hydrocarbon group    having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon    atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon    atoms, carbamoyl group having 1 to 15 carbon atoms, amino group    having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon    atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group    having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group    having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon    atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited    as substituents),-   4) a substituted or an unsubstituted aromatic hydrocarbon group    having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group having 1 to    4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents)].

If m equals to 0 the above Formula (W1) represents the Formula (W1D)below

[In the formula, R⁶² has the same definition as above.]

When the above Formula (W1) represents the above Formula (W1A) or (W1B),these may be combined in any proportion.

In the above formulae(W1A), (W1B), (W1C) or (W1D), R⁵¹, R⁶¹ and R⁶²represent one of the items 1) to 5):

-   1) a hydrogen atom,-   2) a substituted or an unsubstituted aliphatic hydrocarbon group    having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents, substituted or unsubstituted alicyclic hydrocarbon    group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having    1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents), substituted or    unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms    (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine    atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having    1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms,    aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to    10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, cyano group, nitro group, sulfide group having 1 to 6    carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents), and, substituted or unsubstituted heterocyclic group    having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the    cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom,    chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy    group having 1 to 4 carbon atoms, aryloxy group having 6 to 10    carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents) may be cited as substituents),-   3) a substituted or an unsubstituted alicyclic hydrocarbon group    having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon    atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon    atoms, carbamoyl group having 1 to 15 carbon atoms, amino group    having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon    atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group    having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group    having 0.1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon    atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited    as substituents),-   4) a substituted or an unsubstituted aromatic hydrocarbon group    having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group having 1 to    4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents).

As examples of such R⁵¹, R⁶¹ or R⁶² which are unsubstituted aliphatichydrocarbon groups having 1 to 10 carbon atoms, alkyl groups such as amethyl group, an ethyl group, a propyl group, an isopropyl group, abutyl group, an isobutyl group, an s-butyl group, a t-butyl group, apentyl group, an isopentyl group, a neopentyl group, a 4-methylpentylgroup, a hexyl group, a heptyl group, a 2-methylhexyl group, a1,1-dimethylpentyl group, an octyl group, a 3,7-dimethyloctyl group, anonyl group, and a decyl group, alkenyl groups such as a vinyl group, a1-methylvinyl group, a 1-ethylvinyl group, a 1-propenyl group, a2-propenyl group, a 2-methyl-1-propenyl group, a 1-butenyl group, a2-butenyl group, a 2-methyl-1-butenyl group, a 1,3-butadienyl group, a1-pentenyl group, a 2-pentenyl group, a 4-methyl-1-pentenyl group, a1-hexenyl group, a 2-hexenyl group, a 3-hexenyl group, a 4-hexenylgroup, a 5-hexenyl group, a 1,5-hexadienyl group, a 2-heptenyl group, a2-octenyl group, a 2-nonenyl group, and a 2-decenyl group, and alkynylgroups such as an ethynyl group, a 1-propynyl group, a 2-propynyl group,a 1-butynyl group, a 2-methyl-1-butynyl group, a 3,3-dimethyl-1-butynylgroup, a 1-pentynyl group, a 2-pentynyl group, a 3-pentynyl group, a1-hexynyl group, a 2-hexynyl group, a 3-hexynyl group, a 4-hexynylgroup, a 1-methyl-3-pentynyl group, a 1-methyl-3-hexynyl group, a2-heptynyl group, a 2-octynyl group, a 2-nonynyl group and a 2-decynylgroup may be cited. As preferred examples, a methyl group, an ethylgroup, a propyl group, a butyl group, a pentyl group, a hexyl group, aheptyl group, a 2-methylhexyl group, a 1,1-dimethylpentyl group, a1-propenyl group, a 1-butenyl group, a 2-pentenyl group, a 1-octenylgroup and a 1-methyl-3-pentynyl group may be cited.

As examples of such R⁵¹, R⁶¹ or R⁶² which are unsubstituted alicyclichydrocarbon groups having 3 to 8 carbon atoms, a cyclopropyl group, acyclobutyl group, a cyclopentyl group, a 1-cyclopentenyl group, acyclohexyl group, a 1-cyclohexenyl group, a 3-cyclohexenyl group, a4-cyclohexenyl group, a cycloheptyl group, a 1-cycloheptenyl group, anda cyclooctyl group may be cited. As preferred examples, the cyclopentylgroup and the cyclohexyl group may be cited.

As examples of such R⁵¹, R⁶¹ or R⁶² which are unsubstituted aromatichydrocarbon groups having 6 to 10 carbon atoms, a phenyl group, a1-naphthyl group and a 2-naphthyl group may be cited. As a preferredexample, a phenyl group may be cited.

As examples of such R⁵¹, R⁶¹ or R⁶² which are unsubstituted heterocyclicgroups having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms inthe cycle, monocyclic or bicyclic groups such as a furyl group, athiophenyl group, a pyrrolyl group, an oxazolyl group, an isooxazolylgroup, a thiazolyl group, an isothiazolyl group, an imidazolyl group, apyrazolyl group, a triazolyl group, a tetrazolyl group, a pyranyl group,a pyridyl group, a pyrazinyl group, a pyrimidinyl group, a pyridazinylgroup, a benzofuranyl group, an indolyl group, a benzimidazolyl group, abenzothiazolyl group, a benzoxazolyl group, a quinolyl group, anisoquinolyl group, a quinazolyl group, a purinyl group, a pteridinylgroup, an azetidinyl group, a pyrrolidinyl group, a morpholino group, apiperidino group and a piperazinyl group may be cited. As a preferredexample, a pyridyl group may be cited.

As examples of substitution groups when R⁵¹, R⁶¹ or R⁶² is a substitutedaliphatic hydrocarbon group having 1 to 10 carbon atoms, a fluorineatom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group,alkoxy groups having 1 to 4 carbon atoms which are a methoxy group, anethoxy group, a propoxy group, an isopropoxy group, a butoxy group, ans-butoxy group and a t-butoxy group, aryloxy groups having 6 to 10carbon atoms which are a phenoxy group, a 1-naphthoxy group and a2-naphthoxy group, aralkoxy groups having 7 to 9 carbon atoms such as abenzyloxy group, an α-phenethyloxy group, a β-phenethyloxy group, aphenylpropyloxy group and a cinnamyloxy group, acyloxy groups having 2to 10 carbon atoms such as an acetoxy group, a trifluoroacetoxy group, apropionyloxy group, an isopropionyloxy group, a butyryloxy group, anisobutyryloxy group, an s-butyryloxy group, a valeryloxy group, anisovaleryloxy group, a hexanoyloxy group, a heptanoyloxy group, anoctanoyloxy group, a nonanoyloxy group, a decanoyloxy group, abenzoyloxy group, a phenylacetyloxy group, a cinnamoyloxy group, acyclopentylcarboxy group, a cyclohexylcarboxy group and acycloheptylcarboxy group, sulfonyloxy groups having 1 to 8 carbon atomssuch as a methanesulfonyloxy group, a trifluoromethanesulfonyloxy group,an ethanesulfonyloxy group, a butanesulfonyloxy group, at-butanesulfonyloxy group, a nonafluorobutanesulfonyloxy group, abenzenesulfonyloxy group, a p-bromobenzenesulfonyloxy group, ap-toluenesulfonyloxy group, a benzylsulfonyloxy group, anα-phenethylsulfonyloxy group and a β-phenethylsulfonyloxy group, an oxogroup, a carboxyl group, alkoxycarbonyl groups having 2 to 10 carbonatoms such as a methoxycarbonyl group, an ethoxycarbonyl group, apropoxycarbonyl group, an isopropoxycarbonyl group, a butoxycarbonylgroup, an isobutoxycarbonyl group, an s-butoxycarbonyl group, at-butoxycarbonyl group, a phenoxycarbonyl group, a 1-naphthoxycarbonylgroup, a 2-naphthoxycarbonyl group, a benzyloxycarbonyl group, anα-phenethyloxycarbonyl group, a β-phenethyloxycarbonyl group, carbamoylgroups having 1 to 15 carbon atoms such as a carbamoyl group, anN-methylcarbamoyl group, an N-ethylcarbamoyl group, an N-propylcarbamoylgroup, an N-isopropylcarbamoyl group, an N-butylcarbamoyl group, anN-isobutylcarbamoyl group, an N–s-butylcarbamoyl group, anN-t-butylcarbamoyl group, an N-pentylcarbamoyl group, anN-hexylcarbamoyl group, an N-phenylcarbamoyl group, an N-benzylcarbamoylgroup, an N-phenethylcarbamoyl group, an N-cyclopropylcarbamoyl group,an N-cyclobutylcarbamoyl group, an N-cyclopentylcarbamoyl group, anN-cyclohexylcarbamoyl group, an N-cycloheptylcarbamoyl group, anN-cyclopropanemethylcarbamoyl group, an N,N-dimethylcarbamoyl group, anN,N-ethylmethylcarbamoyl group, an N,N-diethylcarbamoyl group, anN,N-dipropylcarbamoyl group, an N,N-dibutylcarbamoyl group, anN,N-dicyclohexylcarbamoyl group, an N,N-diphenylcarbamoyl group, and anN,N-dibenzylcarbamoyl group, amino groups having 0 to 14 carbon atomssuch as an amino group, a methylamino group, an ethylamino group, apropylamino group, an isopropylamino group, a butylamino group, anisobutylamino group, an s-butylamino group, a t-butylamino group, apentylamino group, an hexylamino group, an heptylamino group, anoctylamino group, a nonylamino group, a decylamino group, a phenylaminogroup, a benzylamino group, a phenethylamino group, a cyclopropylaminogroup, a cyclobutylamino group, a cyclopentylamino group, acyclohexylamino group, a cycloheptylamino group, a cyclooctylaminogroup, a cyclopropanemethylamino group, a dimethylamino group, anN-methylamino group, a diethylamino group, an N-methylpropylamino group,an N-methylisopropylamino group, an N-methylbutylamino group, anN-methyl-t-butylamino group, an N-ethylisopropylamino group, adipropylamino group, a diisopropylamino group, an ethylbutylamino group,an N-methylhexylamino group, a dibutylamino group, a dipentylaminogroup, a dicyclohexylamino group, a diphenylamino group, a dibenzylaminogroup a piperidino group and a morpholino group, acylamino groups having1 to 10 carbon atoms such as a formylamino group, an acetylamino group,a trifluoroacetylamino group, a propionylamino group, a butyrylaminogroup, an isobutyrylamino group, a valerylamino group, an hexanoylaminogroup, a benzoylamino group, a phenylacetylamino group, aphenylpropionylamino group, and a cinnamoylamino group, sulfonylaminogroups having 1 to 8 carbon atoms such as a methanesulfonylamino group,a trifluoromethanesulfonylamino group, an ethanesulfonylamino group, abutanesulfonylamino group, a t-butanesulfonylamino group, anonafluorobutanesulfonylamino group, a benzenesulfonylamino group, ap-bromobenzenesulfonylamino group, a p-toluenesulfonylamino group, abenzylsulfonylamino group, an α-phenethylsulfonylamino group and aβ-phenethylsulfonylamino group, imino groups having 1 to 10 carbon atomssuch as a methylimino group, an ethylimino group, a propylimino group,an isopropylimino group, a butylimino group, an isobutylimino group, apentylimino group, an hexylimino group, an heptylimino group, anoctylimino group, a nonylimino group, a decylimino group, a phenyliminogroup, a benzylimino group, a phenethylimino group, a cyclopropyliminogroup, a cyclobutylimino group, a cyclopentylimino group, acyclohexylimino group, and a cycloheptylimino group, a cyano group, anitro group, sulfide groups having 1 to 6 carbon atoms such as amethylthio group, an ethylthio group, a propylthio group, anisopropylthio group, a butylthio group, an isobutylthio group, ans-butylthio group, a t-butylthio group, a pentylthio group, an hexylthiogroup, a phenylthio group, a cyclopentylthio group and a cyclohexylthiogroup, sulfinyl groups having 1 to 6 carbon atoms such as amethylsulfinyl group, an ethylsulfinyl group, a propylsulfinyl group, anisopropylsulfinyl group, a butylsulfinyl group, an isobutylsulfinylgroup, an s-butylsulfinyl group, a t-butylsulfinyl group, apentylsulfinyl group, a hexylsulfinyl group, a phenylsulfinyl group, acyclopentylsulfinyl group, and a cyclohexylsulfinyl group, sulfonylgroups having 1 to 6 carbon atoms such as a methylsulfonyl group, anethylsulfonyl group, a propylsulfonyl group, an isopropylsulfonyl group,a butylsulfonyl group, an isobutylsulfonyl group, an s-butylsulfonylgroup, a t-butylsulfonyl group, a pentylsulfonyl group, a hexylsulfonylgroup, a phenylsulfonyl group, a cyclopentylsulfonyl group and acyclohexylsulfonyl group, a substituted or unsubstituted alicyclichydrocarbon group having 3 to 8 carbon atoms (in addition to the sameexamples as the examples chosen among the examples indicated as examplesof substitution group in the case of the previously-mentioned aliphatichydrocarbon group having 1 to 10 carbon atoms, aliphatic hydrocarbongroups having 1 to 6 carbon atoms which are a methyl group, an ethylgroup, a propyl group, an isopropyl group, a butyl group, an isobutylgroup, an s-butyl group, an t-butyl group, a pentyl group, a hexylgroup, a 2-propenyl group, a 1-butenyl group, a 2-butenyl group, a2-pentenyl group, a 3-pentenyl group, a 2-hexenyl group, a 3-hexenylgroup, a 4-hexenyl group, a 2-butynyl group, a 2-pentynyl group, a3-pentynyl group, a 2-hexynyl group and a 3-hexynyl group, acyl groupshaving 1 to 10 carbon atoms such as a formyl group, an acetyl group, atrifluoroacetyl group, a propionyl group, a butyryl group, an isobutyrylgroup, a valeryl group, an hexanoyl group, a benzoyl group, aphenylacetyl group, a phenylpropionyl group and a cinnamoyl group may becited as examples of substitution groups for such an alicyclichydrocarbon group having 3 to 8 carbon atoms), a substituted orunsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms (inaddition to the same examples as the examples chosen among the examplesindicated as examples of substitution groups in the case of thepreviously-mentioned aliphatic hydrocarbon group having 1 to 10 carbonatoms, and in the case of the previously-mentioned alicyclic hydrocarbongroup having 3 to 8 carbon atoms, alkyl groups having 1 to 4 carbonatoms which are a methyl group, an ethyl group, a propyl group, anisopropyl group, a butyl group, an isobutyl group, an s-butyl group anda t-butyl group may be cited as substitution examples for such aromatichydrocarbon groups having 6 to 10 carbon atoms), a substituted orunsubstituted heterocyclic group having 1 to 4 oxygen atoms, nitrogenatoms, or sulfur atoms in the cycle (the same examples as the exampleschosen among the examples indicated as examples of substitution groupsin the case of the previously-mentioned aliphatic hydrocarbon grouphaving 1 to 10 carbon atoms, and in the case of the previously-mentionedalicyclic hydrocarbon group having 3 to 8 carbon atoms may be cited assubstitution examples of such a heteocyclic group) may be cited. Aspreferred examples of such substitution groups for aliphatic hydrocarbongroups having 1 to 10 carbon atoms, a fluorine atom, a hydroxyl group, aphenyl group, a tolyl group, a 4-methoxyphenyl group, a4-dimethylaminophenyl group, a phenoxy group, a 3,5-dichlorophenoxygroup, a cyclopentyl group, a cyclohexyl group, a 3-ethylcyclopentylgroup and a phenylsulfonyl group may be cited.

As examples of substitution groups when R⁵¹, R⁶¹ or R⁶² are substitutedalicyclic hydrocarbon groups having 3 to 8 carbon atoms, the sameexample as the examples chosen among the examples given for theabove-mentioned substituted aliphatic hydrocarbon group having 1 to 10carbon atoms may be cited. As preferred examples of substitution groupsfor such alicyclic hydrocarbon groups having 3 to 8 carbon atoms, amethyl group, an ethyl group, a propyl group, a hydroxyl group, amethoxy group and an ethoxy group may be cited.

As examples of substitution groups when R⁵¹, R⁶¹ or R⁶² are substitutedaromatic hydrocarbon groups having 6 to 10 carbon atoms, the sameexample as the examples chosen among the examples given for theabove-mentioned substituted aliphatic hydrocarbon group having 1 to 10carbon atoms may be cited. As preferred examples of substitution groupsfor aromatic hydrocarbon groups having 6 to 10 carbon atoms, a methylgroup, an ethyl group, a propyl group, a hydroxyl group, a methoxygroup, an ethoxy group, a fluorine atom, a chlorine atom, a bromine atomand an iodine atom may be cited.

As examples of substitution groups when R⁵¹, R⁶¹ or R⁶² are substitutedheterocyclic groups having 1 to 4 oxygen atoms, nitrogen atoms, orsulfur atoms in the cycle, the same examples as the examples chosenamong the examples given for the above-mentioned substituted aliphatichydrocarbon group having 1 to 10 carbon atoms may be cited. As preferredexamples of substitution groups for such heterocyclic groups having 1 to4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle, a methylgroup, an ethyl group, a propyl group, a hydroxyl group, a methoxy groupand an ethoxy group may be cited.

In addition, in the above Formula (W1A) or Formula (W1B), R⁵¹ and R⁶¹are bonded to each other, and represent a substituted or anunsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atoms(alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy grouphaving 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms,sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl grouphaving 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, aminogroup having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbonatoms, sulfonylamino group having 1 to 8 carbon atoms, cyano group,nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl grouphaving 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbonatoms may be cited as substituents).

As examples of such unsubstituted alicyclic hydrocarbon chains having 4to 7 carbon atoms, tetramethylene group, pentamethylene group,hexamethylene group and heptamethylene group may be cited. As preferredexamples the tetramethylene group and the pentamethylene group may becited.

As examples of substitution groups wherein R⁵¹ and R⁶¹ are bonded toeach other and form a substituted alicyclic hydrocarbon chain having 4to 7 carbon atoms, the same examples as the examples chosen among theexamples given for the above-mentioned substituted aliphatic hydrocarbongroup having 1 to 10 carbon atoms may be cited. As preferred examples ofsubstitution groups for such groups forming an alicyclic hydrocarbonchain having 4 to 7 carbon atoms, a methyl group, an ethyl group, apropyl group, a hydroxyl group, a methoxy group and an ethoxy may becited.

In the above Formula (W1A) or Formula (W1B), R⁷¹ represents a hydrogenatom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon grouphaving 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having2 to 5 carbon atoms, a sulfonyl group having 1 to 8 carbon atoms, afunctional group forming the acetal bond together with the oxygen atombound to R⁷¹.

As examples of such acyl groups having 2 to 10 carbon atoms, an acetylgroup, a trifluoroacetyl group, a propionyl group, a butyryl group, anisobutyryl group, a valeryl group, an hexanoyl group, a benzoyl group, aphenylacetyl group, a phenylpropionyl group and a cinnamoly group may becited. As preferred examples an acetyl group and a benzoyl group may becited. As examples of tri(hydrocarbon group having 1 to 7 carbon atoms)silyl group, a trimethylsilyl group, a triethylsilyl group, adimethylisopropyls group, a dimethylhexylsilyl group, at-butyldimethylsilyl group, a triisopropylsilyl group, at-butyldiphenylsilyl group and a tribenzylsilyl group may be cited. Aspreferred examples, a trimethylsilyl group, a triethylsilyl group and at-butyldimethylsilyl group may be cited.

As examples of alkoxycarbonyl groups having 2 to 5 carbon atoms, amethoxycarbonyl group, an ethoxycarbonyl group, a propoxycarbonyl group,an isopropoxycarbonyl group, a butoxycarbonyl group, a s-butoxycarbonylgroup and a t-butoxycarbonyl group may be cited. As preferred examples,a methoxycarbonyl group and an ethoxycarbonyl group may be cited.

As examples of sulfonyl groups having 1 to 8 carbon atoms, amethanesulfonyl group, a trifluoromethanesulfonyl group, anethanesulfonyl group, a butanesulfonyl group, a t-butanesulfonyl group,a nonafluorobutanesulfonyl group, a benzenesulfonyl group, ap-bromobenzenesulfonyl group, a p-toluenesulfonyl group, abenzylsulfonyl group, an α-phenethylsulfonylamino group, and aβ-phenethylsulfonylamino group may be cited. As preferred examples amethanesulfonyl group and a trifluoromethanesulfonyl group may be cited.

As examples of functional groups forming the acetal bond together withthe oxygen atom bound to R⁷¹ a methoxymethyl group, a 1-ethoxyethylgroup, a 1-methoxy-1-methylethyl group, a 2-ethoxy-1-methylethyl group,a 2-methoxyethoxymethyl group, a tetrahydropyrane-2-yl group, a6,6-dimethyl-3-oxa-2-oxo-bicyclo[3.1.0]hexane-4-yl group may be cited.As preferred examples, a methoxymethyl group, a 2-methoxyethoxymethylgroup and a tetrahydropyran-2-yl group may be cited. As particularlypreferred such functional groups for R⁷¹, a hydrogen atom, an acetylgroup, a trimethylsilyl group, a t-butyldimethylsilyl group and atetrahydropyran-2-yl may be cited.

As such preferred examples of the above Formula (W1), the items 1) to 6)shown below may be cited.

-   1) a hydrogen atom,-   2) a hydroxymethy group, a formyl group, a methanesulfonyloxymehyl    group, a methoxycarbonyloxymethyl group, a methyl group, an ethyl    group, a propyl group, a butyl group, a pentyl group, a hexyl group,    a heptyl group, an octyl group, a cyclopentyl group, a cyclohexyl    group, a cycloheptyl group, a phenyl group, an o-tolyl group, an    m-tolyl group, a p-tolyl group, a 4-methoxyphenyl group, an    4-N,N-dimethylaminophenyl group, a 3-chlorophenyl group, a    4-chlorophenyl group, a 4-fluorophenyl group, a 4-bromophenyl group,    3,5-dichlorophenyl group, a benzyl group, an α-phenethyl group, a    β-phenethyl group, an o-tolylmethyl group, an m-tolylmethyl group, a    p-tolylmethyl group, a 3-ethylphenyl group, a 4-ethylphenyl group, a    3-propylphenyl group, a 2-(o-tolyl)ethyl group, a 2-(m-tolyl)ethyl    group, a 2-(p-tolyl)ethyl group, a 3-(o-tolyl)propyl group, a    3-(m-tolyl)propyl group, a 3-(p-tolyl)propyl group, a    1,1-bis(phenylsulfonyl)-2-(o-tolyl)ethyl group, a    1,1-bis(phenylsulfonyl)-2-(m-tolyl)ethyl group, a    1,1-bis(phenylsulfonyl)-2-(p-tolyl)ethyl group, a    1,1-bis(phenylsulfonyl)-2-(o-tolyl)propyl group, a    1,1-bis(phenylsulfonyl)-2-(m-tolyl)propyl group, a    1,1-bis(phenylsulfonyl)-2-(p-tolyl)propyl group,-   3) a 1-hydroxypentyl group, a 1-hydroxyhexyl group, a    1-hydroxyheptyl group, a 1-hydroxyoctyl group, a    1-hydroxy-1-methylpentyl group, a 1-hydroxy-1-ethylpentyl group, a    1-hydroxy-1-vinylpentyl group, a 1-hydroxy-1-methylhexyl group, a    1-hydroxy-1-ethylhexyl group, a 1-hydroxy-3-methylhexyl group,    1-hydroxy-2-butyl-2-propene group, a 1-hydroxy-2-methylhexyl group,    a 1-hydroxy-2-fluorohexyl group, a 1-hydroxy-2,2-dimethylhexyl    group, a 1 hydroxy-3-ethoxy-2,2-dimethylpropane group, a    1-hydroxy-2,2-difluorohexyl group, a 1-hydroxy-2,2,6-trimethylheptyl    group, a 1-hydroxy-2-fluoro-1-methyloctyl group, a    1-hydroxyhexa-3-enyl group, a 1-hydroxy-5-methylhexa-4-enyl group, a    1-hydroxy-2,5-dimethylhexa-4-enyl group, a    1-hydroxy-3,7-dimethylhexa-4-enyl group, a    1-hydroxy-2,2,5-trimethylhexa-4-enyl group,    1-hydroxy-2,2-dimethylpenta-3-ynyl group, a    1-hydroxy-2,2-dimethylpenta-3-ynyl group, a 1-hydroxyhexa-4-ynyl    group, a 1-hydroxy-2-methylhexa-4-ynyl group, a    1-hydroxy-2,2-dimethylhexa-4-ynyl group, a    1-hydroxy-2-methylhepta-4-ynyl group, a    1-hydroxy-4-cyclopropyl-2-methylbutyl group, a    1-hydroxy-2-cyclopentylethyl group, a 1-hydroxy-2-cyclohexylethyl    group, a 1-hydroxy-2-phenylethyl group, a 1-hydroxy-2-phenylpropy    group, a 1-hydroxy-1-(o-tolyl)methyl group, a    1-hydroxy-1-(m-tolyl)methyl group, a 1-hydroxy-1-(p-tolyl)methyl    group, a 1-hydroxy-1-(3-ethylphenyl)methyl group, a    1-hydroxy-1-(4-ethylphenyl)methyl group, a    1-hydroxy-1-(3-propylphenyl)methyl group, a    1-hydroxy-2(o-tolyl)ethyl group, a 1-hydroxy-2-(m-tolyl)ethyl group,    a 1-hydroxy-2-(p-tolyl)ethyl group, a 1-hydroxy-3-(o-tolyl)propyl    group, a 1-hydroxy-3-(m-tolyl)propyl group, a    1-hydroxy-3-(p-tolyl)propyl group, a 1-hydroxy-4-(o-tolyl)butyl    group, a 1-hydroxy-4-(m-tolyl)butyl group, a    1-hydroxy-4-(p-tolyl)butyl group, a    1-hydroxy-2-(3-chlorophenyl)ethyl group, a 1-hydroxy-2-phenoxyethyl    group, a 1-hydroxy-2-(4-fluorophenoxy)ethyl group, a    1-hydroxy-2-(3-chloropheoxyl)ethyl group, a    1-hydroxy-1-cyclopentylmethyl group, a 1-hydroxy-1-cyclohexylmethyl    group, a 1-hydroxy-1-cyclopentylethyl group, a    1-hydroxy-[(4-cyclohexenyl)methyl group, a    1-hydroxy-1-(3-ethylcyclopentyl)methyl group, a    1-hydroxy-1-(2-methylcyclopentyl)methyl group, a    1-hydroxy-1-(2-methylcyclohexyl)methyl group, a    1-hydroxy-1-(3-methylcyclohexyl)methyl group, a    1-hydroxy-1-(4-methylcyclohexyl)methyl group, a    1-hydroxy-1-(2,2,4-trimethylcyclohexyl)methyl group, a    1-hydroxy-1-(1-(2-butynyl) cyclobutyl)methyl group, a    1-hydroxy-1-(1-(2-pentynyl)cyclobutyl)methyl group, a    1-hydroxy-1-phenylmethyl group, a 1-hydroxy-1-(4-chlorophenyl)methyl    group, a 1-hydroxy-1-(4-bromophenyl)methyl group, a    1-hydroxy-1-(3-chlorophenyl)methyl group, a    1-hydroxy-1-(4-methoxyphenyl)methyl group, a    1-hydroxy-1-(4-N,N-dimetylaminophenyl)methyl group, a    1-hydroxy-1-(1-naphthyl)methyl group, a    1-hydroxy-1-(2-naphthyl)methyl group,-   4) a functional group described in 3) above, wherein the hydroxy    group has been substituted for an acetyloxy group, a benzoyloxy    group, a trimethylsilyloxy group, a t-butyldimethylsilyloxy group, a    tetrahydropyrane-2-yloxy group or a methanesulfonyloxy group,-   5) a pentanoyl group, a hexanoyl group, a heptanoyl group, an    octanoyl group, a 3-methylhexanoyl group, a 2-methylhexanoyl group,    a 2,2-dimethylhexanoyl group, a 2,2,6-trimethylheptanoyl group, a    3-hexenoyl group, a 5-methyl-4-hexenoyl group, a    2,5-dimethyl-4-hexenoyl group, a 3,7-dimethyl-6-octenoyl group, a    2,2,5-trimethyl-4-hexenoyl group, a 3-pentynoyl group, a    2,2-dimethyl-3-pentynoyl group, a 4-hexynoyl group, a    2-methyl-4-hexynoyl group, a 2,2-dimethyl-4-hexynoyl group, a    2-methyl-4-heptynoyl group, a 4-cyclopropyl-2-methylbutanoyl group,    a cyclopentylacetyl group, a cyclohexylacetyl group, a    2-phenylacetyl group, a 3-phenylpropanoyl group, a 2-methylbenzoyl    group, a 3-methylbenzoyl group, a 4-methylbenzoyl group, a    3-ethylbenzoyl group, a 4-ethylbenzoyl group, a 3-propylbenzoyl    group, an (o-tolyl)acetyl group, an (m-tolyl)acetyl group, a    (p-tolyl)acetyl group, 3-(o-tolyl)propanoyl group, a    3-(m-tolyl)propanoyl group, a 3-(p-tolyl)propanoyl group, a    4-(o-tolyl)butanoyl group, a 4-(m-tolyl)butanoyl group, a    4-(p-tolyl)butanoyl group, a (3-chlorophenyl)acetyl group, a    cyclopentylcarbonyl group, a cyclohexylcarbonyl group, a    3-ethylcyclopentylcarbonyl group, a 2-methylcyclopentylcarbonyl    group, a 2-methylcyclohexylcarbonyl group, a    3-methylcyclohexylcarbonyl group, a 4-methylcyclohexylcarbonyl    group, a benzoyl group, a 4-chlorobenzoyl group, a 4-bromobenzoyl    group, a 3-chlorobenzoyl group, a 4-methoxybenzoyl group, a    4-N,N-dimethylaminobenzoyl group, a 1-naphthylcarbonyl group, a    2-naphthylcarbonyl group,-   6) a 1-pentenyl group, a 1-hexenyl group, a 1-heptenyl group, a    1-octenyl group, a 2-methylhexene-1-yl group, a 2-ethylhexene-1-yl    group, a 2-methylheptene-1-yl group, a 2-ethylheptene-1-yl group, a    1-methylhexene-1-yl group, a 1-ethylhexene-1-yl group, a    3-methylhexene-1-yl group, a 1,3-hexadiene-1-yl group, a    5-methyl-1,4-hexadiene-1-yl group, a 2,5-dimethyl-1,4-hexadiene-1-yl    group, a 3,7-dimethyl-1,6-octadiene-1-yl group, a    penta-3-yn-1-en-1-yl group, a hexa-4-yn-1-en-1-yl group, a    2-methylhexa-4-yn-1-en-1-yl group, a 2-methylhepta-4-yn-1-en-1-yl    group, a 4-cyclopropyl-2-methyl-1-butene-1-yl group, a    2-cyclopentylvinyl group, a 2-cyclohexylvinyl group, a    2-phenylvinyl, a 3-phenyl-1-propene-1-yl group, a 2-(o-tolyl)vinyl    group, a 2-(m-tolyl)vinyl group, a 2-(p-tolyl)vinyl group, a    3-(o-tolyl)-1-propene-1-yl group, a 3-(m-tolyl)-1-propene-1-yl    group, a 3-(p-tolyl)-1-propene-1-yl group, a    4-(o-tolyl)-1-butene-1-yl group, a 4-(m-tolyl)-1-butene-1-yl group,    a 4-(p-tolyl)-1-butene-1-yl group, a 2-(3-ethylphenyl)vinyl group, a    2-(4-ethylphenyl)vinyl group, a 2-(3-propylphenyl)vinyl group, a    2-(3-chlorophenyl)vinyl group, a 2-(4-chlorophenyl)vinyl group, a    2-(4-methoxyphenyl)vinyl group, a 2-(4-N,N-dimethylaminophenyl)vinyl    group.

In the above Formula (1) A² represents a single bond, a Formula (A2A)shown below, a Formula (A2B) shown below or a Formula (A2C) shown below.

[In the formula, R³ represents a hydrogen atom, an alkyl group having 1to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms.]

[In the formula, n represents 0, 1, or 2.]

In the above Formula (A2B), R³ represents a hydrogen atom, an alkylgroup having 1 to 4 carbon atoms, or an acyl group having 1 to 10 carbonatoms.

As examples of R³ which are alkyl groups having 1 to 4 carbon atoms, amethyl group, an ethyl group, a propyl group, an isopropyl group, abutyl group, an isobutyl group, an s-butyl group and a t-butyl group maybe cited. As examples of R³ which are acyl groups having 1 to 10 carbonatoms, a formyl group, an acetyl group, a trifluoroacetyl group, apropionyl group, a butyryl group, an isobutyryl group, a valeryl group,an hexanoyl group, a benzoyl group, a phenylacetyl group, aphenylpropionyl group and a cinnamoly group may be cited. As preferredexamples of such an R³, a hydrogen atom, a methyl group, a formyl groupand an acetyl group may be cited.

In the above Formula (A2C), n represents 0, 1, or 2. However, 0 may becited as the preferred value for n.

A single bond, —O—, —NH—, —N(CH₃)— and —S— may be cited as suchpreferred functional groups for A².

In the above Formula (1), A¹ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges G and A² through an identical    atom or through different atoms, and chosen from a group consisting    of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an    alicyclic hydrocarbon group having 3 to 8 carbon atoms, a    heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or    sulfur atoms, and a phenylene group.

Examples of such A¹ which are aliphatic hydrocarbon groups having 1 to 3carbon atoms, are functional groups derived by removing hydrogen atomsfrom the same carbon atom or two different carbon atoms of a methane, anethene, a propane, an ethene, a propene, an acetylene or a propyne: whenG and A¹ are bonded through a single bond, A¹ is a bivalent functionalgroup derived by removing one hydrogen atom for each bond; when G and A¹are bonded through a double bond, A¹ is a trivalent functional groupderived by removing one hydrogen atom for one bond and two hydrogens forthe other bond. As preferred examples of such bivalent functionalgroups, —CH₂—, —(CH₂)₂—, —CH(CH₃)—, —(CH₂)₃—, —C(CH₃)₂—, —CH═CH—,—CH═CHCH₂—, —CH═C(CH₃)—, —C═C— and —C═CCH₂— may be cited, and aspreferred examples of such trivalent functional groups, ═CH—, =CHCH₂—,=C(CH₃)—, =CH(CH₂)₂—, =CHCH═CH— and ═CH—CH(CH₃)— may be cited.

As examples of A¹ which are alicyclic hydrocarbon groups having 3 to 8carbon atoms, are functional groups derived from a cyclopropane, acyclobutane, a cyclopentane, a cyclopentene, a cyclohexane, acyclohexene, a cycloheptane and a cyclooctane by removing hydrogen atomson the same carbon atom or two different carbon atoms: when G and A¹ arebonded through a single bond, A¹ is a bivalent functional group derivedby removing one hydrogen atom for each bond; when G and A¹ are bondedthrough a double bond, A¹ is a trivalent functional group derived byremoving one hydrogen atom for one bond and two hydrogens for the otherbond. As preferred examples of such bivalent functional groups, a1,2-cyclopropylene group, a cyclopropylydene group, a 1,2-cyclopentylenegroup, a 1,3-cyclopentylene group, a 1,2-cyclohexylene group, a1,3-cyclohexylene group, a 1,4-cyclohexylene may be cited, and as apreferred example of such a trivalent functional group, a1-cyclohexyl-4-ylidedene group may be cited.

As examples of A¹ which are heterocyclic groups having between 1 and 2oxygen atoms, nitrogen atoms, or sulfur atoms, bivalent functionalgroups derived by removing one hydrogen atom from each of two differentcarbon atoms such as a furan cycle, a thiofuran cycle, a pyrrole cycle,an oxazole cycle, an isooxazole cycle, a thiazole cycle, an isothioazolecycle, an imidazole cycle, a pyrazole cycle, a pyran group, a pyridinecycle, a pyrazine cycle, a pyrimidine cycle, a pyridazine cycle, anazetidine cycle, a pyrrolidine cycle, a piperidine cycle, a piperazinecycle and a morpholine cycle may be cited. As preferred functional groupfor such an A¹, the bond representing a single bond, —CH₂—, —(CH₂)₂—,═CH— and ═CHCH₂— may be cited.

In the above Formula (1), A³ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges A² and A⁴ through an identical    atom or through different atoms, and chosen from a group consisting    of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an    alicyclic hydrocarbon group having 3 to 8 carbon atoms, a    heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or    sulfur atoms, and a phenylene group.

As examples of such A³ which are aliphatic hydrocarbon groups having 1to 3 carbon atoms, alicyclic hydrocarbon groups having 3 to 8 carbonatoms, or heterocycles and which have heterocyclic groups having between1 and 2 oxygen atoms, nitrogen atoms, or sulfur atoms, among theexamples given in the above-mentioned A¹, the examples given as bivalentfunctional groups may be may be cited. As particularly preferredfunctional groups for such A³, the bond representing a single bond;—CH₂—, —(CH₂)₂—, —CH═CH— and a phenylene group may be cited.

In the above Formula (1), A⁴ represents either of the items 1) to 4)below

-   1) a single bond-   2) a carbonyl group-   3) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which    bridges the nitrogen atom, bonded to R¹ and R², and A³ through an    identical atom or through different atoms.-   4) when A⁴ and R¹ are bonded to each other, a functional group    forming a 5 to 8 membered ring together with the nitrogen atom they    are bonded to (when A⁴ or R¹ and the nitrogen atom they are bonded    to are bonded through a double bond, R² represents the bond between    A⁴ or R¹ and the nitrogen atom.)

When A⁴ represents an aliphatic hydrocarbon group having 1 to 3 carbonatoms, which bridges the nitrogen atom, bonded to R¹ and R², and A³through an identical atom or through different atoms, such as analiphatic hydrocarbon group having 1 to 3 carbon atoms is a bivalentfunctional group derived by removing one hydrogen atom for each bond,from the same carbon atom or two different carbon atoms of a methane, amethene, a propane or a propene. As preferred examples of such A⁴ whichare aliphatic hydrocarbon groups having 1 to 3 carbon atoms, —CH₂—,—(CH₂)₂—, —CH(CH₃)—, —(CH₂)₃—, —C(CH₃)₂— and —CH═CHCH₂— may be cited.

When A⁴ represents a functional group wherein A⁴ and R¹ are bonded toeach other forming a 5 to 8 membered ring together with the nitrogenatom they are bonded to, as examples of such functional groups forming 5to 8 membered rings, monovalent functional groups derived by removingone hydrogen atom from one carbone atom of a pyrrole cycle, an oxazolecycle, an isooxazole cycle, a thiazole cycle, an isothioazole cycle, apyrazole cycle, a pyridine cycle, a pyrazine cycle, a pyrimidine cycle,a pyridazine cycle, an azetidine cycle, a pyrrolidine cycle, apiperidine cycle, a piperazine cycle and a morpholine cycle may becited. When A⁴ or R¹ and the nitrogen atom they are bonded to are bondedthrough a double bond, in other words, when forming a cycle, forexample, such as an oxazole cycle, an isooxazole cycle, a thiazolecycle, an isothioazole cycle, an imidazole cycle, a pyrazole cycle, apyridine cycle, a pyrazine cycle, a pyrimidine cycle and a pyridazinecycle with A⁴, R¹ and the nitrogen atom they are bonded to, R²represents a bond between A⁴ or R¹, and the nitrogen atom. As preferredexamples of such functional groups forming 5 to 8 membered rings, a2-pyrrolidinyl group, a 2-piperidinyl group, a 3-piperidinyl group, a4-piperidinyl group, a 2-piperazinyl group, a 2-morpholinyl group, a2-pyridyl group, a 3-pyridyl group and a 4-pyridyl group may be cited.

As particularly preferred examples of such a functional group for A⁴,the bond representing a single bond, a carbonyl group, —CH₂— and—(CH₂)₂— may be cited. In addition, when representing a functional groupwherein A⁴ and R¹ are bonded to each other forming a 5 to 8 memberedring together with the nitrogen atom they are bonded to, as particularlypreferred examples, a 2-pyridyl group, a 4-pyridyl group and a4-piperidinyl group may be cited.

In the above Formula (1), the combination of functional groups A¹, A²,A³ and A⁴, represented by Formula (A) below,

[In Formula (A), A¹, A², A³, A⁴, and the symbol

have the same definition as above.]A¹, A², A³ and A⁴ may notsimultaneously represent bonds. In addition, when A² represents one ofthe Formula (A2A), Formula (A2B) or Formula (A2C), A² and the nitrogenatom bonded to R¹ and R² must be bonded with more than two carbon atomsin between. As preferred examples of such functional groups, —(CH₂)₃—,—(CH₂)₄—, —(CH₂)₅—, ═CH(CH₂)₂—, ═CH(CH₂)₃—, ═CH(CH₂)₄—, —CH₂CH═CHCH₂—,—NH(CH₂)₂—, —NH(CH₂)₃—, —NH(CH₂)₄—, —N(CH₃)(CH₂)₃—, —CH₂NH(CH₂)₂—,—O(CH₂)₃—, —CH₂O(CH₂)₂—, —S(CH₂)₃—, —CH₂S(CH₂)₂—, -(o-phenylene)-,-(m-phenylene)-, -(p-phenylene)-, —CH₂— (o-phenylene)-,—CH₂—(m-phenylene)-, —CH₂—(p-phenylene)-, —(CH₂)₂-(o-phenylene)-,—(CH₂)₂-(m-phenylene)-, —(CH₂)₂-(p-phenylene)-, -(o-phenylene)-CH₂—,-(m-phenylene)-CH₂—, -(p-phenylene)-CH₂—, -(o-phenylene)-(CH₂)₂—,-(m-phenylene)-(CH₂)₂—, -(p-phenylene)-(CH₂)₂—, —CH₂—(o-phenylene)-CH₂—, —CH₂— (m-phenylene)-CH₂—, —CH₂—(p-phenylene)-CH₂—,—(CH₂)₂CO—, —(CH₂)₃CO—, —(CH₂)₄CO—, ═CHCH₂CO—, ═CH(CH₂)₂CO—,═CH(CH₂)₃CO—, —CH₂CH═CHCO—, —NHCH₂CO—, —NH(CH₂)₂CO—, —NH(CH₂)₃CO—,—N(CH₃)(CH₂)₂CO—, —CH₂NHCH₂CO—, —O(CH₂)₂CO—, —CH₂OCH₂CO—, —S(CH₂)₂CO—,—CH₂SCH₂CO—, -(o-phenylene)-CO—, -(m-phenylene)-CO—, -(p-phenylene)-CO—,—CH₂— (o-phenylene)-CO—, -(o-phenylene)-CH₂CO—, -(m-phenylene)-CH₂CO—,-(p-phenylene)-CH₂CO—, —CH₂— (m-phenylene)-CO— and —CH₂—(p-phenylene)-CO— may be cited.

In the above Formula (1), R¹ and R² may be identical or different andrepresent one of the items 1) to 7) shown below.

-   1) a hydrogen atom,-   2) a substituted or an unsubstituted alkyl group having 1 to 10    carbon atoms (fluorine atom, chlorine atom, bromine atom, iodine    atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms,    aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7    to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms,    sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl    group, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl    group having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, sulfonyl group    having 1 to 6 carbon atoms, cycloalkyl group having 3 to 8 carbon    atoms, phenyl group, and, heterocyclic group (containing 1 to 4    oxygen atoms, nitrogen atoms, or sulfur atoms) may be cited as    substituents),-   3) a substituted or an unsubstituted alicyclic hydrocarbon group    having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon    atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon    atoms, carbamoyl group having 1 to 15 carbon atoms, amino group    having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon    atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group    having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group    having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon    atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited    as substituents),-   4) a substituted or an unsubstituted aromatic hydrocarbon group    having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group having 1 to    4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents)-   6) an acyl group having 1 to 10 carbon atoms when A⁴ is not a    carbonyl group,-   7) a sulfonyl group having 1 to 8 carbon atoms when A⁴ is not a    carbonyl group (however, when either R¹ or R² represents a sulfonyl    group having 1 to 8 carbon atoms, the other may neither be an acyl    group having 1 to 10 carbon atoms nor a sulfonyl group having 1 to 8    carbon atoms), or, when R¹ and R² are bonded together, they    represent a functional group forming a cyclic amino group having 4    to 8 carbon atoms together with the nitrogen atom they are bonded to    (for said cyclic amino group having 4 to 8 carbon atoms, alkyl group    having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents).

As examples of such R¹ and R² which are unsubstituted alkyl groupshaving 1 to 10 carbon atoms, a methyl group, an ethyl group, a propylgroup, an isopropyl group, a butyl group, an isobutyl group, an s-butylgroup, an t-butyl group, a pentyl group, an isopentyl group, a neopentylgroup, a hexyl group, a heptyl group, an octyl group, a nonyl group anda decyl group may be cited.

As examples of unsubstituted cycloalkyl groups having 3 to 8 carbonatoms, a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, acyclohexyl group, a cycloheptyl group and a cyclooctyl group may becited.

As examples of unsubstituted heterocycles, monocyclic or bicyclicfunctional groups such as a furyl group, a thiophenyl group, a pyrrolylgroup, an oxazolyl group, an isooxazolyl group, a thiazolyl group, anisothiazolyl group, an imidazolyl group, a pyrazolyl group, a triazolylgroup, a tetrazolyl group, a pyranyl group, a pyridyl group, a pyrazinylgroup, a pyrimidinyl group, a pyridazinyl group, a benzofuranyl group,an indolyl group, a benzimidazolyl group, a benzothiazolyl group, abenzoxazolyl group, a quinolyl group, an isoquinolyl group, a quinazolylgroup, a purinyl group, a pteridinyl group, an azetidinyl group, apyrrolidinyl group, a morpholino group, a piperidino group andpyperazinyl may be cited.

As examples of substitution groups when R⁵¹, R⁶¹ or R⁶² is a substitutedaliphatic hydrocarbon group having 1 to 10 carbon atoms, a fluorineatom, a chlorine atom, a bromine atom, an iodine atom, a hydroxyl group,alkoxy groups having 1 to 4 carbon atoms which are a methoxy group, anethoxy group, a propoxy group, an isopropoxy group, a butoxy group, ans-butoxy group and a t-butoxy group, aryloxy groups having 6 to 10carbon atoms which are a phenoxy group, a 1-naphthoxy group and a2-naphthoxy group, aralkoxy groups having 7 to 9 carbon atoms such as abenzyloxy group, an α-phenethyloxy group, a β-phenethyloxy group, aphenylpropyloxy group and a cinnamyloxy group, acyloxy groups having 2to 10 carbon atoms such as an acetoxy group, a trifluoroacetoxy group, apropionyloxy group, an isopropionyloxy group, a butyryloxy group, anisobutyryloxy group, an s-butyryloxy group, a valeryloxy group, anisovaleryloxy group, a hexanoyloxy group, a heptanoyloxy group, anoctanoyloxy group, a nonanoyloxy group, a decanoyloxy group, abenzoyloxy group, a phenylacetyloxy group, a cinnamoyloxy group, acyclopentylcarboxy group, a cyclohexylcarboxy group and acycloheptylcarboxy group, sulfonyloxy groups having 1 to 8 carbon atomssuch as a methanesulfonyloxy group, a trifluoromethanesulfonyloxy group,an ethanesulfonyloxy group, a butanesulfonyloxy group, at-butanesulfonyloxy group, a nonafluorobutanesulfonyloxy group, abenzenesulfonyloxy group, a p-bromobenzenesulfonyloxy group, ap-toluenesulfonyloxy group, a benzylsulfonyloxy group, anα-phenethylsulfonyloxy group and a β-phenethylsulfonyloxy group, an oxogroup, a carboxyl group, alkoxycaobonyl groups having 2 to 10 carbonatoms such as a methoxycarbonyl group, an ethoxycarbonyl group, apropoxycarbonyl group, an isopropoxycarbonyl group, a butoxycarbonylgroup, an isobutoxycarbonyl group, an s-butoxycarbonyl group, at-butoxycarbonyl group, a phenoxycarbonyl group, a 1-naphthoxycarbonylgroup, a 2-naphthoxycarbonyl group, a benzyloxycarbonyl group, anα-phenethyloxycarbonyl group and a β-phenethyloxycarbonyl group,carbamoyl groups having 1 to 15 carbon atoms such as a carbamoyl group,an N-methylcarbamoyl group, an N-ethylcarbamoyl group, anN-propylcarbamoyl group, an N-isopropylcarbamoyl group, anN-butylcarbamoyl group, an N-isobutylcarbamoyl group, anN-s-butylcarbamoyl group, an N-t-butylcarbamoyl group, anN-pentylcarbamoyl group, an N-hexylcarbamoyl group, an N-phenylcarbamoylgroup, an N-benzylcarbamoyl group, an N-phenethylcarbamoyl group, anN-cyclopropylcarbamoyl group, an N-cyclobutylcarbamoyl group, anN-cyclopentylcarbamoyl group, an N-cyclohexylcarbamoyl group, anN-cycloheptylcarbamoyl group, an N-cyclopropanemethylcarbamoyl group, anN,N-dimethylcarbamoyl group, an N,N-ethylmethylcarbamoyl group, anN,N-diethylcarbamoyl group, an N,N-dipropylcarbamoyl group, anN,N-dibutylcarbamoyl group, an N,N-dicyclohexylcarbamoyl group, anN,N-diphenylcarbamoyl group, an N,N-dibenzylcarbamoyl group, apiperidinocarbonyl group, and a morpholinocarbonyl group, amino groupshaving 0 to 14 carbon atoms such as an amino group, a methylamino group,an ethylamino group, a propylamino group, an isopropylamino group, abutylamino group, an isobutylamino group, an s-butylamino group, at-butylamino group, a pentylamino group, an hexylamino group, anheptylamino group, an octylamino group, a nonylamino group, a decylaminogroup, a phenylamino group, a benzylamino group, a phenethylamino group,a cyclopropylamino group, a cyclobutylamino group, a cyclopentylaminogroup, a cyclohexylamino group, a cycloheptylamino group, acyclooctylamino group, a cyclopropanemethylamino group, a dimethylaminogroup, an N-ethylmethylamino group, a diethylamino group, an N—methylpropylamino group, an L N-methylisopropylamino group, an N-methylbutylamino group, an N-methyl-t-butylamino group, anN-ethylisopropylamino group, a dipropylamino group, a diisopropylaminogroup, an ethylbutylamino group, an N-methylhexylamino group, adibutylamino group, a dipentylamino group, a dicyclohexylamino group, adiphenylamino group, a dibenzylamino group, a piperidino group and amorpholino group, acylamino groups having 1 to 10 carbon atoms such as aformylamino group, an acetylamino group, a trifluoroacetylamino group, apropionylamino group, a butyrylamino group, an isobutyrylamino group, avalerylamino group, an hexanoylamino group, a benzoylamino group, aphenylacetylamino group, a phenylpropionylamino group, and acinnamoylamino group, sulfonylamino groups having 1 to 8 carbon atomssuch as a methanesulfonylamino group, a trifluoromethanesulfonylaminogroup, an ethanesulfonylamino group, a butanesulfonylamino group, at-butanesulfonylamino group, a nonafluorobutanesulfonylamino group, abenzenesulfonylamino group, a p-bromobenzenesulfonylamino group, ap-toluenesulfonylamino group, a benzylsulfonylamino group, anc-phenethylsulfonylamino group and a β-phenethylsulfonylamino group,imino groups having 1 to 10 carbon atoms such as a methylimino group, anethylimino group, a propylimino group, an isopropylimino group, abutylimino group, an isobutylimino group, a pentylimino group, anhexylimino group, an heptylimino group, an octylimino group, anonylimino group, a decylimino group, a phenylimino group, a benzyliminogroup, a phenethylimino group, a cyclopropylimino group, acyclobutylimino group, a cyclopentylimino group, a cyclohexyliminogroup, and a cycloheptylimino group, a cyano group, a nitro group,sulfide groups having 1 to 6 carbon atoms such as a methylthio group, anethylthio group, a propylthio group, an isopropylthio group, a butylthiogroup, an isobutylthio group, an s-butylthio group, a t-butylthio group,a pentylthio group, an hexylthio group, a phenylthio group, acyclopentylthio group and a cyclohexylthio group, sulfinyl groups having1 to 6 carbon atoms such as a methylsulfinyl group, an ethylsulfinylgroup, a propylsulfinyl group, an isopropylsulfinyl group, abutylsulfinyl group, an isobutylsulfinyl group, an s-butylsulfinylgroup, a t-butylsulfinyl group, a pentylsulfinyl group, a hexylsulfinylgroup, a phenylsulfinyl group, a cyclopentylsulfinyl group, and acyclohexylsulfinyl group, sulfonyl groups having 1 to 6 carbon atomssuch as a methylsulfonyl group, an ethylsulfonyl group, a propylsulfonylgroup, an isopropylsulfonyl group, a butylsulfonyl group, anisobutylsulfonyl group, an s-butylsulfonyl group, a t-butylsulfonylgroup, a pentylsulfonyl group, a hexylsulfonyl group, a phenylsulfonylgroup, a cyclopentylsulfonyl group and a cyclohexylsulfonyl group, asubstituted or unsubstituted cycloalkyl group having 3 to 8 carbon atoms(in addition to the same examples as the examples chosen among theexamples indicated as examples of substitution groups in the case of thepreviously mentioned alkyl group having 1 to 10 carbon atoms, alkylgroups having 1 to 4 carbon atoms which are a methyl group, an ethylgroup, a propyl group, an isopropyl group, a butyl group, an isobutylgroup, an s-butyl and a t-butyl group, acyl groups having 1 to 10 carbonatoms such as a formyl group, an acetyl group, a trifluoroacetyl group,a propionyl group, a butyryl group, an isobutyryl group, a valerylgroup, an hexanoyl group, a benzoyl group, a phenylacetyl group, aphenylpropionyl group and a cinnamoyl group may be cited as examples ofsuch cycloalkyl groups having 3 to 8 carbon atoms), a substituted orunsubstituted phenyl group (as examples of substitution groups for sucha pheyl group, the substitution groups given in the case of thepreviously-mentioned alkyl group having 1 to 10 carbon atoms and thesame examples as the examples chosen among the examples indicated asexamples of substitution groups in the case of the previously-mentionedcycloalkyl groups having 3 to 8 carbon atoms may be cited), asubstituted or unsubstituted heterocyclic group (include 1 to 4 oxygenatoms, nitrogen atoms or sulfur atoms. As examples of substitutiongroups for such a heterocyclic group, the same examples as the exampleschosen among the examples indicated as examples of substitution groupsin the case of the previously-mentioned alkyl group having 1 to 10carbon atoms and in the case of the previously-mentioned cycloalkylgroups having 3 to 8 carbon atoms may be cited) may be cited.

When R¹ or R² represents an acyl group having 1 to 10 carbon atoms, asexamples of such an acyl group having 1 to 10 carbon atoms, a formylgroup, an acetyl group, a trifluoroacetyl group, a propionyl group, abutyryl group, an isobutyryl group, a valeryl group, an hexanoyl group,a benzoyl group, a phenylacetyl group, a phenylpropionyl group and acinnamoyl group may be cited.

When R¹ or ² represents a solfonyl group having 1 to 8 carbon atoms, asexamples of such a solfonyl group having 1 to 8 carbon atoms, amethanesulfonyl group, a trifluoromethanesulfonyl group, anethanesulfonyl group, a butanesulfonyl group, a t-butanesulfonyl group,a nonafluorobutanesulfonyl group, a benzenesulfonyl group, ap-bromobenzenesulfonyl group, a p-toluenesulfonyl group, abenzylsulfonyl group, an α-phenethylsulfonyl group, β-phenethylsulfonylgroup may be cited. As preferred examples of such R¹ and R², a hydrogenatom, a methyl group, an ethyl group, a propyl group, an isopropylgroup, a butyl group, a t-butyl group, a 2-hydroxyethyl group, acarboxymethyl group, a carboxyethyl group, a methoxycarbonylethyl group,a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, acyclohexyl group, a cyclopropylmethyl group, a phenyl group, a tolylgroup, a benzyl group, a phenethyl group, a pyridyl group, a 4-pyridylgroup, a formyl group, an acetyl group, a propanoyl group, a benzoylgroup, a methanesulfonyl group, a benzenesulfonyl group and ap-toluenesulphonyl may be cited.

When representing a functional group wherein R¹ and R² are bonded toeach other and form an amino group having 4 to 8 carbon atoms togetherwith the nitrogen atom they are bonded to, as examples of functionalgroups forming such an amino group having 4 to 8 carbon atoms, anazetidinyl group, a pyrrolidinyl group, a piperidino group, a morpholinogroup, a piperazinyl group and a perhydroazepinyl group may be cited.

As preferred examples of such amino groups formed by R¹, R² and thenitrogen atom they are bonded to, an amino group, a methylamino group,an ethylamino group, a propylamino group, a butylamino group, adimethylamino group, an N-methylamino group, a diethylamino group, adipropylamino group, a diisopropylamino group, a dibutylamino group, anN-methylamino group, a cyclohexylamino group, a phenylamino group, abenzylamino group, a tolylamino group, a (4-pyridylmethyl)amino group, a2-pyridylamino group, a 1-pyrrolidinyl group, a piperidino group, amorpholino group, a 4-N-methylpiperadin-1-yl group, a carboxymethylaminogroup, a 1-carboxyethylamino group, a 2-hydroxyethylamino group, a3-hydroxyethylamino group and a 2-methoxycarbonylethyl group may becited.

In the above Formula (1), the compound represented by the Formula (2)below is a novel substance.

[In Formula (2), the symbol

represents a single bond or a double bond.

G represents one functional group chosen from the group consisting ofthe Formulae (G1), (G2), (G3), (G4), (G5), (G6), (G7), (G8), (G9),(G10), (G11) and (G12) shown below.

(In Formula G1), Formula (G2), Formula (G3), Formula (G4), Formula (G5),Formula (G6), Formula (G7), Formula (G8), Formula (G9), Formula (G10),Formula (G11) and Formula (G12), the symbol

represents the site of linkage with A¹⁰.

R⁴ represents a hydrogen atom, an acyl group having 2 to 10 carbonatoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl groupor a functional group forming the acetal bond together with the oxygenatom bonded to R⁴.

W represents a single bond, —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —CH═CH—,—CH═CHCH₂—, —C═C— or —C≡CCH₂—.

m may be either 0 or 1. However, when W is a single bond, m is equal to1.

R⁵ and R⁶ are either identical or different and, either represent onefunctional group chosen from the following items 1) to 5), i.e.,

-   1) a hydrogen atom,-   2) a substituted or an unsubstituted aliphatic hydrocarbon group    having 1 to 10 carbon atoms (fluorine atom, chlorine atom, bromine    atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents, substituted or unsubstituted alicyclic hydrocarbon    group having 3 to 8 carbon atoms (aliphatic hydrocarbon group having    1 to 6 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents), substituted or    unsubstituted aromatic hydrocarbon group having 6 to 10 carbon atoms    (alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine    atom, bromine atom, iodine atom, hydroxyl group, alkoxy group having    1 to 4 carbon atoms, aryloxy group having 6 to 10 carbon atoms,    aralkoxy group having 7 to 9 carbon atoms, acyloxy group having 2 to    10 carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, cyano group, nitro group, sulfide group having 1 to 6    carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents), and, substituted or unsubstituted heterocyclic group    having 1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms in the    cycle (alkyl group having 1 to 4 carbon atoms, fluorine atom,    chlorine atom, bromine atom, iodine atom, hydroxyl group, alkoxy    group having 1 to 4 carbon atoms, aryloxy group having 6 to 10    carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents) may be cited as substituents),-   3) a substituted or an unsubstituted alicyclic hydrocarbon group    having 3 to 8 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, oxo group, acyl group having 1 to 10 carbon    atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon    atoms, carbamoyl group having 1 to 15 carbon atoms, amino group    having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbon    atoms, sulfonylamino group having 1 to 8 carbon atoms, imino group    having 1 to 10 carbon atoms, cyano group, nitro group, sulfide group    having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon    atoms, and, sulfonyl group having 1 to 6 carbon atoms may be cited    as substituents),-   4) a substituted or an unsubstituted aromatic hydrocarbon group    having 6 to 10 carbon atoms (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group having 1 to    4 oxygen atoms, nitrogen atoms, or sulfur atoms in the cycle (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   or, when R⁵ and R⁶ are bonded to each other, they represent a    substituted or an unsubstituted alicyclic hydrocarbon chain having 4    to 7 carbon atoms (alkyl group having 1 to 4 carbon atoms, fluorine    atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,    alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to    10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, imino group having 1    to 10 carbon atoms, cyano group, nitro group, sulfide group having 1    to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and,    sulfonyl group having 1 to 6 carbon atoms may be cited as    substituents).

R⁷ represents a hydrogen atom, an acyl group having 2 to 10 carbonatoms, a tri(hydrocarbon group having 1 to 7 carbon atoms) silyl group,an alkoxycarbonyl group having 2 to 5 carbon atoms, a sulfonyl grouphaving 1 to 8 carbon atoms, a functional group forming the acetal bondtogether with the oxygen atom bound to R⁷, or, when R⁷ and R⁵ are bondedto each other, it represents one portion of the bond forming thecarbonyl group together with the carbon atom bonded to R⁵ and the oxygenatom bonded to R⁷.

A²⁰ represents a single bond, a Formula (A2A) shown below, a Formula(A2B) shown below or a Formula (A2C) shown below.

(In the formula, R³ represents a hydrogen atom, an alkyl group having 1to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms.)

(In the formula, n represents 0, 1, or 2.)

A¹⁰ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges G and A²⁰ through an identical    atom or through different a toms, and chosen from a group consisting    of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an    alicyclic hydrocarbon group having 3 to 8 carbon atoms, a    heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or    sulfur atoms, and a phenylene group.

A³⁰ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges A²⁰ and A⁴⁰ through an identical    atom or through different atoms, and chosen from a group consisting    of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an    alicyclic hydrocarbon group having 3 to 8 carbon atoms, a    heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or    sulfur atoms, and a phenylene group.

A⁴⁰ represents any of the items 1) to 3) below

-   1) a single bond-   2) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which    bridges the nitrogen atom, bonded to R¹⁰ and R²⁰, and A³⁰ through an    identical atom or through different atoms.-   3) when A⁴⁰ and R¹⁰ are bonded to each other, a functional group    forming a 5 to 8 membered ring together with the nitrogen atom they    are bonded to (when A⁴⁰ or R¹⁰ and the nitrogen atom they are bonded    to are bonded through a double bond, R²⁰ represents the bond between    A⁴⁰ or R¹⁰ and the nitrogen atom.)

However, in the combination of G, A¹⁰, A²⁰, A³⁰, and A⁴⁰ of the aboveFormula (2), when G represents the Formula (G1), and either of A¹⁰ orA³⁰ is a phenylene group, A²⁰ may not be a single bond. In addition,when A²⁰ represents one of the Formula (A2A), Formula (A2B) or Formula(A2C), A²⁰ and the nitrogen atom bonded to R¹⁰ and R²⁰ must be bondedwith more than two carbon atoms in between.

R¹⁰ and R²⁰ are either identical or different, and either represent onefunctional group chosen from the following items 1) to 7), i.e.,

-   1) a hydrogen atom (however, when R¹⁰ and R²⁰ both represent a    hydrogen atom, only in the case where G is equal to Formula (G1)),-   2) when G is not equal to Formula (G7), a substituted or an    unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine    atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,    alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to    10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having    2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms,    amino group having 0 to 14 carbon atoms, acylamino group having 1 to    10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms,    imino group having 1 to 10 carbon atoms, cyano group, nitro group,    sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to    6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms,    cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and,    heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms,    or sulfur atoms) may be cited as substituents),-   3) when G is not equal to Formula (G7), a substituted or an    unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   4) when G is not equal to Formula (G7), a substituted or an    unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group (containing    1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   6) when G is not equal to Formula (G7), an acyl group having 1 to 10    carbon atoms-   7) when G is not equal to Formula (G7), a sulfonyl group having 1 to    8 carbon atoms (however, when either R¹⁰ or R²⁰ represents a    sulfonyl group having 1 to 8 carbon atoms, the other may be neither    an acyl group having 1 to 10 carbon atoms nor a sulfonyl group    having 1 to 8 carbon atoms),-   or, when R¹⁰ and R²⁰ are bonded together, they represent a    functional group forming a cyclic amino group having 4 to 8 carbon    atoms together with the nitrogen atom they are bonded to (for said    cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1    to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents)].

The same examples given for G in the above Formula (1) may be cited aspreferred examples for G in the above Formula (2).

In the above Formula (2), A²⁰ represents a single bond, a Formula (A2A)shown below, a Formula (A2B) shown below or a Formula (A2C) shown below.

[In the formula, R³ represents a hydrogen atom, an alkyl group having 1to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms.]

[In the formula, n represents 0, 1, or 2.]

The same examples given as concrete examples for R³ in the above Formula(1) may be cited as concrete examples for R³ in the above Formula (A2B).

In the above Formula (A2C), n represents 0, 1, or 2. However, 0 may becited as the preferred value for n.

A single bond, —O—, —NH—, —N(CH₃)— and —S— may be cited as suchpreferred functional groups for A²⁰.

A¹⁰ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges G and A²⁰ through an identical    atom or through different atoms, and chosen from a group consisting    of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an    alicyclic hydrocarbon group having 3 to 8 carbon atoms, a    heterocyclic group having 1 or 2 oxygen atoms, nitrogen atoms, or    sulfur atoms, and a phenylene group.

The same examples given as concrete examples for A¹ in the above Formula(1) may be cited as such concrete examples for A¹⁰. A bond representinga single bond, —CH₂—, —(CH₂)₂—, =CH— and ═CHCH₂— may be cited asparticularly preferred functional groups.

In the above Formula (2), A³⁰ represents the items 1) or 2) below

-   1) a single bond-   2) a functional group which bridges A²⁰ and A⁴⁰ through an identical    atom or through different atoms, and chosen from a group consisting    of an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an    alicyclic hydrocarbon group having 3 to 8 carbon atoms, a    heterocyclic group f having 1 or 2 oxygen atoms, nitrogen atoms, or    sulfur atoms, and a phenylene group.

The same examples given as concrete examples for A³ in the above Formula(1) may be cited as concrete examples for A³⁰. A bond representing asingle bond, —CH₂—, —(CH₂)₂— and —CH═CH— may be cited as particularlypreferred functional groups.

In the above Formula (2), A⁴⁰ represents any of the items 1) to 3) below

-   1) a single bond-   2) an aliphatic hydrocarbon group having 1 to 3 carbon atoms, which    bridges the nitrogen atom, bonded to R¹⁰ and R²⁰, and A³⁰ through an    identical atom or through different atoms.-   3) when A⁴⁰ and R¹⁰ are bonded to each other, a functional group    forming a 5 to 8 membered ring together with the nitrogen atom they    are bonded to (when A⁴⁰ or R¹⁰ and the nitrogen atom they are bonded    to are bonded through a double bond, R²⁰ represents the bond between    A⁴⁰ or R¹⁰ and the nitrogen atom.). The same examples given as    concrete examples for A⁴ in the above Formula (1) may be cited as    such concrete examples for A⁴⁰. A bond representing a single bond,    —CH₂— and —(CH₂)₂— may be cited as particularly preferred functional    groups. In addition, when A⁴⁰ and R¹⁰ are bonded to each other, to    represent a functional group forming a 5 to 8 membered ring together    with the nitrogen atom they are bonded to, 2-pyridyl, 4-pyridyl and    4-piperidinyl may be cited as particularly preferred examples.

However, in the combination of G, A¹⁰, A²⁰, A³⁰, and A⁴⁰, when Grepresents the Formula (G1), and either of A¹⁰ or A³⁰ is a phenylenegroup, A²⁰ may not be a single bond. In addition, when A²⁰ representsone of the Formula (A2A), Formula (A2B) or Formula (A2C), A²⁰ and thenitrogen atom bonded to R¹⁰ and R²⁰ must be bonded with more than twocarbon atoms in between.

In the above Formula (2), as preferred examples of functional groupsrepresented by the Formula (A0) below,

[In Formula (A0), A¹⁰, A²⁰, A³⁰, A⁴⁰, and the symbol

have the same definition as above.]

-   —(CH₂)₃—, —(CH₂)₄—, —(CH₂)₅—, =CH(CH₂)₂—, =CH(CH₂)₃—, =CH(CH₂)₄—,    —CH₂CH═CHCH₂—, —NH(CH₂)₂—, —NH(CH₂)₃—, —NH(CH₂)₄—, —N(CH₃)(CH₂)₃—,    —CH₂NH(CH₂)₂—, —O(CH₂)₃—, —CH₂O(CH₂)₂—, —S(CH₂)₃— and —CH₂S(CH₂)₂—    may be cited.

In the above Formula (2), R¹⁰ and R²⁰ are either identical or different,and either represent one functional group chosen from the followingitems 1) to 7), i.e.,

-   1) a hydrogen atom (however, when R¹⁰ and R²⁰ both represent a    hydrogen atom, only in the case where G is equal to Formula (G1)),-   2) when G is not equal to Formula (G7), a substituted or an    unsubstituted alkyl group having 1 to 10 carbon atoms (fluorine    atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,    alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to    10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy    group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8    carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having    2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms,    amino group having 0 to 14 carbon atoms, acylamino group having 1 to    10 carbon atoms, sulfonylamino group having 1 to 8 carbon atoms,    imino group having 1 to 10 carbon atoms, cyano group, nitro group,    sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1 to    6 carbon atoms, sulfonyl group having 1 to 6 carbon atoms,    cycloalkyl group having 3 to 8 carbon atoms, phenyl group, and,    heterocyclic group (containing 1 to 4 oxygen atoms, nitrogen atoms,    or sulfur atoms) may be cited as substituents),-   3) when G is not equal to Formula (G7), a substituted or an    unsubstituted cycloalkyl group having 3 to 8 carbon atoms (alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   4) when G is not equal to Formula (G7), a substituted or an    unsubstituted phenyl group (alkyl group having 1 to 4 carbon atoms,    fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl    group, alkoxy group having 1 to 4 carbon atoms, aryloxy group having    6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,    acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having    1 to 8 carbon atoms, acyl group having 1 to 10 carbon atoms,    carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,    carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to    14 carbon atoms, acylamino group having 1 to 10 carbon atoms,    sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitro    group, sulfide group having 1 to 6 carbon atoms, sulfinyl group    having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6 carbon    atoms may be cited as substituents),-   5) a substituted or an unsubstituted heterocyclic group (containing    1 to 4 oxygen atoms, nitrogen atoms, or sulfur atoms, and, alkyl    group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,    bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to    4 carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy    group having 7 to 9 carbon atoms, acyloxy group having 2 to 10    carbon atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo    group, acyl group having 1 to 10 carbon atoms, carboxyl group,    alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group    having 1 to 15 carbon atoms, amino group having 0 to 14 carbon    atoms, acylamino group having 1 to 10 carbon atoms, sulfonylamino    group having 1 to 8 carbon atoms, imino group having 1 to 10 carbon    atoms, cyano group, nitro group, sulfide group having 1 to 6 carbon    atoms, sulfinyl group having 1 to 6 carbon atoms, and, sulfonyl    group having 1 to 6 carbon atoms may be cited as substituents),-   6) when G is not equal to Formula (G7), an acyl group having 1 to 10    carbon atoms-   7) when G is not equal to Formula (G7), a sulfonyl group having 1 to    8 carbon atoms (however, when either R¹⁰ or R²⁰ represents a    sulfonyl group having 1 to 8 carbon atoms, the other may neither be    an acyl group having 1 to 10 carbon atoms nor a sulfonyl group    having 1 to 8 carbon atoms),-   or, when R¹⁰ and R²⁰ are bonded together, they represent a    functional group forming a cyclic amino group having 4 to 8 carbon    atoms together with the nitrogen atom they are bonded to (for said    cyclic amino group having 4 to 8 carbon atoms, alkyl group having 1    to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom,    iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon    atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group    having 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon    atoms, sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl    group having 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl    group having 2 to 10 carbon atoms, carbamoyl group having 1 to 15    carbon atoms, amino group having 0 to 14 carbon atoms, acylamino    group having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8    carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,    nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl    group having 1 to 6 carbon atoms, and, sulfonyl group having 1 to 6    carbon atoms may be cited as substituents).

As concrete examples of R¹⁰ and R²⁰, the same examples as the examplesgiven in the above Formula (1) as concrete examples may be cited, and,as particularly preferred examples, a hydrogen atom, a methyl group, anethyl group, a propyl group, an isopropyl group, a butyl group, at-butyl group, a 2-hydroxyethyl group, a 3-hydroxyethyl group, acarboxymethyl group, a carboxyethyl group, a methoxycarbonylethyl group,a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, acyclohexyl group, a cyclopropylmethyl group, a phenyl group, a tolylgroup, a benzyl group, a phenethyl group, a pyridyl group, a 4-pyridylgroup, a formyl group, an acetyl group, a propanoyl group, a benzoylgroup, a methanesulfonyl group, a benzenesulfonyl group and ap-toluenesulfonyl may be cited.

When representing a functional group wherein R¹ and R² are bonded toeach other and form an amino group having 4 to 8 carbon atoms togetherwith the nitrogen atom they are bonded to, as examples of functionalgroups forming such an amino group having 4 to 8 carbon atoms, the sameexamples as the examples given in the above Formula (1) as concreteexamples of R¹ and R² may be cited.

As preferred examples of such amino groups formed by R¹⁰, R²⁰ and thenitrogen atom they are bonded to, an amino group, a methylamino group,an ethylamino group, a propylamino group, a butylamino group, adimethylamino group, an N-methylamino group, a diethylamino group, adipropylamino group, a diisopropylamino group, a dibutylamino group, anN-methylamino group, a cyclohexylamino group, a phenylamino group, abenzylamino group, a tolylamino group, a (4-pyridylmethyl)amino group, a2-pyridylamino group, a 1-pyrrolidinyl group, a piperidino group, amorpholino group, a 4-N-methylpiperidin-1-yl group, a carboxymethylaminogroup, a 1-carboxyethylamino group, a 2-hydroxyethylamino group, and a3-hydroxyethylamino group may be cited.

There are instances where the nitrogen-containing compound representedby the above Formula (1) may form salts. No particular restrictionexists for such salts provided they are pharmacologically accepted.Concretely, mineral acid salts such as hydrochlorides, hydrobromates,hydroiodates, phosphates, nitrates, and sulfates, organic sulfonatessuch as methane sulfonates, 1-hydroxyethane sulfonates, andp-toluenesulfonates, and, organic carboxylates such as acetates,trifluoroacetates, propionates, oxalates, malonates, succinates,glutarates, adipinates, tartrates, maleates, malates and mendelates maybe included as added acidic salts, and, salts formed with inorganicbases such as sodium salts, potassium salts, magnesium salts, calciumsalts, inorganic salt groups such as aluminium salts, and, salts formedwith organic bases such as methylamine salts, ethylamine salts, lysinesalts, and ornithin salts may be cited as salts made with bases.

Concrete examples of the nitrogen-containing compounds represented bythe above Formula (1) provided by the present invention will be given inthe following. However, the invention is not limited to these examples.

-   1)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   2) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   3)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   4)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   5)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   6) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   7)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   8) (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   9) (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   10) (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   11) (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   12)    (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   13) (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   14)    (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   15)    (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   16)    (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   17)    (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   18)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   19)    (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   20)    (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   21) (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo [3.3.0]-2-octene-   22) (1S,5S,6R,7R)-3-(47N,N-dibutylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   23)    (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   24) (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   25)    (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   26) (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   27)    (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   28)    (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   29)    (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   30)    (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   31)    (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   32)    (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   33)    (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   34)    (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   35)    (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   36)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   37)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   38)    (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   39)    (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   40)    (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   41)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   42)    (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   43)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl-]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   44)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   45)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-1-bicyclo[3.3.0]-2-octene-   46)    (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   47)    (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   48)    (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   49)    (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   50)    (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   51)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   52)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   53)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   54)    (1S,5S,6R,7R)-3-[N-(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   55)    (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   56) (1S,5S,6    R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]haminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   57)    (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   58)    (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   59)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   60)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   61)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   62)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   63)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   64)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   65)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   66)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   67)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   68)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   69)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   70)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   71)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   72)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   73)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   74)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   75)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   76)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   77)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   78)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   79)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   80)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   81)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   82)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   83)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   84)    (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   85)    (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   86)    (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   87)    (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   88)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene.-   89) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,5S,    1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   90)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   91)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   92)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   93) (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,5    S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   94)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   95)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   96)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   97)    (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   98)    (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   99)    (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   100)    (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   101)    (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   102)    (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   103)    (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   104)    (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   105)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   106)    (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   107)    (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   108)    (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   109)    (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   110)    (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   111)    (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   112)    (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   113)    (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   114)    (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   115)    (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   116)    (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   117) (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(3S,5S,    1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   118)    (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   119)    (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   120)    (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   121)    (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   122)    (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   123)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   124)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   125)    (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   126)    (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   127)    (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   128)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,5S,    1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   129)    (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   130)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   131)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   132)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   133)    (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   134)    (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   135)    (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   136) (1S,5S,6    R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   137)    (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   138)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(3S,5S,8E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   139)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(3S,5S,    1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   140)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   141)    (1S,3S,6R,7R)₃-[N—(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   142)    (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   143)    (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   144)    (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   145)    (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   146)    (1S,3S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   147)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   148)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   149)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   150)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   151)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   152)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   153)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   154)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   155)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   156)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   157)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   158)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   159)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   160)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   161)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   162)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   163)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(3S,5S,    1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   164)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   165)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   166)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   167)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   168)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(3S,5S,    1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   169)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   170)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   171)    (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   172)    (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   173)    (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   174)    (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   175)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   176)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-1-octenyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   177) (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   178)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   179)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   180)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   181) (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   182)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   183)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   184)    (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   185) (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(4S,    E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   186)    (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   187) (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   188)    (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   189)    (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   190)    (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]7-hydroxybicyclo[3.3.0]-2-octene-   191)    (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   192) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   193)    (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   194)    (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   195)    (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   196)    (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   197) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(4S,1    E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   198)    (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   199)    (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   200)    (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   201)    (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   202)    (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   203)    (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   204)    (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   205)    (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   206)    (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   207)    (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   208)    (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   209)    (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   210)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo    (3.3.0]-2-octene-   211)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   212)    (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   213) (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(4S,    E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   214)    (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   215)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   216)    (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   217)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   218)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   219)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   220)    (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   221)    (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbarmoylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   222)    (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   223)    (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   224)    (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   225)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   226)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoyethyl)-N-methylaminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   227)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   228)    (1S,5S,6R,7R)-3-[N—(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   229)    (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   230)    (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   231)    (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   232)    (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   233)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   234)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   235)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   236)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   237)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   238)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   239) (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   240)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   241)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   242)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(4S,4E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   243)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   244)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   245)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   246)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   247)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   248)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   249)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   250)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   251)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   252)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   253)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   254)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   255) (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]    thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   256)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   257)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   258)    (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   259)    (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   260)    (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   261)    (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   262)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[33.0]-2-octene-   263)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   264)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   265)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   266)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   267)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   268)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   269)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   270)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   271)    (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   272)    (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   273)    (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   274)    (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   275)    (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   276)    (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   277)    (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   278)    (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   279)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   280)    (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   281) (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(3S,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   282)    (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   283)    (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   284)    (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   285)    (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   286)    (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   287)    (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   288)    (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   289)    (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   290)    (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   291)    (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   292)    (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   293)    (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   294)    (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   295)    (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   296)    (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   297)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   298)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   299) (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(3S,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   300)    (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   301)    (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   302)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   303)    (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3S,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   304)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   305)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   306)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   307)    (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   308)    (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   309)    (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   310)    (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   311)    (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   312)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   313)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   314)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminoethyl-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   315)    (1S,5S,6R,7R)-3-[N—(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   316)    (1S,3S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   317)    (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   318)    (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   319)    (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   320)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   321)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   322)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   323)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   324)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   325)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   326)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   327)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   328)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   329)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   330)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   331)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   332)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   333)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   334)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   335)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   336) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]    thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   337)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   338)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   339)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   340)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   341)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   342)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   343)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   344)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   345)    (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   346)    (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   347)    (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   348)    (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   349)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   350)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   351)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   352)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   353)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   354)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 355)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   356)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   357)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   358)    (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   359)    (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   360)    (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   361)    (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   362)    (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   363)    (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   364)    (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   365)    (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   366) (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,    E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   367)    (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   368)    (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   369)    (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   370)    (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   371) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(3R,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   372)    (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   373)    (1S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   374)    (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   375)    (1S,5S,6R,7R)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   376)    (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   377)    (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   378)    (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   379)    (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   380)    (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   381)    (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   382)    (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   383)    (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   384) (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoy8-pentyl)-6-[(3R,    E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   385)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   386)    (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   387)    (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   388)    (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   389)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   390)    (1S,5S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   391)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-pentenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   392)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   393)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   394)    (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(3R,9E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   395)    (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   396)    (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   397)    (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   398)    (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   399)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   400)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   401)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   402)    (1S,5S,6R,7R)-3-[N—(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   403)    (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   404)    (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   405)    (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   406)    (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   407)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   408)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   409)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   410)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   411)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   412)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   413)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   414)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   415)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   416)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   417)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   418)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   419)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   420)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(3R,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   421)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   422)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   423) (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]    thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   424)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   425)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   426)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   427)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   428)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   429)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   430)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   431)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   432)    (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   433)    (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   434)    (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   435)    (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   436)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   437)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   438)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   439)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   440)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   441)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   442)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   443)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(E)-4-(m-tolyl)—butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   444)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   445)    (1S,5S,6R,7R)-3-(4-N-methylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   446)    (1S,5S,6R,7R)-3-(4-N-ethylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   447)    (1S,5S,6R,7R)-3-(4-N-propylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   448)    (1S,5S,6R,7R)-3-(4-N-isopropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   449)    (1S,5S,6R,7R)-3-(4-N-butylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   450)    (1S,5S,6R,7R)-3-(4-N-t-butylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   451)    (1S,5S,6R,7R)-3-(4-N-phenylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   452)    (1S,5S,6R,7R)-3-(4-N-benzylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   453) (1S,5S    6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   454)    (1S,5S,6R,7R)-3-[4-(4-N-methyl-1-piperazinyl)carbonylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   455)    (1S,5S,6R,7R)-3-[4-N-(2-pyridyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   456)    (1S,5S,6R,7R)-3-(4-N,N-dipropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   457)    (1S,5S,6R,7R)-3-(4-N,N-dibutylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   458)    (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   459)    (1S,5S,6R,7R)-3-[4-N-(2-hydroxyethyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   460)    (1S,5S,5S,6R,7R)-3-[4-N-(3-hydroxypropyl)carbamoylbutyl]-6-[(E)-4-(m-tolyl)—butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   461)    (1S,5S,6R,7R)-3-(3-carbamoylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   462)    (1S,5S,6R,7%)-3-(3-N,N-dimethylcarbamoylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   463)    (1S,5S,6R,7R)-3-(3-N,N-diisopropylcarbamoylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   464)    (1S,5S,6R,7R)-3-(3-N-t-butyl-N-methylcarbamoylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   465)    (1S,5S,6R,7R)-3-[3-(1-pyrrolidinyl)carbonylpropyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   466)    (1S,5S,6R,7R)-3-(3-piperidinocarbonylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   467)    (1S,5S,6R,7R)-3-(3-morpholinocarbonylpropyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   468)    (1S,5S,6R,7R)-3-(5-carbamoylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   469)    (1S,5S,6R,7R)-3-(5-N,N-dimethylcarbamoylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   470)    (1S,5S,6R,7R)-3-(5-N,N-diisopropylcarbamoylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   471)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylcarbamoylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   472)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)carbonylpentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   473)    (1S,5S,6R,7R)-3-(5-piperidinocarbonylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   474)    (1S,5S,6R,7R)-3-(5-morpholinocarbonylpentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   475)    (1S,5S,6R,7R)-3-[(1Z)-3-N,N-dimethylcarbamoyl-1-propenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   476)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   477)    (1S,1S,6R,7R)-3-[(1E)-4-N,N-dimethylcarbamoyl-1-butenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   478)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylcarbamoyl-1-pentenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   479)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   480)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   481)    (1S,5S,6R,7R)-3-[N-(2-N,N-diisopropylcarbamoylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   482)    (1S,5S,6R,7R)-3-[N-(2-N-t-butyl-N-methylcarbamoylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   483)    (1S,5S,6R,7R)-3-[N-[2-(1-pyrrolidinyl)carbonylethyl]aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   484)    (1S,5S,6R,7R)-3-[N-(2-piperidinocarbonylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   485)    (1S,5S,6R,7R)-3-[N-(2-morpholinocarbonylethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   486)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylcarbamoylpropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   487)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylcarbamoylethyl)-N-methylaminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   488)    (1S,5S,6R,7R)-3-[N—(N,N-dimethylcarbamoylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   489)    (1S,5S,6R,7R)-3-[N—(N,N-diisopropylcarbamoylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   490)    (1S,5S,6R,7R)-3-[N-(N-t-butyl-N-methylcarbamoylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   491)    (1S,5S,6R,7R)-3-[2-N-[(1-pyrrolidinyl)carbonylmethyl]aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   492)    (1S,5S,6R,7R)-3-[2-N-(piperidinocarbonylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   493)    (1S,5S,6R,7R)-3-[2-N-(morpholinocarbonylmethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   494)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylcarbamoylethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   495)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   496)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   497)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   498)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinyl)carbonylethyl]oxymethyl]-6-[(E)-4-(m-tolyl)    1-butenyl]-7-hydroxybicyclo [3.3.0]-2-octene-   499)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   500)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   501)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   502)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   503)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   504)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   505)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   506)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   507)    (1S,5S,6R,7R)-3-[(2-N,N-dimethylcarbamoylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   508)    (1S,5S,6R,7R)-3-[(2-N,N-diisopropylcarbamoylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   509)    (1S,5S,6R,7R)-3-[(2-N-t-butyl-N-methylcarbamoylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   510)    (1S,5S,6R,7R)-3-[[2-(1-pyrrolidinylcarbonyl)ethyl]thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   511)    (1S,5S,6R,7R)-3-[(2-piperidinocarbonylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   512)    (1S,5S,6R,7R)-3-[(2-morpholinocarbonylethyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   513)    (1S,5S,6R,7R)-3-[2-(N,N-dimethylcarbamoylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   514)    (1S,5S,6R,7R)-3-[2-(N,N-diisopropylcarbamoylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   515)    (1S,5S,6R,7R)-3-[2-(N-t-butyl-N-methylcarbamoylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   516)    (1S,5S,6R,7R)-3-[2-[(1-pyrrolidinyl)carbonylmethyl]thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   517)    (1S,5S,6R,7R)-3-[2-(piperidinocarbonylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   518)    (1S,5S,6R,7R)-3-[2-(morpholinocarbonylmethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   519)    (1S,5S,6R,7R)-3-[(2-carbamoylphenyl)methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   520)    (1S,5S,6R,7R)-3-[(4-carbamoylphenyl)methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   521)    (1S,5S,6R,7R)-3-[2-(3-carbamoylphenyl)ethyl]-6-[(E)-4-(m-tolyl)-2-butenyl-7-hydroxybicyclo[3.3.0]-2-octene-   522)    (1S,5S,6R,7R)-3-[2-[3-(piperidinocarbonyl)phenyl]ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   523)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   524)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   525)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   526)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   527)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   528)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   529)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   530)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   531)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   532) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,5R,1E)-3-hydroxy-5-methyl]-nonenyl group-   533)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   534)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   535)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   536)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   537)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(4R,1E)-4-hydroxy-4-methyl]-octenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   538)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   539)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   540)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   541)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   542) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (4R,1E)-4-hydroxy-4-methyl-1-octenyl group-   543) (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,4S,    1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]7-hydroxybicyclo[3.3.0]-2-octene-   544)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   545)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   546)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   547)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   548)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   549)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   550)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   551)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   552) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group-   553)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   554)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   555)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   556)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   557)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   558)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   559)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   560)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   561)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   562) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group-   563)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-    7-hydroxybicyclo[3.3.0]-2-octene-   564)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1    propenyl]-7-hydroxybicyclo [3.3.0]-2-octene-   565)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1    propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   566)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   567)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   568)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   569)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   570)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   571)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   572) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group-   573)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   574)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   575)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   576)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   577)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   578)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   579)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   580)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   581)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   582) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group-   583)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   584)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   585)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   586)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   587)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   588)    (S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   589)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   590)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   591)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   592) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group-   593)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   594) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,    1E)-3-hydroxy-3-phenyl-1 propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   595)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3R,1E)—hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   596)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   597)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   598)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   599)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   600)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   601) (1S,5S,6    R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   602) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group-   603)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   604)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   605)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   606)    (1S,5S,6R,7R)-3-[4-N-(2-methoxycarbonylethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   607)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   608)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   609)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   610)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   611)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   612) compounds of compound numbers 10 to 87 of the examples given    bove, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group-   613)    (1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   614)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   615)    (1S,5S,6R,7R)-3-(4-N,N-diethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   616)    (1S,5S,6R,7R)-3-[4-N-(2-ethoxycarbonylethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   617)    (1S,5S,6R,7R)-3-[4-N-(4-pyridylmethyl)carbamoylbutyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   618)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   619)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)carbonylbutyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   620)    (1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   621)    (1S,5S,6R,7R)-3-(4-morpholinocarbonylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   622) compounds of compound numbers 10 to 87 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is a    substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3R,1E)-3-hydroxy-1-octenyl group-   623)    (1S,5S,6R,7S)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   624)    (1S,5S,6R,7S)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   625)    (1R,5R,6S,7S)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   626)    (1R,5R,6S,7S)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   627)    (1R,5R,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   628) (1R,5R,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   629)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-hydroxy-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   630)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   631)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   632)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   633)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   634)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   635)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   636)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   637)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   638)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   639)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   640)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   641) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R;    1E)-3-hydroxy-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   642)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   643)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   644)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   645)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   646)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   647)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-(3-ethylcyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   648)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3(3-ethylcyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   649)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   650)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   651)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   652)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   653)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   654)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   655)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   656)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   657)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   658)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   659)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   660) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   661)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   662)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   663)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   664)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   665)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   666)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   667)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   668)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   669)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   670) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,    1E)-3-hydroxy-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   671)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   672)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   673)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   674)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   675)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   676)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(4-N,N-dimethylaminophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   677)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(4-N,N-dimethylaminophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   678)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-(3-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   679)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(3-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   680) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3    hydroxy-4-1(4-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   681)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(4-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   682)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   683)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   684)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   685)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   686)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   687)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   688)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   689)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   690)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-3(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   691)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-3(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   692)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   693)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   694)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-3-methyl-5(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   695)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-3-methyl-5(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   696)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   697) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1    E)-3-hydroxy-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   698)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E,5Z)-3-hydroxy-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   699)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E,5Z)-3-hydroxy-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   700)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   701)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   702)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl--6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   703)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl--6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   704)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4,4-dimethyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   705)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4,4-dimethyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   706)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl--6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   707)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   708)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   709)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   710)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   711)    (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-1-octynyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   712)    (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-1-octynyl]-7-hydroxybicyclo[3.3.0]-2-octene-   713) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,    1Z)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   714)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1Z)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   715)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxyoctyl]-7-hydroxybicyclo[3.3.0]-2-octene-   716)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxyoctyl]-7-hydroxybicyclo[3.3.0]-2-octene-   717)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-3-methyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene-   718)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-3-methyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene-   719) (1S,5    S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-4,4-dimethyloctyl]7-hydroxybicyclo[3.3.0]-2-octene-   720)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-4,4-dimethyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene-   721)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-3-phenylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene-   722)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-3-phenylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene-   723)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-4-phenylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene-   724)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-4-phenylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene-   725)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-4-(m-tolyl)butyl]-7-hydroxybicyclo[3.3.0]-2-octene-   726)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-4-(m-tolyl)butyl]-7-hydroxybicyclo[3.3.0]-2-octene-   727)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S)-3-hydroxy-3-cyclopentylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene-   728)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R)-3-hydroxy-3-cyclopentylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene-   729) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,    1E)-4-hydroxy-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   730)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   731)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-hydroxy-4-butyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   732) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,    1E)-4-hydroxy-4-butyl-1,5-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   733) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,    1E)-4-hydroxy-4-butyl-1,5-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   734)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-cyclopentyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   735) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,    1E)-4-hydroxy-4-cyclopentyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   736)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-cyclohexyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   737)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-cyclohexyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   738)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   739)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-4-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   740)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-(1-hydroxycyclopentyl)-1-propenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   741) (1S,5S    6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-(1-hydroxycyclohexyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   742)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   743)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-4-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   744)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-1-octenyl]-7    hydroxybicyclo[3.3.0]-2-octene-   745)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   746)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,5S)-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   747)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,5R)-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   748)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E,5S)-5-methyl-1,3-nonadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   749)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E,5R)-5-methyl-1,3-nonadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   750)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,4R)-5-methyl-1,3-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   751)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,4S)-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   752)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-4-methyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   753)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,5R)-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   754)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,4S)-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   755)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-4-ethyl-1,3-octadienyl    j-7-hydroxybicyclo[3.3.0]-2-octene-   756)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-butyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   757)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,5Z)-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   758)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E,5Z)-1,3,5-octatrienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   759)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-cyclopentyliden-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   760)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-cyclohexyliden-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   761)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-2-phenylvinyl]-7-hydroxybicyclo[3.3.0]-2-octene-   762)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-2-(o-tolyl)vinyl]-7-hydroxybicyclo[3.3.0]-2-octene-   763)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-2-(m-tolyl)vinyl]-7-hydroxybicyclo[3.3.0]-2-octene-   764)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-2-(p-tolyl)vinyl]-7-hydroxybicyclo[3.3.0]-2-octene-   765)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   766)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   767) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)    4-phenyl-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   768)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3t)-4-phenyl-3-methyl-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   769)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   770)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   771)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   772)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-4-(m-tolyl)-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   773)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   774)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(31E,3E)-5-(m-tolyl)-3-pentadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   775)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-4,4-bisphenylsufonyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-octene-   776)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E,3E)-5-(m-tolyl)-1,3-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   777)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(4-phenoxybutyl)-7-hydroxybicyclo[3.3.0]-2-octene-   778)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   779)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-S-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   780)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   781)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   782)    (S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   783)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   784)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   785)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   786)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-3-oxo-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   787)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4R,1E)-3-oxo-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   788)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   789)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(5S,1E)-3-oxo-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   790)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(5R,1E)-3-oxo-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   791)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   792) (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1    E)-3-oxo-3-cyclohexyl-1 propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   793) (1S,5    S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   794)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   795)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-phenyl-propenyl]7-hydroxybicyclo[3.3.0]-2-octene-   796)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   797)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   798)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   799) (1S,5    S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   800)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   801)    (1S,58,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   802)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   803)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   804)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-5-(o-tolyl)-1-pentenyl]7-hydroxybicyclo[3.3.0]-2-octene-   805)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   806)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1E)-3-oxo-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   807)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-hydroxymethyl-7-hydroxybicyclo[3.3.0]-2-octene-   808)    (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-hydroxyethyl]-7-hydroxybicyclo[3.3.0]-2-octene-   809)    (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxyethyl]-7-hydroxybicyclo[3.3.0]-2-octene-   810)    (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene-   811) (1S,5S    6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene-   812)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxy-1-methylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene-   813)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxy-1-methylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene-   814) (1    S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R,2E)—hydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   815)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S,2E)-1-hydroxy-2-nonenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   816)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R,3S,2E)-1,3-dihydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   817)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S,3S,2E)-1,3-dihydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   818)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R,3S,2E)-1,3-dihydroxy-4-cyclopentyl-2-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   819)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S,3S,2E)-1,3-dihydroxy-4-cyclopentyl-2-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   820)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R,3S,2E)-1,3-dihydroxy-5-phenyl-2-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   821)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S,3S,2E)-1,3-dihydroxy-5-phenyl-2-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   822)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxy-2-pentynyl]-7-hydroxybicyclo[3.3.0]-2-octene-   823)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxy-2-pentynyl]-7-hydroxybicyclo[3.3.0]-2-octene-   824)    (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1R)-1-hydroxy-5-phenoxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene-   825)    (1S,5S,6S,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(1S)-1-hydroxy-5-phenoxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene-   826)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxyphenylmethyl]-7-hydroxybicyclo[3.3.0]-2-octene-   827)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxyphenylmethyl]-7-hydroxybicyclo[3.3.0]-2-octene-   828)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(o-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   829)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(o-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   830)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(m-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   831)    (1S,5S,6R,7R)-5-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(m-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   832)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(p-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   833)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(p-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   834)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(4-methoxyphenyl)    methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   835)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(4-methoxyphenyl)    methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   836)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(4-N,N-dimethylaminophenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   837)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(4-N,N-dimethylaminophenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   838)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(R)-hydroxy(3-chlorophenyl)    methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   839)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(S)-hydroxy(3-chlorophenyl)    methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   840)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-formyl-7-hydroxybicyclo[3.3.0]-2-octene-   841)    (1S,3S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-acetyl-7-hydroxybicyclo[3.3.0]-2-octene-   842) (1    S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-benzoyl-7-hydroxybicyclo[3.3.0]-2-octene-   843)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(o-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene-   844)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(m-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene-   845)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(p-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene-   846)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(4-methoxyphenylcarbonyl)-7-hydroxybicyclo[3.3.0]-2-octene-   847)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-(4-N,N-dimethylaminophenyl    carbonyl)-7-hydroxybicyclo[3.3.0]-2-octene-   848) (1S,5S,6R,7R)-3-(4-N,N-dimethyl    carbamoylbutyl)-6-(3-chlorophenylcarbonyl)-7-hydroxybicyclo[3.3.0]-2-octene-   849)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-phenylvinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   850)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(4-methoxyphenyl)vinyl    carbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   851)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(4-N,N-dimethylamino    phenyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   852)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(3-chlorophenyl)vinyl    carbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   853)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(2-thienyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   854)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(2E)-2-(4-pyridyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   855) compounds of compound numbers 623 to 854 of the examples given    above, wherein the 4-N,N-dimethylcarbamoylbutyl group, which is a    substitution group at position 3 of the bicyclo[3.3.0]-2-octene    cycle, has been replaced by either of the 4-carbamoylbutyl group,    the 4-N,N-diethylcarbamoylbutyl group, the    4-N-(2-methoxycarbonylethyl)carbamoylbutyl group, the    4-N-(4-pyridylmethyl)carbamoylbutyl group, the    4-N,N-diisopropylcarbamoylbutyl group, the    4-(1-pyrrolidinyl)carbonylbutyl group, the 4-piperidinocarbonylbutyl    group or the 4-morpholinocarbonylbutyl group-   856)    (1S,2R,3R,5S)-7-[(E)-4-carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   857)    (1S,2R,3R,5S)-7-[(E)-4-N-methylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   858)    (1S,2R,3R,5S)-7-[(E)-4-N-ethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   859)    (1S,2R,3R,5S)-7-[(E)-4-N-propylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   860)    (1S,2R,3R,5S)-7-[(E)-4-N-isopropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   861)    (1S,2R,3R,5S)-7-[(E)-4-N-butylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   862)    (1S,2R,3R,5S)-7-[(E)-4-N-t-butylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   863)    (1S,2R,3R,5S)-7-[(E)-4-N-phenylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   864)    (1S,2R,3R,5S)-7-[(E)-4-N-benzylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   865)    (1S,2R,3R,5S)-7-[(E)-4-N-(4-pyridylmethyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   866)    (1S,2R,3R,5S)-7-[(E)-4-(1-pyrrolidinyl)carbonylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   867)    (1S,2R,3R,5S)-7-[(E)-4-piperidinocarbonylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]3-hydroxybicyclo[3.3.0]octane-   868)    (1S,2R,3R,5S)-7-[(E)-4-morpholinocarbonylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   869)    (1S,2R,3R,5S)-7-[(E)-4-(4-N-methyl-1-piperazinyl)carbonylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   870)    (1S,2R,3R,5S)-7-[(E)-4-N-(2-pyridyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   871) (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,    1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   872)    (1S,2R,3R,5S)-7-[(E)-4-N,N-diethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   873)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dipropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo    [3.3.0]octane-   874)    (1S,2R,3R,5S)-7-[(E)-4-N,N-diisopropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   875)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dibutylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   876)    (1S,2R,3R,5S)-7-[(E)-4-N-t-butyl-N-methylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   877)    (1S,2R,3R,5S)-7-[(E)-4-N-(2-hydroxyethyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   878)    (1S,2R,3R,5S)-7-[(E)-4-N-(3-hydroxypropyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   879)    (1S,2R,3R,5S)-7-[(E)-3-carbamoylpropylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   880)    (1S,2R,3R,5S)-7-[(E)-3-N,N-dimethylcarbamoylpropylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   881)    (1S,2R,3R,5S)-7-[(E)-5-carbamoylpentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   882)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylcarbamoylpentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   883)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   884)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-diisopropylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   885)    (1S,2R,3R,5S)-7-[(E)-2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   886)    (1S,2R,3R,5S)-7-[(E)-2-[(1-pyrrolidinyl)carbonylmethyl]oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   887)    (1S,2R,3R,5S)-7-[(E)-2-(piperidinocarbonylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   888)    (1S,2R,3R,5S)-7-[(E)-2-(morpholinocarbonylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   889)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)thioethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   890)    (1S,2R,3R,5S)-7-[(E)-2-N—(N,N-dimethylcarbamoylmethyl)aminoethylidene]-2-[(3S,1E)3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   891)    (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethoxymethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   892)    (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethylthiomethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   893)    (1S,2R,3R,5S)-7-[(E)-N—(N,N-dimethylcarbamoylmethyl)aminomethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   894)    (1S,2R,3R,5S)-7-[(E)-4-carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   895)    (1S,2R,3R,5S)-7-[(E)-4-N-methylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   896)    (1S,2R,3R,5S)-7-[(E)-4-N-ethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   897)    (1S,2R,3R,5S)-7-[(E)-4-N-propylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   898)    (1S,2R,3R,5S)-7-[(E)-4-N-isopropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   899)    (1S,2R,3R,5S)-7-[(E)-4-N-butylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   900)    (1S,2R,3R,5S)-7-[(E)-4-N-t-butylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-0.3-hydroxybicyclo[3.3.0]octane-   901)    (1S,2R,3R,5S)-7-[(E)-4-N-phenylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   902)    (1S,2R,3R,5S)-7-[(E)-4-N-benzylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   903)    (1S,2R,3R,5S)-7-[(E)-4-N-(4-pyridylmethyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   904)    (1S,2R,3R,5S)-7-[(E)-4-(1-pyrrolidinyl)carbonylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   905)    (1S,2R,3R,5S)-7-[(E)-4-piperidinocarbonylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   906)    (1S,2R,3R,5S)-7-[(E)-4-morpholinocarbonylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.6]octane-   907)    (1S,2R,3R,5S)-7-[(E)-4-(4-N-methyl-1-piperazinyl)carbonylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   908)    (1S,2R,3R,5S)-7-[(E)-4-N-(2-pyridyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   909)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   910)    (1S,2R,3R,5S)-7-[(E)-4-N,N-diethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   911)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dipropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   912)    (1S,2R,3R,5S)-7-[(E)-4-N,N-diisopropylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   913)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dibutylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   914)    (1S,2R,3R,5S)-7-[(E)-4-N-t-butyl-N-methylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   915)    (1S,2R,3R,5S)-7-[(E)-4-N-(2-hydroxyethyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   916)    (1S,2R,3R,5S)-7-[(E)-4-N-(3-hydroxypropyl)carbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   917)    (1S,2R,3R,5S)-7-[(E)-3-carbamoylpropylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   918)    (1S,2R,3R,5S)-7-[(E)-3-N,N-dimethylcarbamoylpropylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   919)    (1S,2R,3R,5S)-7-[(E)-5-carbamoylpentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   920)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylcarbamoylpentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   921)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   922)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-diisopropylcarbamoylmethyl)-oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]    octane-   923)    (1S,2R,3R,5S)-7-[(E)-2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethylidene]-2-[(3S,1E)3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   924)    (1S,2R,3R,5S)-7-[(E)-2-[(1-pyrrolidinyl)carbonylmethyl]oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]    octane-   925)    (1S,2R,3R,5S)-7-[(E)-2-(piperidinocarbonylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   926)    (1S,2R,3R,5S)-7-[(E)-2-(morpholinocarbonylmethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo(3.3.0]octane-   927)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)thioethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   928)    (1S,2R,3R,5S)-7-[(E)-2-N—(N,N-dimethylcarbamoylmethyl)aminoethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   929)    (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethoxymethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   930)    (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethylthiomethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   931) (1S,2R    3R,5S)-7-[(E)-N—(N,N-dimethylcarbamoylmethyl)aminomethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   932) (1S,2R,3R,5S)-7-[(E)-4-carbamoylbutylidene]-2-[(3S,4S,    1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   933)    (1S,2R,3R,5S)-7-[(E)-4-N-methylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   934)    (1S,2R,3R,5S)-7-[(E)-4-N-ethylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   935) (1S,2R,3R,5S)-7-[(E)-4-N-propylcarbamoylbutylidene]-2-[(3S,4S,    1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   936)    (1S,2R,3R,5S)-7-[(E)-4-N-isopropylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]    octane-   937) (1S,2R,3R,5S)-7-[(E)-4-N-butylcarbamoylbutylidene]-2-[(3S,4S,    1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   938)    (1S,2R,3R,5S)-7-[(E)-4-N-t-butylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   939) (1S,2R,3R,5S)-7-[(E)-4-N-phenylcarbamoylbutylidene]-2-[(3S,4S,    1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   940)    (1S,2R,3R,5S)-7-[(E)-4-N-benzylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   941) (1    S,2R,3R,5S)-7-[(E)-4-N-(4-pyridylmethyl)carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   942)    (1S,2R,3R,5S)-7-[(E)-4-(1-pyrrolidinyl)carbonylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   943)    (1S,2R,3R,5S)-7-[(E)-4-piperidinocarbonylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   944)    (1S,2R,3R,5S)-7-[(E)-4-morpholinocarbonylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   945)    (1S,2R,3R,5S)-7-[(E)-4-(4-N-methyl-1-piperazinyl)carbonylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo    [3.3.0]octane-   946)    (1S,2R,3R,5S)-7-[(E)-4-N-(2-pyridyl)carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   947)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   948)    (1S,2R,3R,5S)-7-[(E)-4-N,N-diethylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   949)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dipropylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   950)    (1S,2R,3R,5S)-7-[(E)-4-N,N-diisopropylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   951)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dibutylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   952)    (1S,2R,3R,5S)-7-[(E)-4-N-t-butyl-N-methylcarbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   953)    (1S,2R,3R,5S)-7-[(E)-4-N-(2-hydroxyethyl)carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   954)    (1S,2R,3R,5S)-7-[(E)-4-N-(3-hydroxypropyl)carbamoylbutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   955)    (1S,2R,3R,5S)-7-[(E)-3-carbamoylpropylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]    octane-   956)    (1S,2,R,3R,5S)-7-[(E)-3-N,N-dimethylcarbamoylpropylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   957)    (1S,2R,3R,5S)-7-[(E)-5-carbamoylpentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   958)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylcarbamoylpentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   959)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   960)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-diisopropylcarbamoylmethyl)oxyethylidene]-2-[(3S,4S,1E)3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   961)    (1S,2R,3R,5S)-7-[(E)-2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   962)    (1S,2R,3R,5S)-7-[(E)-2-[(1-pyrrolidinyl)carbonylmethyl]oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   963)    (1S,2R,3R,5S)-7-[(E)-2-(piperidinocarbonylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   964)    (1S,2R,3R,5S)-7-[(E)-2-(morpholinocarbonylmethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   965)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)thioethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   966)    (1S,2R,3R,5S)-7-[(E)-2-N-(N,N-dimethylcarbamoylmethyl)aminoethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   967)    (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethoxymethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   968)    (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethylthiomethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   969)    (1S,2R,3R,5S)-7-[(E)-N—(N,N-dimethylcarbamoylmethyl)aminomethylene]-2-[(3S,4S,    1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   970)    (1S,2R,3R,5S)-7-[(E)-4-carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   971)    (1S,2R,3R,5S)-7-[(E)-4-N-methylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   972) (1S,2R,3R,5S)-7-[(E)-4-N-ethylcarbamoylbutylidene]-2-[(3S,4R,    1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   973)    (1S,2R,3R,5S)-7-[(E)-4-N-propylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]    octane-   974)    (1S,2R,3R,5S)-7-[(E)-4-N-isopropylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   975)    (1S,2R,3R,5S)-7-[(E)-4-N-butylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   976)    (1S,2R,3R,5S)-7-[(E)-4-N-t-butylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo    [3.3.0]octane-   977)    (1S,2R,3R,5S)-7-[(E)-4-N-phenylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   978)    (1S,2R,3R,5S)-7-[(E)-4-N-benzylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   979)    (1S,2R,3R,5S)-7-[(E)-4-N-(4-pyridylmethyl)carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   980)    (1S,2R,3R,5S)-7-[(E)-4-(1-pyrrolidinyl)carbonylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   981)    (1S,2R,3R,5S)-7-[(E)-4-piperidinocarbonylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   982)    (1S,2R,3R,5S)-7-[(E)-4-morpholinocarbonylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   983)    (1S,2R,3R,5S)-7-[(E)-4-(4-N-methyl-1-piperazinyl)carbonylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   984)    (1S,2R,3R,5S)-7-[(E)-4-N-(2-pyridyl)carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   985)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   986)    (1S,2R,3R,5S)-7-[(E)-4-N,N-diethylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   987)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dipropylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   988)    (1S,2R,3R,5S)-7-[(E)-4-N,N-diisopropylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   989)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dibutylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   990)    (1S,2R,3R,5S)-7-[(E)-4-N-t-butyl-N-methylcarbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   991)    (1S,2R,3R,5S)-7-[(E)-4-N-(2-hydroxyethyl)carbamoylbutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   992)    (1S,2R,3R,5S)-7-[(E)-4-N-(3-hydroxypropyl)carbamoylbutyldene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   993)    (1S,2R,3R,5S)-7-[(E)-3-carbamoylpropylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   994)    (1S,2R,3R,5S)-7-[(E)-3-N,N-dimethylcarbamoylpropylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   995)    (1S,2R,3R,5S)-7-[(E)-5-carbamoylpentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   996)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylcarbamoylpentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   997)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   998)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-diisopropylcarbamoylmethyl)oxyethylidene]-2[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   999)    (1S,2R,3R,5S)-7-[(E)-2-(N-t-butyl-N-methylcarbamoylmethyl)oxyethylidene]-2[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-5-enyl]-3-hydroxybicyclo[3.3.0]octane-   1000)    (1S,2R,3R,5S)-7-[(E)-2-[(1-pyrrolidinyl)carbonylmethyl]oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   1001)    (1S,2R,3R,5S)-7-[(E)-2-(piperidinocarbonylmethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   1002)    (1S,2R,3R,5S)-7-[(E)-2-(morpholinocarbonylmethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   1003)    (1S,2R,3R,5S)-7-[(E)-2-(N,N-dimethylcarbamoylmethyl)thioethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   1004)    (1S,2R,3R,5S)-7-[(E)-2-N—(N,N-dimethylcarbamoylmethyl)aminoethylidene]-2[(3S,4R,    1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   1005)    (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethoxymethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   1006)    (1S,2R,3R,5S)-7-[(E)-N,N-dimethylcarbamoylmethylthiomethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   1007)    (1S,2R,3R,5S)-7-[(E)-N—(N,N-dimethylcarbamoylmethyl)aminomethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   1008) compounds of compound numbers 856 to 893 of the examples given    above, wherein the (3S,1E)-3-hydroxy-1-octenyl group which is a    substitution group bonded to the carbon at position 12 of the    prostacyclin carbon identification number, has been replaced by    either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (E)-4-(m-tolyl)-1-butenyl group, the    (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the    (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the    (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group, or, the    (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group or the    2-(1-hydroxycyclohexyl)ethynyl group-   1009)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-carbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1010) (1R,2R,3aS,8bS)-2,3,3a,    8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N-methylcarbamoylpropyl)-1H-cyclopenta    [b] benzofuran-   1011)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-ethylcarbamoylpropyl)-1H-cyclopenta    [b]benzofuran-   1012)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-propylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1013)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-isopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1014)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1015)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-t-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1016) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,    1E)-3-hydroxy-1-octenyl]-5-(3-N-phenylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1017)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(3-N-benzylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1018)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-N-(4-pyridylmethyl)carbamoylpropyl]-1H-cyclopenta[b]    benzofuran-   1019)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-(1-pyrrolidinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran-   1020)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-piperidinocarbonylpropyl)-1H-cyclopenta[b]benzofuran-   1021)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-morpholinocarbonylpropyl)-1H-cyclopenta[b]benzofuran-   1022)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-(4-N-methyl-1-piperazinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran-   1023)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-N-(2-pyridyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1024)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N,N-dimethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1025)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N,N-diethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1026)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N,N-dipropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1027)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N,N-diisopropylcarbamoylpropyl)-1H-cyclopenta    [b]benzofuran-   1028)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N,N-dibutylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1029)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N-t-butyl-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1030)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-N-(2-hydroxyethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1031)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[3-N-(3-hydroxypropyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1032)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(2-carbamoylethyl)-1H-cyclopenta[b]benzofuran-   1033)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(2-N,N-dimethylcarbamoylethyl)-1H-cyclopenta[b]benzofuran-   1034)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-carbamoylbutyl)-1H-cyclopenta[b]benzofuran-   1035)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N,N-dimethylcarbamoylbutyl)-1H-cyclopenta    [b]benzofuran-   1036)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(2-N,N-dimethylcarbamoylethyloxy)-1H-cyclopenta[b]benzofuran-   1037)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-carbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1038)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1039)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-ethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1040)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-propylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1041)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-isopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1042)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1043)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-t-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1044)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-phenylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1045)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-benzylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1046)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(4-pyridylmethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1047)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-(1-pyrrolidinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran-   1048)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-piperidinocarbonylpropyl)-1H-cyclopenta[b]benzofuran-   1049) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,    1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-morpholinocarbonylpropyl)-1H-cyclopenta[b]benzofuran-   1050)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-(4-N-methyl-1-piperazinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran-   1051)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(2-pyridyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1052)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylcarbamoylpropyl)-1H-cyclopenta[b]    benzofuran-   1053)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-diethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1054)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dipropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1055)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-diisopropylcarbamoylpropyl)-1H-cyclopenta    [b]benzofuran-   1056) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,    1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dibutylcarbamoylpropyl)-1H-cyclopenta[b]    benzofuran-   1057)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-t-butyl-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1058) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,    1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(2-hydroxyethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1059)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(3-hydroxypropyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1060)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-carbamoylethyl)-1H-cyclopenta    [b]benzofuran-   1061)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-N,N-dimethylcarbamoylethyl)-1H-cyclopenta[b]    benzofuran-   1062)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-carbamoylbutyl)-1H-cyclopenta[b]benzofuran-   1063)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dimethylcarbamoylbutyl)-1H-cyclopenta[b]benzofuran-   1064)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-N,N-dimethylearbamoylethyloxy)-1H-cyclopenta[b]benzofuran-   1065)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-carbamoylpropyl)-1H-cyclopenta    (b]benzofuran-   1066)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1067)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-ethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1068)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-propylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1069)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-isopropylcarbamoylpropyl)-1H-cyclopenta    [b] benzofuran-   1070)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1071)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-t-butylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1072)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-phenylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1073)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-benzylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1074)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(4-pyridylmethyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1075)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-(1-pyrrolidinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran-   1076)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-piperidinocarbonylpropyl)-1H-cyclopenta[b]benzofuran-   1077)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-morpholinocarbonylpropyl)-1H-cyclopenta[b]benzofuran-   1078)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-(4-N-methyl-1-piperazinyl)carbonylpropyl]-1H-cyclopenta[b]benzofuran-   1079)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(2-pyridyl)carbamoylpropyl]-1H-cyclopenta[b]benzofuran-   1080)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1081)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-diethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1082)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dipropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1083)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-diisopropylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1084)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dibutylcarbamoylpropyl)-1H-cyclopenta    [b] benzofuran-   1085)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N-t-butyl-N-methylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran-   1086)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(2-hydroxyethyl)carbamoylpropyl]-01H-cyclopenta[b]benzofuran-   1087)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[3-N-(3-hydroxypropyl)carbamoylpropyl]-1H-cyclopenta    [b]benzofuran-   1088)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-carbamoylethyl)-1H-cyclopenta    [b]benzofuran-   1089)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-N,N-dimethylcarbamoylethyl)-1H-cyclopenta    [b]benzofuran-   1090)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-carbamoylbutyl)-1H-cyclopenta[b]benzofuran-   1091)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dimethylcarbamoylbutyl)-1H-cyclopenta    [b]benzofuran-   1092)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(2-N,N-dimethylcarbamoylethyloxy)-1H-cyclopenta[b]benzofuran-   1093) compounds of compound numbers 1009 to 1036 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group bonded to the carbon at position 12 of the    prostacyclin carbon identification number, has been replaced by    either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (E)-4-(m-tolyl)-1-butenyl group, the    (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group, the    (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the    (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the    (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group or the    (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group-   1094)    (1S,2R,3R,5S)-7-[(Z)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1095)    (1R,5S,7R,8R)-3-(4-N,N-dimethylcarbamoylbutyl)-8-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1096)    (1S,2R,3R,5S,7R)-7-(4-N,N-dimethylcarbamoylbutyl)-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1097)    (1S,2R,3R,5S,7R)-7-[2-(N,N-dimethylaminocarbamoylmethoxy)ethyl]-2-[(3R,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-3-hydroxybicyclo[3.3.0]octane-   1098)    (1S,3S,5R,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-oxabicyclo[3.3.0]octane-   1099)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-oxabicyclo[3.3.0]-3-octen-   1100)    (1S,5R,6R,7R)-3-[(Z)-4-N,N-dimethylcarbamoylbutylidene]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-4-oxo-2-oxabicyclo[3.3.0]octane-   1101)    (1S,3S,5R,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-thiabicyclo[3.3.0]octane-   1102)    (1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-azabicyclo[3.3.0]-2-octene-   1103)    (1S,3S,5R,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-azabicyclo[3.3.0]octane-   1104) compounds of compound numbers 1094 to 1103 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group bonded to the carbon at position 12 of the    prostacyclin carbon identification number, has been replaced by    either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (E)-4-(m-tolyl)-1-butenyl group, the    (3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group, the    (3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group, the    (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group, the    (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the    (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the    (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group or the    (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group-   1105)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1106)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1107)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1108)    (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1109)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1110)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1111)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1112)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1113)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1114)    (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1115)    (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1116)    (1S,5S,6R,7R)-3-(5-N-propylaminopentyl-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1117)    (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1118)    (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1119)    (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1120)    (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1121)    (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1122)    (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1123)    (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1124)    (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1125) (1S,5S,6R,7R)-3-(5-N,N-    dibutylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1126)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1127)    (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]7-hydroxybicyclo[3.3.0]-2-octene-   1128)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1129)    (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1130)    (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1131)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1132)    (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1133)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1134)    (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1135)    (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1136)    (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1137)    (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1138)    (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1139)    (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1140)    (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1141)    (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1142)    (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1143)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1144)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1145)    (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1146)    (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1147)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1148)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1149)    (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1150)    (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1151)    (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1152)    (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1153)    (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1154)    (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(3S,1E)-3-hydroxy    1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1155)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1156)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1157)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1158)    (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1159)    (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1160)    (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1161)    (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1162)    (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1163)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1164)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1165)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1166)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1167)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1168)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1169)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo([3.3.0]-2-octene-   1170)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-76-hydroxybicyclo[3.3.0]-2-octene-   1171)    (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(3S,    E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1172)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1173)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1174)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1175)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1176)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1177)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(3S,    1E)-3-hydroxy-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1178)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1179)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1180) (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo [3.3.0]-2-octene-   1181)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1182)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1183)    (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1184)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1185) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(3S,    1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1186)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1187)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1188)    (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1189)    (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1190)    (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1191)    (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1192)    (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1193)    (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1194)    (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1195)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1196)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1197)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-octene-   1198)    (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(3S,5S,1    E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1199)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1200)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1201)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1202)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1203)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]7-hydroxybicyclo[3.3.0]-2-octene-   1204)    (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1205)    (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]7-hydroxybicyclo    [3.3.0]-2-octene-   1206)    (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1207)    (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1208)    (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1209)    (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1210)    (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1211    (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1212)    (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1213)    (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1214)    (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1215)    (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1216)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1217)    (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1218)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1219)    (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1220)    (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1221)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1222) (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(3S,5    S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1223)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1224)    (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1225)    (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1226)    (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1227) (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl-6-[(3S,5S,    1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1228)    (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1229)    (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1230)    (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl]hexyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1231)    (1S,5S,6R,7R)-37(6-piperidinohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1232)    (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1233)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1234)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1235)    (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1236)    (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1237)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1238)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1239)    (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1240) (1S,5S,6R,7R)-3-[N-(3    N-t-butyl-N-methytaminopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1241)    (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1242)    (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1243)    (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1244)    (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1245)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1246)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1247)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1248)    (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1249)    (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1250)    (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1251)    (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1252)    (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1253)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1254)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1255)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1256)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1257)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1258)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl]-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1259) (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[3S,    5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1260)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1261)    (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1262)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1263)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1264)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1265)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1266)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1267)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1268)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1269)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1270)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1271)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1272)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(3S,5S,    1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1273)    (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1274)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1275)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1276)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1277)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1278)    (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1279)    (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1280)    (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1281)    (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1282)    (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]7-hydroxybicyclo[3.3.0]-2-octene-   1283)    (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1284)    (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1285)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1286)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1287)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1288)    (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1289)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1290)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1291)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl-7-hydroxybicyclo[3.3.0]-2-octene-   1292)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1293) (1S,    5S,6R,7R)-3-(5-morpholinopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1294)    (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1295)    (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1296)    (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1297)    (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1298)    (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1299)    (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1300)    (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1301)    (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1302)    (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1303)    (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1304)    (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1305)    (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1306)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1307)    (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1308)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1309)    (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1310)    (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1311)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1312)    (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1313)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1314)    (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1315)    (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1316)    (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1317)    (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1318)    (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1319)    (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1320)    (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1321)    (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1322)    (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1323)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1324)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1325)    (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1326) (1S,5S,6R,7R)-3-[(1    Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1327)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1328)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1329)    (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1330)    (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1331)    (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1332)    (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1333)    (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1334)    (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1335)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(4S,1E)₄-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1336)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1337)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1338)    (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1339)    (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1340)    (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1341)    (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1342)    (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1343)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1344)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1345)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1346)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1347)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1348)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1349)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1350)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1351)    (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1352)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1353)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1354)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1355)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1356)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1357)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1358)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1359)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1360)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1361)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1362)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1363)    (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1364)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1365) (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1366) (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(4S,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1367)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1368)    (1-S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1369)    (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1370)    (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1371)    (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1372)    (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1373)    (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1374)    (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1375)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1376)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1377)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1378)    (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1379)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1380)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1381)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1382)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-4-(M-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1383)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1384)    (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1385)    (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1386)    (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1387) (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(3S,1    E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1388)    (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1389)    (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1390)    (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1391)    (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1392)    (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1393)    (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1394) (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(3S,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1395)    (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1396)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1397)    (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1398)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1399)    (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1400)    (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1401)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1402)    (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1403)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1404)    (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1405)    (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1406)    (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene 1407)    (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1408)    (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1409) (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(3S,1    E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1410)    (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1411)    (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1412)    (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1413)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1414)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1415)    (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1416)    (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1417)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1418)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1419)    (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1420)    (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1421)    (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1422)    (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1423)    (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1424)    (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1425)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1426)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1427)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(3S,7E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1428)    (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1429)    (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1430)    (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1431)    (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1432)    (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1433)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1434)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1435)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1436)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1437)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1438)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1439)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1440)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1441)    (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1442)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1443)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1444)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1445)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1446)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1447)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1448)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1449)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1450)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1451)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1452)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1453)    (1S,5S,6R,7R)-3-[2-(2-N-t-butyl-N-methylaminoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1454) (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]    thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1455)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1456)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1457)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1458)    (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1459)    (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1460)    (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1461)    (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1462)    (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1463)    (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1464)    (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1465)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1466)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1467)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1468)    (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1469)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1470)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1471)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1472)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1473)    (1S,5S,6R,1R)-3-(5-morpholinopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1474)    (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1475)    (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1476)    (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1477)    (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-hydroxybicyclo[3.3.0]-2-octene-   1478)    (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1479)    (1S,5S,6R,7R)-3-(5-N-t-butylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1480)    (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1481)    (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1482) (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(3R,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1483)    (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1484)    (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1485)    (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1486)    (1S,5S,6R,7R)-3-(5-N-t-butyl-N-methylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene.-   1487)    (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1488)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1489)    (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1490)    (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1491)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1492)    (1S,5S,6R,7R)-3-(4-N-t-butyl-N-methylaminobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1493)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1494)    (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1495)    (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1496)    (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1497)    (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1498)    (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1499) (1S,5S,6R,7R)-3-(6-N-t-butyl-N-methylaminohexyl)-6-[(3R,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1500)    (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1501)    (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1502)    (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1503) (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(3R,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1504)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1505)    (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1506)    (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1507)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1508)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1509)    (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1510)    (1S,5S,6R,7R)-3-[N-(3-N-t-butyl-N-methylaminopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1511)    (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1512)    (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1513)    (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1514)    (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1515)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1516)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1517)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1518)    (1S,5S,6R,7R)-3-[2-N-(2-N-t-butyl-N-methylaminoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1519)    (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1520)    (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1521)    (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1522)    (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1523)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1524)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1525)    (1S,5S,6R,7R)-3-[(3-N-t-butyl-N-methylaminopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1526)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1527)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1528)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1529)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1530)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1531)    (1S,5S,6R,7R)-3-[2-(2-N—t-butyl-N-methylaminoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1532)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1533)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1534)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1535)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1536)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1537)    (1S,5S,6R,7R)-3-[(3-N—t-butyl-N-methylaminopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1538)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1539)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1540)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1541)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1542)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(3R,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1543)    (1S,5S,6R,7R)-3-[2-(2-N—t-butyl-N-methylaminoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1544)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1545)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1546)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)thioethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1547)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1548)    (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1549)    (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1550)    (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1551) (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]ethyl]-6-[(3R,    1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1552)    (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1553)    (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1554)    (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1555)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]2-octene-   1556) (1S,5    S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1557)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(E)-4-(m-tolyl)-1-buten    yl]-7-hydroxy bicyclo[3.3.0]-2-octene-   1558)    (1S,5S,6R,7R)-3-[5-N-(2-methoxycarbonylethyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1559)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1560)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1561)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1562)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1563)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene.-   1564)    (1S,5S,6R,7R)-3-(5-N-methylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1565)    (1S,5S,6R,7R)-3-(5-N-ethylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1566)    (1S,5S,6R,7R)-3-(5-N-propylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1567)    (1S,5S,6R,7R)-3-(5-N-isopropylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1568)    (1S,5S,6R,7R)-3-(5-N-butylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1569)    (1S,5S,6R,7R)-3-(5-N—t-butylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1570)    (1S,5S,6R,7R)-3-(5-N-phenylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1571)    (1S,5S,6R,7R)-3-(5-N-benzylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1572)    (1S,5S,6R,7R)-3-[5-(4-N-methyl-1-piperazinyl)pentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1573)    (1S,5S,6R,7R)-3-[5-N-(2-pyridyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1574)    (1S,5S,6R,7R)-3-(5-N,N-dipropylaminopentyl)-6-[(E)-4-(m-olyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1575)    (1S,5S,6R,7R)-3-(5-N,N-dibutylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1576)    (1S,5S,6R,7R)-3-(5-N—t-butyl-N-methylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1577)    (1S,5S,6R,7R)-3-[5-N-(2-hydroxyethyl)aminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1578) (1    S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl-6-[(E)-4-(m-tolyl)—butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1579)    (1S,5S,6R,7R)-3-(4-aminobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]2-octene-   1580)    (1S,5S,6R,7R)-3-(4-N,N-dimethylaminobutyl)-6-[(E)-4-(m-tolyl)-S-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1581)    (1S,5S,6R,7R)-3-(4-N,N-diisopropylaminobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1582)    (1S,5S,6R,7R)-3-(4-N—t-butyl-N-methylaminobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1583)    (1S,5S,6R,7R)-3-[4-(1-pyrrolidinyl)butyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1584)    (1S,5S,6R,7R)-3-(4-piperidinobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1585)    (1S,5S,6R,7R)-3-(4-morpholinobutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1586)    (1S,5S,6R,7R)-3-(6-aminohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1587)    (1S,5S,6R,7R)-3-(6-N,N-dimethylaminohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1588)    (1S,5S,6R,7R)-3-(6-N,N-diisopropylaminohexyl)-6-[(E)-4-(m-tolyl)-8-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1589)    (1S,5S,6R,7R)-3-(6-N—t-butyl-N-methylaminohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1590)    (1S,5S,6R,7R)-3-[6-(1-pyrrolidinyl)hexyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1591)    (1S,5S,6R,7R)-3-(6-piperidinohexyl)-6-[(E)-4-S(m-tolyl)—butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1592)    (1S,5S,6R,7R)-3-(6-morpholinohexyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1593)    (1S,5S,6R,7R)-3-[(1Z)-4-N,N-dimethylamino-1-butenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1594)    (1S,5S,6R,7R)-3-[(1Z)-5-N,N-dimethylamino-1-pentenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1595)    (1S,5S,6R,7R)-3-[(1E)-5-N,N-dimethylamino-1-pentenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1596)    (1S,5S,6R,7R)-3-[(1Z)-6-N,N-dimethylamino-1-hexenyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1597)    (1S,5S,6R,7R)-3-[N-(2-N,N-dimethylaminoethyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1598)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1599)    (1S,5S,6R,7R)-3-[N-(3-N,N-diisopropylaminopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1600)    (1S,5S,6R,7R)-3-[N-(3-N—t-butyl-N-methylaminopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1601)    (1S,5S,6R,7R)-3-[N-[3-(1-pyrrolidinyl)propyl]aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1602)    (1S,5S,6R,7R)-3-[N-(3-piperidinopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1603)    (1S,5S,6R,7R)-3-[N-(3-morpholinopropyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1604)    (1S,5S,6R,7R)-3-[N-(4-N,N-dimethylaminobutyl)aminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1605)    (1S,5S,6R,7R)-3-[N-(3-N,N-dimethylaminopropyl)-N-methylaminomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1606)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-dimethylaminoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1607)    (1S,5S,6R,7R)-3-[2-N-(2-N,N-diisopropylaminoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1608)    (1S,5S,6R,7R)-3-[2-N-(2-N—t-butyl-N-methylaminoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1609)    (1S,5S,6R,7R)-3-[2-N-[2-(1-pyrrolidinyl)ethyl]aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1610)    (1S,5S,6R,7R)-3-[2-N-(2-piperidinoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1611)    (1S,5S,6R,7R)-3-[2-N-(2-morpholinoethyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1612)    (1S,5S,6R,7R)-3-[2-N-(3-N,N-dimethylaminopropyl)aminoethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1613)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1614)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1615)    (1S,5S,6R,7R)-3-[(3-N—t-butyl-N-methylaminopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1616)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1617)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1618)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)oxymethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1619)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1620)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1621)    (1S,5S,6R,7R)-3-[2-(2-N—t-butyl-N-methylaminoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1622)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1623)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1624)    (1S,5S,6R,7R)-3-[2-(2-morpholinoethyl)oxyethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1625)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1626)    (1S,5S,6R,7R)-3-[(3-N,N-diisopropylaminopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1627)    (1S,5S,6R,7R)-3-[(3-N—t-butyl-N-methylaminopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1628)    (1S,5S,6R,7R)-3-[[3-(1-pyrrolidinyl)propyl]thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1629)    (1S,5S,6R,7R)-3-[(3-piperidinopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1630)    (1S,5S,6R,7R)-3-[(3-morpholinopropyl)thiomethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1631)    (1S,5S,6R,7R)-3-[2-(2-N,N-dimethylaminoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1632)    (1S,5S,6R,7R)-3-[2-(2-N,N-diisopropylaminoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1633)    (1S,5S,6R,7R)-3-[2-(2-N—t-butyl-N-methylaminoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1634)    (1S,5S,6R,7R)-3-[2-[2-(1-pyrrolidinyl)ethyl]thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1635)    (1S,5S,6R,7R)-3-[2-(2-piperidinoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1636)    (1S,5S,6R,7R)-3-[2-(Z-morpholinoethyl)thioethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1637)    (1S,5S,6R,7R)-3-[(3-N,N-dimethylaminophenyl)methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1638)    (1S,5S,6R,7R)-3-[[2-(aminomethyl)phenyl]methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1639)    (1S,5S,6R,7R)-3-[[4-(aminomethyl)phenyl]methyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1640)    (1S,5S,6R,7R)-3-[2-[3-(aminomethyl)phenyl]ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1641) (1S,5S,6R,7R)-3-[2-[3-(piperidinomethyl)phenyl]    ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1642)    (1S,5S,6R,7R)-3-[2-(4-piperidyl)ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1643)    (1S,5S,6R,7R)-3-[2-(4-pyridyl)ethyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo [3.3.0]-2-octene-   1644)    (1S,5S,6R,7R)-3-[4-(2-pyridyl)butyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1645)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1646)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1647)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1648)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1649)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1650)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1651)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1652)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1653)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl]7-hydroxybicyclo[3.3.0]-2-octene-   1654) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group-   1655)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1656)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1657)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1658)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(4R,1E)-4-hydroxy-4-methyl]-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1659) (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(4R,    1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1660)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1661)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(4R,1E)-4-hydroxy    4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1662)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1663)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(4R,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1664) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (4R,1E)-4-hydroxy-4-methyl-1-octenyl group-   1665)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1666)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1667)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1668)    (1S,5S,6R,7R)-3-[S—N-(3-hydroxypropyl)aminopentyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1′-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1669)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1′-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1670)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1671)    (S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1672)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1673)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1674) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group-   1675)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]7-hydroxybicyclo[3.3.0]-2-octene-   1676)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1677) (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,4R,    E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1678)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1679)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1680)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1681)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1682)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1683)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1684) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group-   1685)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1686)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1687)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1688)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1689)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1690)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl]-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1691)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1692)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicylo[3.3.0]-2-octene-   1693)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1694) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group-   1695)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1696)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1697)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1698)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1699)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1700)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1701)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1702)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1703)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1704) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group-   1705)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1706)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1707)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1708)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1709)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1710)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1711)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1712)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1713)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1714) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group-   1715)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1716)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1717)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1718)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1719)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1720)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1721)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1722)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1723)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3R,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1724) compounds of compound numbers-1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group-   1725)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1726)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1727)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1728)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1729)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1730)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1731)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1732)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1733)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3R,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1734) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group-   1735)    (1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1736)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1737)    (1S,5S,6R,7R)-3-(5-N,N-diethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1738)    (1S,5S,6R,7R)-3-[5-N-(3-hydroxypropyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1739)    (1S,5S,6R,7R)-3-[5-N-(4-pyridylmethyl)aminopentyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1740)    (1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1741)    (1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1742)    (1S,5S,6R,7R)-3-(5-piperidinopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1743)    (1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1744) compounds of compound numbers 1114 to 1194 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group at position 6 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by the    (3R,1E)-3-hydroxy-1-octenyl group-   1745)    (1S,5S,6R,7S)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1746)    (1S,5S,6R,7S)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1747)    (1R,5R,6S,7S)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1748)    (1R,5R,6S,7S)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1749)    (1R,5R,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1750)    (1R,5R,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1751)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-hydroxy-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1752)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1753)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1754)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1755)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1756)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1757)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-hexenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1758)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1759)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-heptenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1760)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1761)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1762)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1763)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-1-decenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1764)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1765)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1766)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1767)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1768)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1769)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3(3-ethylcyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1770)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3(3-ethylcyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1771)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1772)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-cyclopentyl-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1773) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,    1E)-3-hydroxy-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1774) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,    1E)-3-hydroxy-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1775)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1776) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,    1E)-3-hydroxy-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1777)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1778)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1779)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1780)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1781)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1782)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1783)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1784)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1785)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1786) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,    1E)-3-hydroxy-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1787)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1788)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1789)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(p-tolyl)-1    butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1790)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopenty)-6-[(3S,1E)-3-hydroxy-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1791)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl-6-[(3R,1E)-3-hydroxy-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1792)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1793)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1794)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1795)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-5-(β-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1796)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1797)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1798)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(4-methoxyphenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1799)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(4-N,N-dimethylaminophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1800)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(3-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1801)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(3-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1802)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(4-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1803)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(4-chlorophenyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1804)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1805)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1806)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1807)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-3-phenyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1808)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1809)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1810)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1811)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1812)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-3(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1813)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-3(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1814)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1815)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1816)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-3-methyl-5(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1817)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-3-methyl-5(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1818)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4,4-dimethyl-loctenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1819)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4,4-dimethyl-loctenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1820)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E,5Z)-3-hydroxy-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1821)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E,5Z)-3-hydroxy-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1822)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-6-octyn-1-enyl]7-hydroxybicyclo[3.3.0]-2-octene-   1823)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1824)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1825)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1826) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,    E)-3-hydroxy-4,4-dimethyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1827)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4,4-dimethyl-6-octyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1828)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,4S,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1829)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,1E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1830) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4S,    E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1831) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,4R,    E)-3-hydroxy-4-methyl-6-nonyn-1-enyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1832)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-phenoxy-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1833)    (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-1-octynyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1834)    (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-1-octynyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1835) (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,    1Z)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1836)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1Z)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1837)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxyoctyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1838)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxyoctyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1839)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-3-methyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1840)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-3-methyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1841)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-4,4-dimethyloctyl-7-hydroxybicyclo[3.3.0]-2-octene-   1842)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-4,4-dimethyloctyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1843)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-3-phenylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1844)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-3-phenylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1845)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-4-phenylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1846)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-4-phenylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1847)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-4-(m-tolyl)butyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1848)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-4-(m-tolyl)butyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1849)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S)-3-hydroxy-3-cyclopentylpropyl]7-hydroxybicyclo[3.3.0]-2-octene-   1850)    (1S,5S,6%,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R)-3-hydroxy-3-cyclopentylpropyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1851)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1852)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1853)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-hydroxy-4-butyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1854)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-butyl-1,5-hexadienyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1855)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-butyl-1,5-hexadienyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1856)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-cyclopentyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1857)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-cyclopentyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1858)    (1S,5S,6R,7R)-3-(S—N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-cyclohexyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1859)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-cyclohexyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1860)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1861)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-4-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1862)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-(1-hydroxycyclopentyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1863)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-(1-hydroxycyclohexyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1864)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1865)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-4-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1866)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1867)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-1,3-octadienyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1868)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,8S)-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1869)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,9R)-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1870)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E,5S)-5-methyl-1,3-nonadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1871)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E,5R)-5-methyl-1,3-nonadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1872)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,4R)-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1873)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,4S)-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1874)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-methyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1875)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,4R)-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1876)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,4S)-4-ethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1877)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-ethyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1878)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-butyl-1,3-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1879)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,5Z)-1,5-octadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1880)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E,5Z)-1,3,5-octatrienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1881)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-cyclopentyliden-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1882)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-cyclohexyliden-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1883)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-2-phenylvinyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1884)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-2-(o-tolyl)vinyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1885)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-2-(m-tolyl)vinyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1886)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-2-(p-tolyl)vinyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1887)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-phenyl-1-propenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1888)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-phenyl-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene.-   1889)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-phenyl-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1890)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-phenyl-3-methyl-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1891)    (1S,5S,6R,7%)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-(o-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1892)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1893)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4-(p-tolyl)-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1894)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-4-(m-tolyl)-1,3-butadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1895)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1896)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-5-(m-tolyl)-1,3-pentadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1897)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-4,4-bisphenylsulfonyl-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1898)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E,3E)-5-(m-tolyl)-1,3-hexadienyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1899)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(4-phenoxybutyl)-7-hydroxy    bicyclo[3.3.0]-2-octene-   1900)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-propenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1901)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-butenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1902)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-pentenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1903)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-hexenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1904)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-heptenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1905)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-octenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1906)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-nonenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1907)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-1-decenyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1908)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-3-oxo-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1909)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4R,1E)-3-oxo-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1910)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4,4-dimethyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1911)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(5S,1E)-3-oxo-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1912)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(5R,1E)-3-oxo-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1913)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-cyclopentyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1914)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-cyclohexyl-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1915)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-cyclopentyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1916)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-cyclohexyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1917)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-phenyl-S-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1918)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-phenyl-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1919)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-5-phenyl-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1920)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-(o-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1921)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-(m-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1922)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-3-(p-tolyl)-1-propenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1923)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-(o-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1924)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1925)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-4-(p-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1926)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-5-(o-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1927)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-5-(m-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1928)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1E)-3-oxo-5-(p-tolyl)-1-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1929)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-hydroxymethyl-7-hydroxy    bicyclo[3.3.0]-2-octene-   1930)    (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxyethyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1931)    (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxyethyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1932)    (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxypentyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1933)    (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxypentyl]-7-hydroxy    bicyclo[3.3.0]-2-octene-   1934)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxy-1-methylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1935)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxy-1-methylbutyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1936)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R,2E)-1-hydroxy-2-nonenyl]-7-    hydroxybicyclo[3.3.0]-2-octene-   1937)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S,2E)-1-hydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1938)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R,3S,2E)-1,3-dihydroxy-2-nonenyl]-7-hydroxybicyclo    [3.3.0]-2-octene-   1939)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S,3S,2E)-1,3-dihydroxy-2-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1940)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R,3S,2E)-1,3-dihydroxy-4-cyclopentyl-2-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1941)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S,3S,2E)-1,3-dihydroxy-4-cyclopentyl-2-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1942)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R,3S,2E)-1,3-dihydroxy-5-phenyl-2-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1943)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S,3S,2E)-1,3-dihydroxy-5-phenyl-2-pentenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1944)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxy-2-pentynyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1945)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxy-2-pentynyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1946)    (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1R)-1-hydroxy-5-phenoxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1947)    (1S,5S,6S,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(1S)-1-hydroxy-5-phenoxypentyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1948)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxyphenylmethyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1949)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxyphenylmethyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1950)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(o-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1951)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(o-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1952)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(m-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1953)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(m-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1954)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(p-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1955)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(p-tolyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1956)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(4-methoxyphenyl)    methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1957)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(4-methoxyphenyl)    methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1958)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(4-N,N-dimethylamino    phenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1959)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(4-N,N-dimethylamino    phenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1960)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(R)-hydroxy(3-chlorophenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1961)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(S)-hydroxy(3-chlorophenyl)methyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1962)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-formyl-7-hydroxybicyclo[3.3.0]-2-octene-   1963)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-acetyl-7-hydroxybicyclo[3.3.0]-2-octene-   1964)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopenty)-6-benzoyl-7-hydroxybicyclo[3.3.0]-2-octene-   1965)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(o-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene-   1966)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(m-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene-   1967)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(p-tolyl)-7-hydroxybicyclo[3.3.0]-2-octene-   1968)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminophenyl)-6-(4-methoxyphenylcarbonyl)-7-hydroxy    bicyclo [3.3.0]-2-octene-   1969)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(4-N,N-dimethylaminophenyl    carbonyl)-7-hydroxybicyclo[3.3.0]-2-octene-   1970)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-(3-chlorophenylcarbonyl)-7-hydroxy    bicyclo[3.3.0]-2-octene-   1971)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-phenylvinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1972)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(4-methoxyphenyl)vinyl    carbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1973)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(4-N,N-dimethylaminophenyl)    vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1974)    (1,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(3-chlorophenyl)vinyl    carbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1975)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2(2-thienyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1976)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(2E)-2-(4-pyridyl)vinylcarbonyl]-7-hydroxybicyclo[3.3.0]-2-octene-   1977) compounds of compound numbers 1655 to 1976 of the examples    given above, wherein the 5-N,N-dimethylaminopentyl group, which is a    substitution group at position 3 in the structure of the    bicyclo[3.3.0]-2-octene cycle, has been replaced by either of the    5-aminopentyl group, the 5-N,N-diethylaminopentyl group, the    5-N-(3-hydroxypropyl)aminopentyl group, the    5-N-(4-pyridylmethyl)aminopentyl group, the    5-N,N-diisopropylaminopentyl group, the 5-(1-pyrrolidinyl)pentyl    group or the 5-piperidinopentyl group, the 5-morpholinopentyl group-   1978)    (1S,2R,3R,5S)-7-[(E)-5-aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxy    bicyclo[3.3.0]octane-   1979)    (1S,2R,3R,5S)-7-[(E)-5-N-methylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1980)    (1S,2R,3R,5S)-7-[(E)-5-N-ethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]    octane-   1981) (1S,2R,3R,5S)-7-[(E)-5-N-propylaminopentylidene]-2-[(3S,    1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1982)    (1S,2R,3R,5S)-7-[(E)-5-N-isopropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1983)    (1S,2R,3R,5S)-7-[(E)-5-N-butylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1984)    (1S,2R,3R,5S)-7-[(E)-5-N-t-butylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1985)    (1S,2R,3R,5S)-7-[(E)-5-N-phenylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1986)    (1S,2R,3R,5S)-7-[(E)-5-N-benzylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1987)    (1S,2R,3R,5S)-7-[(E)-5-N-(4-pyridylmethyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1988)    (1S,2R,3R,5S)-7-[(E)-5-(1-pyrrolidinyl)pentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1989)    (1S,2R,3R,5S)-7-[(E)-5-piperidinopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1990)    (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1991)    (1S,2R,3R,5S)-7-[(E)-5-(4-N-methyl-1-piperazinyl)pentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1992)    (1S,2R,3R,5S)-7-[(E)-5-N-(2-pyridyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1993)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-loctenyl]-3-hydroxybicyclo[3.3.0]octane-   1994)    (1S,2R,3R,5S)-7-[(E)-5-N,N-diethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1995)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dipropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-loctenyl]-3-hydroxybicyclo[3.3.0]octane-   1996)    (1S,2R,3R,5S)-7-[(E)-5-N,N-diisopropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1997)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dibutylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1998)    (1S,2R,3R,5S)-7-[(E)-5-N-t-butyl-N-methylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   1999)    (1S,2R,3R,5S)-7-[(E)-5-N-(2-hydroxyethyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2000)    (1S,2R,3R,5S)-7-[(E)-5-N-(3-hydroxypropyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2001) (1S,2R,3R,5S)-7-[(E)-4-aminobutylidene]-2-[(3S,1    E)-3-hydroxy-1-octenyl]-3-hydroxy bicyclo[3.3.0]octane-   2002)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylaminobutylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2003)    (1S,2R,3R,5S)-7-[(E)-6-aminohexylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxy    bicyclo[3.3.0]octane-   2004) (1S,2R,3R,5S)-7-[(E)-6-N,N-dimethylaminohexylidene]-2-[(3S,    1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2005)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-diisopropylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2006)    (1S,2R,3R,5S)-7-[(E)-2-(2-N-t-butyl-N-methylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2007)    (1S,2R,3R,5S)-7-[(E)-2-[2-(1-pyrrolidinyl)ethyl]oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2008)    (1S,2R,3R,5S)-7-[(E)-2-(2-piperidinoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2009)    (1S,2R,3R,5S)-7-[(E)-2-(2-morpholinoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]    octane-   2010)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)thioethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2011)    (1S,2R,3R,5S)-7-[(E)-2-N-(2-N,N-dimethylaminoethyl)aminoethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2012)    (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)oxymethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2013)    (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)thiomethylene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2014)    (1S,2R,3R,5S)-7-[(E)-N-(2-N,N-dimethylaminoethyl)aminomethylene]E-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2015)    (1S,2R,3R,5S)-7-[(E)-5-aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2016)    (1S,2R,3R,5S)-7-[(E)-5-N-methylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2017)    (1S,2R,3R,5S)-7-[(E)-5-N-ethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl]-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2018)    (1S,2R,3R,5S)-7-[(E)-5-N-propylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2019)    (1S,2R,3R,5S)-7-[(E)-5-N-isopropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo    [3.3.0]octane-   2020) (1S,2R,3R,5S)-7-[(E)-5-N-butylaminopentylidene]-2-[(3S,    E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2021)    (1S,2R,3R,5S)-7-[(E)-5-N-t-butylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2022)    (1S,2R,3R,5S)-7-[(E)-5-N-phenylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2023)    (1S,2R,3R,5S)-7-[(E)-5-N-benzylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2024)    (1S,2R,3R,5S)-7-[(E)-5-N-(4-pyridylmethyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2025)    (1S,2R,3R,5S)-7-[(E)-5-(1-pyrrolidinyl)pentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2026)    (1S,2R,3R,5S)-7-[(E)-5-piperidinopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2027)    (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2028)    (1S,2R,3R,5S)-7-[(E)-5-(4-N-methyl-1-piperazinyl)pentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2029)    (1S,2R,3R,5S)-7-[(E)-5-N-(2-pyridyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]    octane-   2030)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2031)    (1S,2R,3R,5S)-7-[(E)-5-N,N-diethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2032)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dipropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2033)    (1S,2R,3R,5S)-7-[(E)-5-N,N-diisopropylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2034)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dibutylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2035)    (1S,2R,3R,5S)-7-[(E)-5-N-t-butyl-N-methylaminopentylidene]-2-[(3S,1E)-3-hydroxy-3-    cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2036)    (1S,2R,3R,5S)-7-[(E)-5-N-(2-hydroxyethyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2037)    (1S,2R,3R,5S)-7-[(E)-5-N-(3-hydroxypropyl)aminopentylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2038)    (1S,2R,3R,5S)-7-[(E)-4-aminobutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo    [3.3.0]octane-   2039)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylaminobutylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2040)    (1S,2R,3R,5S)-7-[(E)-6-aminohexylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1    propenyl]-3-hydroxybicyclo [3.3.0]octane-   2041)    (1S,2R,3R,5S)-7-[(E)-6-N,N-dimethylaminohexylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2042)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2043)    (1,2R,3R,5S)-7-[(E)-2-(2-N,N-diisopropylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2044)    (1S,2R,3R,5S)-7-[(E)-2-(2-N-t-butyl-N-methylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2045)    (1S,2R,3R,5S)-7-[(E)-2-[2-(1-pyrrolidinyl)ethyl]oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2046)    (1S,2R,3R,5S)-7-[(E)-2-(2-piperidinoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2047)    (1S,2R¹³R,5S)-7-[(E)-2-(2-morpholinoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2048)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)thioethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2049)    (1S,2R,3R,5S)-7-[(E)-2-N-(2-N,N-dimethylaminoethyl)aminoethylidene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2050)    (S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)oxymethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2051)    (1S,2R¹³R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)thiomethylene]-2-[(3S,    1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2052)    (1S,2R,3R,5S)-7-[(E)-N-(2-N,N-dimethylaminoethyl)aminomethylene]-2-[(3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl]-3-hydroxybicyclo[3.3.0]octane-   2053)    (1S,2R,3R,5S)-7-[(E)-5-aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]    octane-   2054)    (1S,2R,3R,5S)-7-[(E)-5-N-methylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2055) (1S,2R,3R,5S)-7-[(E)-5-N-ethylaminopentylidene]-2-[(3S,4S,    E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo [3.3.0]    octane-   2056)    (1S,2R,3R,5S)-7-[(E)-5-N-propylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2057)    (1S,2R¹³R,5S)-7-[(E)-5-N-isopropylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2058)    (1S,2R¹³R,5S)-7-[(E)-5-N-butylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl    6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]-octane-   2059)    (1S,2R,3R,5S)-7-[(E)-5-N-t-butylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2060)    (1S,2R,3R,5S)-7-[(E)-5-N-phenylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2061)    (1S,2R,3R,5S)-7-[(E)-5-N-benzylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2062)    (1S,2R,3R,5S)-7-[(E)-5-N-(4-pyridylmethyl)aminopentylidene]-2-[(3S,4S,0E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2063)    (1S,2R,3R,5S)-7-[(E)-5-(1-pyrrolidinyl)pentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2064)    (1S,2R,3R,5S)-7-[(E)-5-piperidinopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2065)    (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2066)    (1S,2R,3R,5S)-7-[(E)-5-(4-N-methyl-1-piperazinyl)pentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2067)    (1S,2R,3R,5S)-7-[(E)-5-N-(2-pyridyl)aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2068)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2069)    (1S,2R,3R,5S)-7-[(E)-5-N,N-diethylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2070)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dipropylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2071)    (1S,2R,3R,5S)-7-[(E)-5-N,N-diisopropylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2072)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dibutylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2073)    (1S,2R,3R,5S)-7-[(E)-5-N-t-butyl-N-methylaminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2074)    (1S,2R,3R,5S)-7-[(E)-5-N-(2-hydroxyethyl)aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2075)    (1S,2R,3R,5S)-7-[(E)-5-N-(3-hydroxypropyl)aminopentylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2076)    (1S,2R,3R,5S)-7-[(E)-4-aminobutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1    enyl]-3-hydroxybicyclo[3.3.0]octane-   2077)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylaminobutylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2078)    (1S,2R,3R,5S)-7-[(E)-6-aminohexylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2079)    (1S,2R,3R,5S)-7-[(E)-6-N,N-dimethylaminohexylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2080)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2081)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-diisopropylaminoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2082)    (1S,2R,3R,5S)-7-[(E)-2-(2-N-t-butyl-N-methylaminoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2083)    (1S,2R,3R,5S)-7-[(E)-2-[2-(1-pyrrolidinyl)ethyl]oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2084)    (1S,2R,3R,5S)-7-[(E)-2-(2-piperidinoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2085)    (1S,2R,3R,5S)-7-[(E)-2-(2-morpholinoethyl)oxyethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2086)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)thioethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2087)    (1S,2R,3R,5S)-7-[(E)-2-N-(2-N,N-dimethylaminoethyl)aminoethylidene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2088)    (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)oxymethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2089)    (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)thiomethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2090)    (1S,2R,3R,5S)-7-[(E)-N-(2-N,N-dimethylaminoethyl)aminomethylene]-2-[(3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2091)    (1S,2R,3R,5S)-7-[(E)-5-aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2092)    (1S,2R,3R,5S)-7-[(E)-5-N-methylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2093)    (1S,2R,3R,5S)-7-[(E)-5-N-ethylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2094)    (1S,2R,3R,5S)-7-[(E)-5-N-propylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2095)    (1S,2R,3R,5S)-7-[(E)-5-N-isopropylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2096)    (1S,2R,3R,5S)-7-[(E)-5-N-butylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2097)    (1S,2R,3R,5S)-7-[(E)-5-N-t-butylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2098)    (1S,2R,3R,5S)-7-[(E)-5-N-phenylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2099)    (1S,2R,3R,5S)-7-[(E)-5-N-benzylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2100)    (1S,2R,3R,5S)-7-[(E)-5-N-(4-pyridylmethyl)aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2101)    (1S,2R,3R,5S)-7-[(E)-5-(1-pyrrolidinyl)pentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2102)    (1S,2R,3R,5S)-7-[(E)-5-piperidinopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2103)    (1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2104)    (1S,2R,3R,5S)-7-[(E)-5-(4-N-methyl-1-piperazinyl)pentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane.-   2105)    (1S,2R,3R,5S)-7-[(E)-5-N-(2-pyridyl)aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2106)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2107)    (1S,2R,3R,5S)-7-[(E)-5-N,N-diethylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2108)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dipropylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2109)    (1S,2R,3R,5S)-7-[(E)-5-N,N-diisopropylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2110)    (1S,2R,3R,5S)-7-[(E)-5-N,N-dibutylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2111)    (1S,2R,3R,5S)-7-[(E)-5-N-t-butyl-N-methylaminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2112)    (1S,2R,3R,5S)-7-[(E)-5-N-(2-hydroxyethyl)aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2113)    (1S,2R,3R,5S)-7-[(E)-5-N-(3-hydroxypropyl)aminopentylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2114)    (1S,2R,3R,5S)-7-[(E)-4-aminobutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2115)    (1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylaminobutylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2116)    (1S,2R,3R,5S)-7-[(E)-6-aminohexylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2117)    (1S,2R,3R,5S)-7-[(E)-6-N,N-dimethylaminohexylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2118)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2119)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-diisopropylaminoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2120)    (1S,2R,3R,5S)-7-[(E)-2-(2-N-t-butyl-N-methylaminoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2121) (1    S,2R,3R,5S)-7-[(E)-2-[2-(1-pyrrolidinyl)ethyl]oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2122)    (1S,2R,3R,5S)-7-[(E)-2-(2-piperidinoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2123)    (1S,2R,3R,5S)-7-[(E)-2-(2-morpholinoethyl)oxyethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2124)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)thioethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2125)    (1S,2R,3R,5S)-7-[(E)-2-N-(2-N,N-dimethylaminoethyl)aminoethylidene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2126)    (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)oxymethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2127)    (1S,2R,3R,5S)-7-[(E)-(2-N,N-dimethylaminoethyl)thiomethylene]-2-[(3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2128)    (1S,2R,3R,5S)-7-[(E)-N-(2-N,N-dimethylaminoethyl)aminomethylene]-2-[(3S,4R,1E)3-hydroxy-4-methyl-6-octyn-1-enyl]-3-hydroxybicyclo[3.3.0]octane-   2129) compounds of compound numbers 1978 to 2014 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group bonded to the carbon at position 12 of the    prostacyclin carbon identification number, has been replaced by    either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (E)-4-(m-tolyl)-1-butenyl group, the    (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the    (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the    (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group or the    (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group, the    2-(1-hydroxycyclohexyl)ethynyl group-   2130)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-aminobutyl)-1H-cyclopenta    [b]benzofuran-   2131)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran-   2132)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N-ethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2133)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N-propylaminobutyl)-1H-cyclopenta[b]benzofuran-   2134)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N-isopropylaminobutyl)-1H-cyclopenta[b]benzofuran-   2135)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N-butylaminobutyl)-1H-cyclopenta[b]benzofuran-   2136)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-(4-N-t-butylaminobutyl)-1H-cyclopenta[b]benzofuran-   2137)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N-phenylaminobutyl)-1H-cyclopenta[b]benzofuran-   2138)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N-benzylaminobutyl)-1H-cyclopenta[b]benzofuran-   2139)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-N-(4-pyridylmethyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2140)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5[4-(1-pyrrolidinyl)butyl]-1H-cyclopenta[b]benzofuran-   2141)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-piperidinobutyl)-1H-cyclopenta[b]benzofuran-   2142)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-morpholinobutyl)-1H-cyclopenta[b]benzofuran-   2143)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5[4-(4-N-methyl-1-piperazinyl)butyl]-1H-cyclopenta[b]benzofuran-   2144)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-N-(2-pyridyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2145)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2146)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N,N-diethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2147)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N,N-dipropylaminobutyl)-1H-cyclopenta[b]benzofuran-   2148)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N,N-diisopropylaminobutyl)-1H-cyclopenta[b]benzofuran-   2149)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N,N-dibutylaminobutyl)-1H-cyclopenta[b]benzofuran-   2150)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(4-N-t-butyl-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran-   2151)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-N-(2-hydroxyethyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2152) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydro    y-1-[(3S,1E)-3-hydroxy-1-octenyl]-5-[4-N-(3-hydroxypropyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2153)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-aminopropyl)-1H-cyclopenta[b]benzofuran-   2154)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N,N-dimethylaminopropyl)-1H-cyclopenta[b]benzofuran-   2155)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(5-aminopentyl)-1H-cyclopenta[b]benzofuran-   2156)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(5-N,N-dimethylaminopentyl)-1H-cyclopenta[b]benzofuran-   2157)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-1-octenyl]-5(3-N,N-dimethylaminopropyloxy)-1H-cyclopenta[b]benzofuran-   2158)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-aminobutyl)-1H-cyclopenta[b]benzofuran-   2159)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran-   2160)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-ethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2161)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-propylaminobutyl)-1H-cyclopenta    [b]benzofuran-   2162)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-isopropylaminobutyl)-1H-cyclopenta[b]benzofuran-   2163)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-butylaminobutyl)-1H-cyclopenta[b]benzofuran-   2164)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-t-butylaminobutyl)-1H-cyclopenta[b]benzofuran-   2165)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-phenylaminobutyl)-1H-cyclopenta    [b]benzofuran-   2166)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-benzylaminobutyl)-1H-cyclopenta[b]    benzofuran-   2167)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(4-pyridylmethyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2168)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-(1-pyrrolidinyl)butyl]-1H-cyclopenta[b]benzofuran-   2169)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-piperidinobutyl)-1H-cyclopenta[b]benzofuran-   2170)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-morpholinobutyl)-1H-cyclopenta[b]benzofuran.-   2171)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-(4-N-methyl-1-piperazinyl)butyl]-1H-cyclopenta[b]benzofuran-   2172)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(2-pyridyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2173)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2174)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-diethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2175)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dipropylaminobutyl)-1H-cyclopenta[b]benzofuran-   2176)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-diisopropylaminobutyl)-1H-cyclopenta    [b]benzofuran-   2177)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dibutylaminobutyl)-1H-cyclopenta[b]benzofuran-   2178)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-t-butyl-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran-   2179)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(2-hydroxyethyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2180)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(3-hydroxypropyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2181)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-aminopropyl)-1H-cyclopenta[b]benzofuran-   2182)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylaminopropyl)-1H-cyclopenta    [b]benzofuran-   2183)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(5-aminopentyl)-1H-cyclopenta[b]benzofuran-   2184)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(5-N,N-dimethylaminopentyl)-1H-cyclopenta[b]benzofuran-   2185)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4R,1E)-3-hydroxy-4-methyl-1*    octen-6-ynyl]-5-(3-N,N-dimethylaminopropyloxy)-1H-cyclopenta[b]benzofuran-   2186) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,    1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-aminobutyl)-1H-cyclopenta[b]benzofuran-   2187)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran-   2188)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-ethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2189)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-propylaminobutyl)-1H-cyclopenta[b]benzofuran-   2190) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,    1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-isopropylaminobutyl)-1H-cyclopenta[b]benzofuran-   2191)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-butylaminobutyl)-1H-cyclopenta[b]benzofuran-   2192)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-t-butylaminobutyl)-1H-cyclopenta[b]benzofuran-   2193)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-phenylaminobutyl)-1H-cyclopenta[b]benzofuran-   2194) (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,    1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-benzylaminobutyl)-1H-cyclopenta[b]benzofuran-   2195)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(4-pyridylmethyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2196)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-(1-pyrrolidinyl)butyl]-1H-cyclopenta[b]benzofuran-   2197)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-piperidinobutyl)-1H-cyclopenta[b]benzofuran-   2198)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-morpholinobutyl)-1H-cyclopenta[b]benzofuran-   2199)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-(4-N-methyl-1-piperazinyl)butyl]-1H-cyclopenta[b]benzofuran-   2200)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(2-pyridyl)aminobutyl]-1H-cyclopenta    [b]benzofuran-   2201)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2202)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-diethylaminobutyl)-1H-cyclopenta[b]benzofuran-   2203)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N,N-dipropylaminobutyl)-1H-cyclopenta    [b]benzofuran-   2204)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1    N    octen-6-ynyl]-5-(4-N,N-diisopropylaminobutyl)-1H-cyclopenta[b]benzofuran-   2205)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1    octen-6-ynyl]-5-(4-N,N-dibutylaminobutyl)-1H-cyclopenta[b]benzofuran-   2206)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1′-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(4-N-t-butyl-N-methylaminobutyl)-1H-cyclopenta[b]benzofuran-   2207)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(2-hydroxyethyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2208)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-[4-N-(3-hydroxypropyl)aminobutyl]-1H-cyclopenta[b]benzofuran-   2209)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-aminopropyl)-1H-cyclopenta[b]benzofuran-   2210)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylaminopropyl)-1H-cyclopenta[b]benzofuran-   2211)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(5-aminopentyl)-11H-cyclopenta[b]benzofuran-   2212)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(5-N,N-dimethylaminopentyl)-1H-cyclopenta[b]benzofuran-   2213)    (1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,4S,1E)-3-hydroxy-4-methyl-1-octen-6-ynyl]-5-(3-N,N-dimethylaminopropyloxy)-1H-cyclopenta[b]benzofuran-   2214) compounds of compound numbers 2130 to 1256 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group bonded to the carbon at position 12 of the    prostacyclin carbon identification number, has been replaced by    either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (E)-4-(m-tolyl)-1-butenyl group, the    (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group, the    (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the    (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the    (3R,1E)-3-hydroxy-3-phenyl-1-propenyl group or the    (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl-   2215)    (1S,2R,3R,5S)-7-[(Z)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2216)    (1R,5S,7R,8R)-3-(5-N,N-dimethylaminopentyl)-8-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene-   2217) (1S,2R,3R,5S,7R)-7-(5-N,N-dimethylaminopentyl)-2-[(3S,    1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane-   2218) (1    S,2R,3R,5S,7R)-7-[2-(2-N,N-dimethylaminoethoxy)ethyl]-2-[(3R,5    S,1E)-3-hydroxy-5-methyl-1-nonenyl]-3-hydroxybicyclo[3.3.0]octane-   2219)    (1S,3S,5R,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-oxabicyclo[3.3.0]octane-   2220)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-oxabicyclo[3.3.0]-3-octen-   2221)    (1S,5R,6R,7R)-3-[(Z)-5-N,N-dimethylaminopentylidene]-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-4-oxo-2-oxabicyclo[3.3.0]octane-   2222)    (1S,3S,5R,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-thiabicyclo[3.3.0]octane-   2223)    (1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-azabicyclo[3.3.0]-2-octene-   2224)    (1S,3S,5R,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-1-octenyl]-7-hydroxy-2-azabicyclo[3.3.0]octane-   2225) compunds of compound numbers 2215 to 1224 of the examples    given above, wherein the (3S,1E)-3-hydroxy-1-octenyl group, which is    a substitution group bonded to the carbon at position 12 of the    prostacyclin carbon identification number, has been replaced by    either of the (3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (3S,5R,1E)-3-hydroxy-5-methyl-1-nonenyl group, the    (4S,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (4R,1E)-4-hydroxy-4-methyl-1-octenyl group, the    (3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl group, the    (E)-4-(m-tolyl)-1-butenyl group, the    (3S,4S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group, the    (3S,4R,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl group, the    (3S,1E)-3-hydroxy-3-cyclopentyl-1-propenyl group, the    (3S,1E)-3-hydroxy-3-cyclohexyl-1-propenyl group, the    (3S,1E)-3-hydroxy-4-cyclopentyl-1-butenyl group, the    (3R,1E)-3-hydroxy-3-phenyl-1-propenylgroup or the    (3R,1E)-3-hydroxy-4-phenoxy-1-butenyl group-   2226) compunds of compound numbers 1 to 174, 262 to 435, 523 to 532,    543 to 728, 855 to 1104, 1105 to 1284, 1375 to 1554, 1645 to 1654,    1665 to 1850 and 1977 to 2225 of the examples given above, wherein    the hydroxyl groups/group, which are/is bonded to the carbon at    position 11 and/or at position 15 of the prostacyclin carbon    identification number, has/have been substituted for either of the    acetoxy group, t-butyldimethylsilyloxy group, trimethylsilyloxy    group or the tetrahydropyran-2-yloxy group-   2227) compunds of compound numbers 175 to 261, 533 to 542, 729 to    743, 855, 1008, 1093, 1104, 1285 to 1374, 1655 to 1664, 1851 to    1865, 1977, 2129, 2214 and 2225 of the examples given above, wherein    the hydroxyl groups/group, which are/is bonded to the carbon at    position 11 and/or at position 16 of the prostacyclin carbon    identification number, has/have been substituted for either of the    acetoxy group, the t-butyldimethylsilyloxy group, the    trimethylsilyloxy group or the tetrahydropyran-2-yloxy group-   2228) compunds of compound numbers 436 to 522, 744 to 855, 1008,    1093, 1104, 1555 to 1644, 1866 to 1977, 2129, 2214 and 2225 of the    examples given above, wherein the hydroxyl group, which is bonded to    the carbon at position 11 of the prostacyclin carbon identification    number, has been substituted for either of the acetoxy group, the    t-butyldimethylsilyloxy group, the trimethylsilyloxy group or the    tetrahydropyran-2-yloxy group 2229)    (1S,2R,3R,5S)-7-[(E)-2-(2-N,N-dimethylaminoethyl)oxyethylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane.

The nitrogen-containing compound represented by the above Formula (1)has an activity for the remedy of neural damage. Therefore, thenitrogen-containing compound of the present invention can be used as anagent for the treatment of disorders due to neural damage, or and agentfor the treatment of lesion of nerves due to external injuries.

Among the nitrogen-containing compound represented by the above Formula(1) of the present invention, those having an amido group at theextremity of the α-chain of prostacyclin analog structure, in otherwords, those whose A⁴ in the above Formula (1) is a carbonyl group arederived from functional groups such as a carboxyl group, analkoxycarbonyl group or a cyano group, by the method described in pages137 through 173 of the “Fourth Edition of the Experimental ChemistryCourse” by the Chemical Society of Japan, Volume 220 (Maruzen Co.,Ltd.). In other words, the target amide can be obtained by inserting afunctional group such as a carboxyl group, an alkoxycarbonyl group or acyano group at the site corresponding to the α-chain of the syntheticintermediate having the prostacyclin analog structure indicated by G inthe above Formula (1), and by adding the appropriate chemicalmodification. For example, as indicated in Scheme 1 below,

by converting the carboxyl group at position 1 of an isocarbacyclin intoan imidazolylcarbonyl group using 1,1′-carbonyldiimidazole, thenreacting with an amine to convert into an amide group, the target amidecan be obtained. Usually, the reaction uses polar aprotic solvents suchas dimethylformamide, N-methylpyrrolidone, hexamethyl phosphorictriamide, dimethyl sulfoxide. However, dimethylformamide andN-methylpyrrolidone are used preferably. The reaction is performed at atemperature range of 0 to 100° C. with a timeframe of 10 minutes to 24hours. However, it is performed preferably at a temperature range of 10to 60° C. with a timeframe of 15 minutes to 18 hours.

Among the nitrogen-containing compound represented by the above Formula(1) of the present invention, those having an amino group at theextremity of the α-chain of prostacyclin analog structure, in otherwords, those whose A⁴ in the above Formula (1) represents a single bond,or an aliphatic hydrocarbon group having 1 to 3 carbon atoms, arederived from functional groups such as an amide group, an imino group, ahalogen group, a carbonyl group, a cyano group or an azide group by themethod described in pages 279 through 317 of the “Fourth Edition of theExperimental Chemistry Course” by the Chemical Society of Japan, Volume20 (Maruzen Co., Ltd.). In other words, the target amines can beobtained by inserting a functional group such as an amide group, animino group, a halogen group, a carbonyl group, a cyano group or anazide group at the site corresponding to the α-chain of the syntheticintermediate having the prostacyclin analog structure indicated by G inthe above Formula (1), and by adding an adequate chemical modification.For example, as indicated in Scheme 2 below,

from an amide obtained using a method, for example, indicated in Scheme1, the target amine can be obtained with reducing agents such as lithiumaluminium hydride or borane. Usually, the reaction uses ether solventssuch as tetrahydrofurane, dioxane, dimethoxyethane, and preferably usestetrehydrofurane. The reaction is performed at a temperature range of 0to 100° C. and with a timeframe of 10 minutes to 24 hours. However, itis performed preferably at a temperature range of 10 to 60° C. with atimeframe of 15 minutes to 18 hours.

In addition, modifications at sites on the cyclic structure and at siteson the ω-chain of the nitrogen-containing compound represented by theabove Formula (1) of the present invention can be achieved followingroutes indicated for example in Scheme 3, Scheme 4 and Scheme 5, but arenot limited to the these.

[In the above, R⁴⁵, R⁵⁵, R⁶⁵ in Scheme 3, Scheme 4 and Scheme 5 arefunctional groups chosen among those exemplified by R⁴, R⁵, R⁶,respectively.]

The nitrogen-containing compound of the present invention is produced bycombining the modifications of the sites on the α-chain, the sites onthe cyclic structure and the site on the ω-chain.

Since the nitrogen-containing compound of the present invention has anactivity for the remedy of nerve damage, it can be used as an agent forthe treatment of disorders caused by nerve damage, or for the treatmentof lesions of the nerves due to external injuries. There are noparticular limitations on the scope of application of such an agent fortreating neural damage or lesion of nerves due to external injuries. Thedrug agent of the present invention is particularly useful for mammals,and can be suitably used for livestock, laboratory animals, pets andhumans, among others.

The agent for the treatment of disorders caused by nerve damage, or forthe treatment of lesions of the nerves due to external injuries of thepresent invention, can be used for the treatment of animal or humandisorders or lesions. There are no particular limitations on the scopeof disorders, which must be caused by a neural damage. The following canbe cited as concrete examples,

-   1) Neuro-degenerative disorders such as Alzheimer's disease, Pick's    disease, Lewy body disease, Parkinson's disease, Huntington's    chorea, spinocerebellar degeneration and amyotrophic lateral    sclerosis,-   2) demyelinating disorders such as acute disseminated    encephalomyelitis and multiple sclerosis,-   3) metabolic disorders such as brain lipidosis and Wilson's Disease,-   4) infectious disorders such as meningitis and Creutzfeld-Jacob    disease,-   5) peripheral neural damage such as polyneuritis and Guillain-Barre    Syndrome,-   6) cerebrovascular disorders such as cerebral infarction and    transient ischemia,-   7) nervous disorders (neuropathies) associated with diabetes and    renal diseases and-   8) brain tumors.    However, it is preferably used in disorders cited from 1) through    5).

No particular restriction exists on the method of administration.However, oral administration, percutaneous administration, nasaladministration, intravenous injection, intraperitoneal administration,rectal administration or intracerebroventricular administration arepreferred.

For the clinical application of the nitrogen-containing compound or thesalts thereof of the present invention, or clathrate compounds, it isdesirable to produce a pharmaceutical preparation formed by thenitrogen-containing compound and a pharmaceutically accepted solid orliquid carrier, and to further add diluents, in other words additivessuch as excipients and stabilizers, as necessary. The amine injectablepreparation of the present invention to be used for therapeuticadministration must be sterile. Sterilization can be easily achieved byfiltration through a sterilization filter membrane such as a membranefilter having a pore diameter of 0.2 μm.

In such pharmaceutical composition, the proportion of theabove-mentioned active ingredient with respect to the constituents ofthe carrier can be modulated, for example, between 0.000001 and 90% W/W.Therapeutic effective dose depends on the method of administration, age,and the disorder considered, however, 0.01% g to 1000 mg/day/individualis possible, and 0.01 μg to 10 mg/day/individual is preferred. For eachadministration route, it is desirable to determine the efficacy ofabsorption into the body for each compound, separately.

Concerning the formulation and the administration form, oraladministration is possible by making formulations such as granules,subtle granules, powders, pills, tablets, capsules or liquids, or,parenteral administration is possible by making agents for localapplications such as suppositories, aerosols, or ointments and skinpatches. As injectable agents, intravenous administration,intra-arterial administration, intramuscular administration,subcutaneous administration are possible. In addition, prior to use,powders for injectable solution can be prepared. In addition, nasaladministration, intraperitoneal administration, rectal administration orintracerebroventricular administration are possible.

Organic or inorganic, solid or liquid carriers or diluents can also beused to prepare the nitrogen-containing compound of the currentinvention to serve as a pharmaceutical preparation suited for oral,enteral or parenteral administration.

Binding agents such as acacia, corn starch, or gelatin, excipients suchas microcrystalline cellulose, disintegrants such as cornstarch andalginic acid, lubricants such as magnesium stearate, and sweeteners suchas saccharose and lactose can be cited as representative carriers ordiluents entering in the composition of tablets and capsules. If theformulation is a capsule, in addition to the above substances, liquidcarriers such as lipid oils may be included. Various sorts of othersubstances may be used as coating agents or agents for improving thephysical state of the dose units. Sterile compositions for injection,may be formulated according to a pharmaceutical method of the art. Forexample, it is desirable to dissolve or suspend the active compound inan excipient such as water or natural vegetal oil or synthetic lipidexcipient such as ethyl oleate. It is also possible to include bufferssuch as citrate, acetate, phosphate, and antioxydants such as ascorbate,according to accepted pharmaceutical methods.

The tablet form can be obtained by the usual method, for example it canbe made by using excipients such as lactose, starch or crystallinecellulose; binding agents such as carboxymethyl cellulose, methylcellulose or polyvinyl pyrrolidone; disintegrants such as sodiumalginate, sodium bicarbonate and sodium lauryl sulfate.

Likewise, pills, powders, granules can be made by the usual method usingthe above-mentioned excipients. Liquid agents and suspensions can bemade by the usual method using, for example, glycerin esters such astricaprilyn or triacetin, or alcohols such as ethanol. Capsules can beobtained by filling capsules, for instance, made of gelatin withgranules, powders, or liquids.

As a formulation for oral administration, the nitrogen-containingcompound of the present invention, can be converted into a cyclodextrinclathrate compound. The clathrate can be prepared by adding a solutionmade by dissolving cyclodextrin in water and/or an organic solventcapable of mixing easily with water, to a solution made by dissolvingthe nitrogen-containing compound in an organic solvent capable of mixingeasily with water. The mixture is heated, then vacuum concentrated underrefrigeration, filtered or decanted to separate the product and isolatethe target cyclodextrin clathrate compound. The proportion of organicsolvent and water varies with the solubility of the starting materialand of the product. It is desirable that the temperature when preparingcyclodextrin clathrate compound does not exceed 70° C. α-cyclodextrin,β-cyclodextrin, γ-cyclodextrin or any combination of the above, can beused for the preparation of cyclodextrin clathrate compound. Thestability of the nitrogen-containing compound can be increased by aconversion into a cyclodextrin clathrate compound.

As formulation for subcutaneous, intramuscular and intravenousadministration, injectable agents exist in the form of aqueous andnon-aqueous solutions. For example, physiological saline can be used foraqueous solutions. For non-aqueous solution, for example,propyleneglycol, polyethylene glycol, olive oil, ethyl oleate can beused, and anticeptic agents and stabilizers can be added to the above,as needed. Injectable agents are sterilized by suitably performingtreatments such as filtration through bacterial retention filters ormixing with bactericides.

As formulations for percutaneous administration, ointments and creamscan be cited as examples. Ointments can be made by the usual method withfats such as castor oil and olive oil, and emulsifiers such asdiethyleneglycol, sorbitan monofatty acid ester; creams can be madeusing vaseline with grease oil and emulsifiers such as diethyleneglycol,sorbitan monofatty acid ester.

For rectal administration, a usual suppository such as a gelatin softcapsule may be used.

Preparations for parenteral administration can be administered asemulsions. In other words, water is added to a homogenous solution madeof vegetal oils such as soybean oil, phospholipids such as lecithins andthe nitrogen-containing compound of the present invention, andhomogenized by homogenizers such as, for example, pressure injectionhomogenizer or ultrasonic homogenizer, to give lipid emulsion which canalso be used as an injectable agent.

EMBODIMENTS

In the following, the present invention will be explained moreconcretely by giving examples and reference examples. However, thepresent invention is not limited to these examples and referenceexamples.

REFERENCE EXAMPLE 1 Preparation of(1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

73 mg of(1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octenewas taken and dissolved in 2 mL of dimethylformamide. After addition of49 mg of 1,1′-carbonyldiimidazole, it was stirred at 50° C. for 1 hour.It was then cooled to ambient temperature, 5 mL of 25% ammoniumhydroxide in water was added, and stirred for 1 hour. An aqueoussolution saturated with potassium hydrogen sulfate was added andextracted with ethyl acetate. The organic layer was washed with anaqueous solution saturated with sodium bicarbonate, then with asaturated saline solution, and dried with anhydrous sodium sulfate.After filtration and concentration, it was subjected to a silicagelcolumn chromatography, to obtain 29 mg of the compound presented in thetitle (40% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.91 (brt, 3H, J=7.1 Hz), 1.17 (s, 3H),1.2–1.7 (m, 15H), 1.8–2.5 (m, 11H), 2.9–3.1 (m, 1H), 3.7–3.9 (m, 1H),5.30 (brs, 1H), 5.3–5.5 (m, 1H), 5.5–5.7 (m, 1H).

REFERENCE EXAMPLE 2

The compound shown in Table 1 was obtained with a method identical toReference example 1.

TABLE 1 Ref. Ex. NMR data No. starting material product Yield % δ 2(1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(4- 36 0.7–1.0(m, 3H), 1.0–2.5carboxybutyl)-6- carbamoylbutyl)-6- (m, 24H), 2.9–3.1(m,[(3S,1E)-3-hydroxy- [(3S,1E)-3-hydroxy- 1H), 3.7–3.9(m, 1H),1-octenyl]-7- 1-octenyl]-7- 4.0–4.2(m, 1H), 5.29(brs,hydroxybicyclo[3.3.0]- hydroxybicyclo[3.3.0]- 1H), 5.3–5.6(m, 2H),2-octene 2-octene 6.0–6.1(m, 1H), 6.6–6.9(m, 1H)

REFERENCE EXAMPLE 3 Preparation of(1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydrodroxybicyclo[3.3.0]-2-octene

59 mg of(1S,5S,6R,7R)-3-(4-methoxycarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octenewas taken and dissolved in 3 mL acetonitrile, under stirring, 10 mL of25% ammonium hydroxide in water was added and stirred for 6 days. Afterconcentration, it was subjected to a silicagel column chromatography, toobtain 34 mg of the compound presented in the title(60% yield).

1H-NMR (270 MHz, CDCl₃):δ0.88 (d, 3H, J=6.5 Hz), 0.7–1.0 (m, 3H),1.0–2.5 (m, 25H), 2.9–3.1 (m, 1H), 3.7–3.9 (q, 1H, J=8.9 Hz), 4.0–4.2(m, 1H), 5.29 (brs, 1H), 5.3–5.6 (m, 2H), 6.0–6.1 (m, 1H), 6.6–6.9 (m,1H).

REFERENCE EXAMPLE 4 Preparation of(1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

36 mg of(1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octenewas taken and dissolved in 1.5 mL of dimethylformamide. After additionof 32 mg of 1,1′-carbonyldiimidazole, it was stirred at 50° C. for 1hour. It was then cooled to ambient temperature, 25 mg of imidazole and33 mg of methylamine hydrochloride were added, and stirred at 50° C. for1.5 hours. An aqueous solution saturated with ammonium chloride wasadded and extracted with ethyl acetate. The organic layer was washedwith a saturated saline solution, and dried with anhydrous sodiumsulfate. After filtration and concentration, it was subjected to asilicagel column chromatography, to obtain 22 mg of the compoundpresented in the title (57% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.91 (brt, 3H, J=6.8 Hz), 1.16 (s, 3H),1.2–1.7 (m, 15H), 1.8–2.5 (m, 9H), 2.9–3.1 (m, 1H), 2.94 (s, 3H), 3.00(s, 3H), 3.7–3.9 (m, 1H), 5.30 (brs, 1H), 5.3–5.5 (m, 1H), 5.5–5.7 (m,1H).

REFERENCE EXAMPLES 5–8

The compounds shown in Table 2 were obtained with a method identical toReference example 4.

TABLE 2 Ref. Ex. NMR data No. starting material product Yield % δ 5(1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(4-N,N- 35 1.2–1.8(m, 6H), 2.33(s,carboxybutyl)-6- dimethylcarbamoylbutyl)- 3H), 1.9–2.5(m, 12H),[(3S,1E)-3-hydroxy-4- 6-[(3S,1E)-3-hydroxy- 2.7–3.1(m, 1H), 2.94(s,(m-tolyl)-1-butenyl]-7- 4-(m-tolyl)-1-butenyl]- 3H), 3.01(s, 3H),3.5–3.7 hydroxybicyclo[3.3.0]- 7-hydroxybicyclo[3.3.0]- (m, 1H),4.2–4.5(m, 1H), 2-octene 2-octene 5.27 (brs, 1H), 5.45–5.65 (m, 2H),6.9–7.1(m, 3H), 7.1–7.2(m, 1H) 6 (1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(4-78 1.2–1.75(m, 6H), 2.33(s, carboxybutyl)-6- N,N-dimethylcarbamoyl- 3H),1.75–2.5(m, 12H), [(3R,1E)-3-hydroxy-4- butyl)-6-[(3R,1E)-3- 2.94(s,3H), 3.00(s, 3H), (m-tolyl)-1-butenyl]-7- hydroxy-4-(m-tolyl)-1-2.9–3.1(m, 1H), 3.5–3.7 hydroxybicyclo[3.3.0]- butenyl]-7-hydroxy- (m,1H), 4.34, (q, 1H, 2-octene bicyclo[3 3.0]-2-octene J=6.2Hz), 5.27(brs,1H), 5.3–5.5(m, 1H), 5.5–5.7 (m, 1H), 6.9–7.1(m, 3H), 7.1–7.2(m, 1H) 7(1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(4- 60 1.2–2.1(m, 12H), 2.33(s,carboxybutyl)-6-[(E)- N,N-dimethylcarbamoyl- 3H), 2.1–2.5(m, 5H),4-(m-tolyl)-1-butenyl]- butyl)-6-[(E)-4- 2.5–2.8(m, 2H), 2.94(s,7-hydroxybicyclo- (m-tolyl)-1-butenyl]-7- 3H), 3.00(s, 3H), 2.9–3.1[3.3.0]-2-octene hydroxybicyclo[3.3.0]- (m, 1H), 3.5–3.7(m, 1H),2-octene 5.2–5.3(m, 2H), 5.4–5.6 (m, 1H), 6.9–7.1(m, 3H), 7.1–7.2(m, 1H)8 (1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(4- 35 1.2–1.9(m, 7H), 1.95–2.2carboxybutyl)-6- N,N-dimethylcarbamoyl- (m, 4H), 2.32(s, 3H),[4-(m-tolyl)-1,3- butyl)-6-[4-(m-tolyl)- 2.2–2.5(m, 4H), 2.95(s,butadienyl]-7-hydroxy 1,3-butadienyl]-7- 3H), 3.01(s, 3H), 2.9–3.1bicyclo[3.3.0]-2-octene hydroxybicyclo[3.3.0]- (m, 1H), 3.7–3.9(m, 1H),2-octene 5.31(brs, 1H), 5.65–5.8 (m, 1H), 6.15–6.55(m, 2H), 6.65–6.8(m,1H), 6.95–7.1(m, 1H), 7.1–7.3 (m, 3H)

REFERENCE EXAMPLE 9 Preparation of(1S,5S,6R,7R)-3-[4-N-(2-ethoxycarbonylethyl)carbamoylbutyl]-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

36 mg of(1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octenewas taken and dissolved in 1 mL of dimethylformamide. After addition of24 mg of 1,1′-carbonyldiimidazole, it was stirred for 20 hours. 14 mg ofimidazole and 31 mg of ethyl 3-aminopropionate were added and stirredfor 8 hours. An aqueous solution saturated with ammonium chloride wasadded and extracted with ethyl acetate. The organic layer was washedwith a saturated saline solution, and dried with anhydrous sodiumsulfate. After filtration and concentration, it was subjected tosilicagel column chromatography, to obtain 36 mg of the compoundpresented in the title (79% yield).

1H-NMR (270 MHz, CDCl₃):δ0.91 (brt, 3H, J=6.1 Hz), 1.16 (s, 3H), 1.27(t, 3H, J=7.2 Hz), 1.2–1.7 (m, 13H), 2.53 (t, 2H, J=5.9 Hz), 1.8–2.6 (m,11H), 2.9–3.1 (m, 1H), 3.51 (q, 2H, J=5.8 Hz), 3.77 (q, 1H, J=7.0 Hz),4.15 (q, 2H, J=7.1 Hz), 5.28 (brs, 1H), 5.3–5.5 (m, 1H), 5.5–5.7 (m,1H), 6.0–6.2 (m, 1H).

REFERENCE EXAMPLE 10 Preparation of(1S,5S,6R,7R)-3-(4-piperidinocarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene

3 ml of toluene and 1 mL of 15% trimethylaluminium-hexane solution wereadded to a nitrogen exchanged flask. 148 μL of piperidine was added andstirred at ambient temperature for 3 hours. 59 mg of(1S,5S,6R,7R)-3-(4-methoxycarbonylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octenewas dissolved and added in 4 mL of toluene, and stirred at 60° C. for 18hours. An aqueous solution saturated with potassium hydrogen sulfate wasadded, extracted with ethyl acetate. The organic layer was washed withan aqueous solution saturated with sodium bicarbonate, and dried withanhydrous sodium sulfate. After filtration and concentration, it wassubjected to a silicagel column chromatography, to obtain 62 mg of thecompound presented in the title (93% yield).

1H-NMR (270 MHz, CDCl₃):δ0.8–0.95 (m, 3H), 0.90 (d, 3H, J=6.2 Hz),1.1–1.7 (m, 22H), 1.8–2.5 (m, 9H), 2.9–3.1 (m, 1H), 3.3–3.5 (m, 2H),3.5–3.6 (m, 2H), 3.77 (q, 1H, J=6.8 Hz), 4.1–4.25 (m, 1H), 5.29 (brs,1H), 5.45–5.6 (m, 2H).

REFERENCE EXAMPLES 11–13

The compounds shown in Table 3 were obtained with a method identical toReference example 10.

TABLE 3 Ref. starting material Ex. carboxylic acid NMR data No.derivatives amine product Yield % δ 11 (1S,5S,6R,7R)-3- diethylamine(1S,5S,6R,7R)-3- 42 0.7–1.0(m, 6H), 1.11(t, (4-methoxy- (4-N,N-diethyl-3H, J=7.0Hz), 1.17(t, 3H, carbonylbutyl)-6- carbamoylbutyl)-6- J=7.2Hz),1.0–1.8(m, [(3S,5S,1E)-3- [(3S,5S,1E)-3- 13H), 1.8–2.1(m, 4H),hydroxy-5-methyl- hydroxy-5-methyl-1- 2.1–2.5(m, 5H), 2.9–3.11-nonenyl]-7- nonenyl]-7-hydroxy- (m, 1H), 3.30(q, 2H, hydroxybicyclo-bicyclo[3.3.0]-2- J=7.2Hz), 3.37(q, 2H, [3.3.0]-2-octene octeneJ=7.1Hz), 3.7–3.8(m, 1H), 4.1–4.2(m, 1H), 5.29 (brs, 1H), 5.4–5.6(m, 2H)12 (1S,5S,6R,7R)-3- morpholine (1S,5S,6R,7R)-3-(4- 92 0.7–1.0(m, 6H),1.0–2.1 (4-methoxy morpholinocarbonyl- (m, 21H), 2.1–2.5(m,carbonylbutyl)-6- butyl)-6-[(3S,5S,1E)- 4H), 2.9–3.1(m, 1H),[(3S,5S,1E)-3- 3-hydroxy-5-methyl- 3.4–3.5(m, 2H), 3.5–3.7hydroxy-5-methyl- 1-nonenyl]-7-hydroxy (m, 6H), 3.7–3.8(m, 1H),1-nonenyl]-7- bicyclo[3.3.0]-2- 4.1–4.2(m, 1H), 5.29(brs,hydroxybicyclo- octene 1H), 5.4–5.6(m, 2H) [3.3.0]-2-octene 13(1S,5S,6R,7R)-3- 4-amino- (1S,5S,6R,7R)-3-[4- 71 0.7–1.0(m, 6H), 1.0–2.5(4-methoxy- methyl- N-(4-pyridylmethyl) (m, 25H), 2.9–3.1(m,carbonylbutyl)-6- pyridine carbamoylbutyl]-6- 1H), 3.7–3.85(m, 1H),[(3S,5S,1E)-3- [(3S,5S,1E)-3- 4.1–4.2(m, 1H)4.45(d, hydroxy-5-methyl-hydroxy-5-methyl- 2H, J=6.2Hz), 5.27(brs, 1-nonenyl]-7- 1-nonenyl]-7-1H), 5.4–5.6(m, 2H), hydroxybicyclo- hydroxybicyclo- 6.0–6.2(m, 1H),7.20(d, [3.3.0]-2-octene [3.3.0]-2-octene 2H, J=5.9Hz), 8.53(d, 2H,J=5.9Hz)

REFERENCE EXAMPLE 14 Preparation of(1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-(tetrahydropyran-2-yloxy)-bicyclo[3.3.0]-2-octene

40 mg of(1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-(tetrahydropyran-2-yloxy)-bicyclo[3.3.0]-2-octenewas dissolved in 4 mL of dimethylformamide, and 27 mg of1-hydroxybenzotriazole monohydrate was added. While stirring on ice, 71μL of diisopropylamine was added and stirred at 0° C. for 20 minutes. 38mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloridewas added, and stirred for 13 hours. An aqueous solution of ammoniumchloride was added and extracted with ethyl acetate. The organic layerwas washed with a saline solution, and dried with anhydrous sodiumsulfate. After filtration and concentration, it was subjected to asilicagel column chromatography, to obtain 29 mg of the compoundpresented in the title (56% yield).

1H-NMR (270 MHz, CDCl₃):δ 1.22 (d, 6H, J=5.0 Hz), 1.37 (d, 6H, J=5.0Hz), 1.1–1.8 (m, 13H), 2.34 (s, 3H), 1.8–2.7 (m, 11H), 2.9–3.1 (m, 1H),3.5–4.0 (m, 5H), 4.1–4.3 (m, 1H), 5.15–5.3 (m, 2H), 5.45–5.9 (m, 1H),6.9–7.05 (m, 3H), 7.1–7.25 (m, 1H).

REFERENCE EXAMPLE 15 Preparation of(1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane.

59 mg of(1S,2R,3R,5S)-7-[(E)-4-carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octanewas taken and was dissolved in 2 mL of dimethylformamide. 25 mg of1,1′-carbonyldiimidazole was added and, stirred at ambient temperaturefor 5 hours. 20 mg of imidazole and 23 mg of dimethylamine hydrochloridewere added, and stirred at ambient temperature for 18 hours. An aqueoussolution saturated with ammonium chloride was added and extracted withethyl acetate. The organic layer was washed with a saturated salinesolution, and dried with anhydrous sodium sulfate. After filtration andconcentration, it was subjected to a silicagel column chromatography, toobtain 17 mg of the compound presented in the title (26% yield).

1H-NMR (270 MHz, CDCl₃):δ0.96 and 1.00 (d, 3H, J=6.9 Hz), 1.1–1.3 (m,1H), 1.5–2.5 (m, 22H), 2.94 (s, 3H), 3.0 (s, 3H), 3.65–3.8 (m, 1H),3.9–4.05 and 4.1–4.2 (m, 1H), 5.2–5.3 (m, 1H), 5.45–5.65 (m, 2H).

REFERENCE EXAMPLE 16 Preparation of(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(3-N,N-dimethylcarbamoylpropyl)-1H-cyclopenta[b]benzofuran

20 mg of(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(3-carboxypropyl)-1H-cyclopenta[b]benzofuran was taken and dissolved in 2 mL of dimethylformamide. 16 mgof 1,1′-carbonyldiimidazole was added and stirred at 50° C. for 1 hour.13 mg of imidazole and 16 mg of dimethylamine hydrochloride was added,and stirred at 50° C. for 1 hour. An aqueous solution saturated withammonium chloride was added and extracted with ethyl acetate. Theorganic layer was washed with a saturated saline solution, and driedwith anhydrous sodium sulfate. After filtration and concentration, itwas subjected to a silicagel column chromatography, to obtain 5 mg ofthe compound presented in the title (23% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.9–1.1 (m, 3H), 1.2–1.7 (m, 5H), 1.79 (brs,3H), 1.9–2.8 (m, 9H), 2.96 (s, 3H), 3.0 (s, 3H), 3.49 (t, 1H, J=8.5 Hz),3.9–4.3 (m, 2H), 5.0–5.2 (m, 1H), 5.5–5.8 (m, 2H), 6.7–6.85 (m, 1H),6.9–7.05 (m, 2H).

EXAMPLE 1 Preparation of(1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene

29 mg of(1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octeneobtained in Reference example 3 was taken and dissolved in 4 mL oftetrahydrofurane. 20 mg of lithium aluminium hydride was added, andstirred for 4 hours. 100 μL of an aqueous solution saturated with sodiumsulfate was added, then 500 mg of anhydrous sodium sulfate was added,and stirred for 18 hours. A filtration was performed over celite, andafter washing the residue with ethyl acetate, the filtrate wasconcentrated and subjected to a silicagel column chromatography, toobtain 8 mg of the compound presented in the title (29% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.7–1.0 (m, 6H), 1.0–1.6 (m, 16H), 1.8–2.1(m, 4H), 2.2–2.5 (m, 3H), 2.72 (t, 2H, J=7.0 Hz), 2.7–3.1 (m, 5H), 3.76(q, 1H, J=8.6 Hz), 4.0–4.15 (m, 1H), 5.27 (brs, 1H), 5.4–5.6 (m, 2H).

EXAMPLE 2

The compound shown in Table 4 was obtained with a method identical toExample 1.

TABLE 4 NMR data Example No. starting material product Yield % δ 2(1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(5- 17 0.7–1.0(m, 3H), 1.0–1.6carbamoylbutyl)-6- aminopentyl)-6- (m, 15H), 1.8–2.1(m,[(3S,1E)-3-hydroxy-1- [(3S,1E)-3-hydroxy-1- 4H), 2.2–2.5(m, 3H), 2.73octenyl]-7-hydroxy- octenyl]-7-hydroxy (t, 2H, J=7.0Hz), 2.7–3.1bicyclo[3.3.0]-2-octene bicyclo[3.3.0]-2-octene (m, 5H), 3.6–3.85(m,1H), 4.0–4.15(m, 1H), 5.26(brs, 1H), 5.4–5.6(m, 2H)

EXAMPLE 3 Preparation of(1S,5S,6R,7R)-3-(5-N-acetylaminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octene

20 μL of acetic acid was dissolved in 2 mL of dimethylformamide. Afteradding 60 mg of 1,1′-carbonyldiimidazole, it was stirred at 50° C. for 1hour. It was cooled to ambient temperature, and 18 mg of(1S,5S,6R,7R)-3-(5-aminopentyl)-6-[(3S,5S,1E)-3-hydroxy-5-methyl-1-nonenyl]-7-hydroxybicyclo[3.3.0]-2-octenewas added, and stirred for 18 hours. An aqueous solution saturated withpotassium hydrogen sulfate was added and extracted with ethyl acetate.The organic layer was washed with an aqueous solution saturated withsodium bicarbonate, then with a saturated saline solution, and driedwith anhydrous sodium sulfate. After filtration and concentration, itwas subjected to silicagel column chromatography, to obtain 3.5 mg ofthe compound presented in the title (22% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.7–1.0 (m, 6H), 1.0–1.6 (m, 16H), 1.96 (s,3H), 1.8–2.1 (m, 4H), 2.2–2.5 (m, 3H), 2.7–3.1 (m, 3H), 3.1–3.4 (m, 2H),3.76 (q, 1H, J=8.6 Hz), 4.0–4.15 (m, 1H), 5.27 (brs, 1H), 5.4–5.6 (m,2H), 6.6–6.8 (m, 1H).

EXAMPLE 4

The compound shown in Table 5 was obtained with a method identical toExample 3.

TABLE 5 starting material NMR data Example No. amine acid product Yield% δ 4 (1S,5S,6R,7R)-3- benzoic (1S,5S,6R,7R)-3-(5- 37 0.7–1.0(m, 6H),1.0–1.6 (5-aminopentyl)-6- acid N-benzoylamino- (m, 16H), 1.8–2.1(m,[(3S,5S,1E)-3- pentyl)-6-[(3S,5S,1E)- 4H), 2.2–2.5(m, 3H),hydroxy-5-methyl- 3-hydroxy-5-methyl- 2.7–3.1(m, 3H), 3.3–3.51-nonenyl]-7- 1-nonenyl]-7-hydroxy- (m, 2H), 3.77(q, 1H, hydroxybicyclo-bicyclo[3.3.0]-2- J=8.5Hz), 4.0–4.15(m, [3.3.0]-2-octene octene 1H),5.27(brs, 1H), 5.4–5.6(m, 2H), 7.0–7.2 (m, 1H), 7.2–7.5(m, 3H),7.7–7.85(m, 2H)

EXAMPLE 5 Preparation of(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

36 mg of(1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octenewas taken and was dissolved in 1.5 mL of dimethylformamide. Afteraddition of 32 mg of 1,1′-carbonyldiimidazole, it was stirred at 50° C.for 1 hour. It was then cooled to ambient temperature, 27 mg ofimidazole was added, and 33 mg of dimethylamine hydrochloride wasfurther added. After stirring at 50° C. for 1.5 hours, an aqueoussolution saturated with ammonium chloride was added and extraction wasperformed with ethyl acetate. The organic layer was washed with asaturated saline solution, and dried with anhydrous sodium sulfate.After filtration and concentration, 1.5 mL of tetrahydrofurane wasadded. While stirring on ice, 38 mg of lithium aluminium hydride wasadded and stirring continued at 0° C. for 15 minutes, then at 50° C. for1.5 hours. While stirring at ambient temperature, 200 μL of an aqueoussolution saturated with sodium sulfate was added, then 800 mg ofanhydrous sodium sulfate and 4 mL of ethyl acetate were added, andstirred for 1 hour. A filtration was performed over celite, and afterwashing the residue with ethyl acetate, the filtrate was concentratedand subjected to silicagel column chromatography, to obtain 19 mg of thecompound presented in the title (51% yield).

1H-NMR (270 MHz, CDCl₃):δ0.91 (brt, 3H, J=6.9 Hz), 1.16 (s, 3H), 1.2–1.6(m, 15H), 1.8–2.5 (m, 11H), 2.24 (s, 6H), 2.9–3.1 (m, 1H), 3.7–3.9 (m,1H), 5.27 (brs, 1H), 5.3–5.5 (m, 1H), 5.5–5.7 (m, 1H).

EXAMPLES 6–16

The compounds shown in Table 6 were obtained with a method identical toExample 5.

TABLE 6 NMR data Example No. starting material product Yield % δ 6(1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(5- 46 0.92(brt, 3H, J=6.8Hz),carboxybutyl)-6- N,N-dimethylamino- 1.2–1.6(m, 15H), 1.8–2.5[(3S,1E)-3-hydroxy- pentyl)-6-[(3S,1E)-3- (m, 11H), 2.23(s, 6H),1-octenyl]-7-hydroxy- hydroxy-1-octenyl]-7- 2.9–3.1(m, 1H), 3.7–3.9bicyclo[3.3.0]-2-octene hydroxybicyclo[3.3.0]- (m, 1H), 4.1–4.2(m, 1H),2-octene 5.27(brs, 1H), 5.4–5.6(m, 2H) 7 (1S,5S,6R,7R)-3-(4-(1S,5S,6R,7R)-3-(5- 47 0.7–1.0(m, 6H), 1.1–1.7 carboxybutyl)-6-N,N-dimethylamino- (m, 15H), 1.75–2.2(m, [(3S,5S,1E)-3-hydroxy-pentyl)-6-[(3S,5S,1E)-3- 7H), 2.23(s, 6H), 2.1–2.5 5-methyl-1-nonenyl]-hydroxy-5-methyl-1- (m, 5H), 2.9–3.1(m, 1H), 7-hydroxybicyclo-nonenyl]-7-hydroxy- 3.7–3.8(m, 1H), 4.1–4.2 [3.3.0]-2-octenebicyclo[3.3.0]-2-octene (m, 1H), 5.27(brs, 1H), 5.4–5.6(m, 2H) 8(1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(5- 38 0.7–1.0(m, 6H), 1.1–1.6carboxybutyl)-6- N,N-dimethylamino- (m, 15H), 1.75–2.2(m,[(3S,5R,1E)-3-hydroxy- pentyl)-6-[(3S,5R,1E)-3- 7H), 2.23(s, 6H),2.2–2.5 5-methyl-1-nonenyl]-7- hydroxy-5-methyl-1- (m, 5H), 2.9–3.1(m,1H), hydroxybicyclo[3.3.0]- nonenyl]-7-hydroxy 3.7–3.8(m, 1H), 4.1–4.22-octene bicyclo[3.3.0]-2-octene (m, 1H), 5.26(brs, 1H), 5.4–5.6(m, 2H)9 (1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(5- 17 0.92(brt, 3H, J=7.0Hz),carboxybutyl)-6- N,N-dimethylamino- 1.16(s, 3H), 1.2–1.6(m,[(4R,1E)-4-hydroxy- pentyl)-6-[(4R,1E)-4- 15H), 1.8–2.5(m, 11H),4-methyl-1-octenyl]- hydroxy-4-methyl-1- 2.24(s, 6H), 2.9–3.1(m,7-hydroxybicyclo- octenyl]-7-hydroxy 1H), 3.7–3.9(m, 1H), 5.26[3.3.0]-2-octene bicyclo[3.3.0]-2-octene (brs, 1H), 5.3–5.5(m, 1H),5.5–5.7(m, 1H) 10 (1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(5- 34 0.95 and1.00(d, 3H, carboxybutyl)-6- N,N-dimethylamino- J=2.3Hz), 1.1–1.7(m,[(3S,1E)-3-hydroxy-4- pentyl)-6-[(3S,1E)-3- 10H), 1.8–2.5(m, 14H),methyl-6-octyne-1- hydroxy-4-methyl-6- 2.24(s, 6H), 2.9–3.1(m,enyl]-7-hydroxy- octyne-1-enyl]-7- 1H), 3.7–3.9(m, 1H),bicyclo[3.3.0]-2-octene hydroxybicyclo- 4.1–4.2(m, 1H), 5.26(brs,[3.3.0]-2-octene 1H), 5.4–5.6(m, 2H) 11 (1S,5S,6R,7R)-3-(4-(1S,5S,6R,7R)-3-(5- 50 1.1–1.6(m, 16H), 1.8–2.5 carboxybutyl)-6-N,N-dimethylamino- (m, 11H), 2.24(s, 6H), [(3S,1E)-3-hydroxy-pentyl)-6-[(3S,1E)-3- 2.9–3.1(m, 1H), 3.7–3.9 3-cyclopentyl-1-hydroxy-3-cyclopentyl- (m, 1H), 4.1–4.2(m, 1H), propenyl]-7-hydroxy1-propenyl]-7-hydroxy- 5.25(brs, 1H), 5.35–5.7 bicyclo[3.3.0]-2-octenebicyclo[3.3.0]-2-octene (m, 2H) 12 (1S,5S,6R,7R)-3-(4-(1S,5S,6R,7R)-3-(5- 39 1.1–1.6(m, 18H), 1.8–2.5 carboxybutyl)-6-N,N-dimethylamino (m, 11H), 2.24(s, 6H), [(3S,1E)-3-hydroxy-3-pentyl)-6-[(3S,1E)-3- 2.9–3.1(m, 1H), 3.7–3.9 cyclohexyl-1-propenyl]-hydroxy-3-cyclohexyl- (m, 1H), 4.1–4.2(m, 1H), 7-hydroxybicyclo-1-propenyl]-7-hydroxy- 5.24(brs, 1H), 5.3–5.7(m, 2H) [3.3.0]-2-octenebicyclo[3.3.0]-2-octene 13 (1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(5- 431.1–1.75(m, 18H), 1.8–2.6 carboxybutyl)-6- N,N-dimethylamino (m, 11H),2.24(s, 6H), [(3S,1E)-3-hydroxy-4- pentyl)-6-[(3S,1E)-3- 2.9–3.1(m, 1H),3.7–3.9 cyclopentyl-1-butenyl]- hydroxy-4-cyclopentyl- (m, 1H),4.1–4.2(m, 1H), 7-hydroxybicyclo- 1-butenyl]-7-hydroxy- 5.25(brs, 1H),5.4–5.6(m, 2H) [3.3.0]-2-octene bicyclo[3.3.0]-2-octene 14(1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(5- 44 0.93(brt, 3H, J=6.9Hz),carboxybutyl)-6- N,N-dimethylamino- 1.2–1.7(m, 15H), 1.8–2.5[(3R,1E)-3-hydroxy-1- pentyl)-6-[(3R,1E)-3- (m, 11H), 2.24(s, 6H),octenyl]-7-hydroxy- hydroxy-1-octenyl]-7- 2.9–3.1(m, 1H), 3.7–3.9bicyclo[3.3.0]-2-octene hydroxybicyclo- (m, 1H), 4.1–4.2(m, 1H),[3.3.0]-2-octene 5.28 (brs, 1H), 5.4–5.6(m, 2H) 15 (1S,5S,6R,7R)-3-(2-(1S,5S,6R,7R)-3-[2-(2- 21 0.94(brt, 3H, J=6.9Hz), carboxymethyloxy-N,N-dimethylamino- 1.2–1.6(m, 9H), 1.8–2.5 ethyl)-6-[(3S,1E)-3-ethyl)oxyethyl]-6-[(3S,1E)- (m, 11H), 2.24(s, 6H), hydroxy-1-octenyl]-7-3-hydroxy-1- 2.8–3.1(m, 1H), 3.4–4.2 hydroxybicyclo- octenyl]-7-hydroxy(m, 6H), 5.28(brs, 1H), [3.3.0]-2-octene bicyclo[3.3.0]-2-octene5.4–5.7(m, 2H) 16 (1S,5S,6R,7R)-3-(2- (1S,5S,6R,7R)-3-[2-(2- 150.91(brt, 3H, J=6.8Hz), carboxymethylthio- N,N-dimethylamino- 1.2–1.6(m,9H), 1.8–2.5 ethyl)-6-[(3S,1E)-3- ethyl)thioethyl]-6- (m, 11H), 2.23(s,6H), hydroxy-1-octenyl]-7- [(3S,1E)-3-hydroxy-1- 2.9–3.4(m, 5H), 3.7–3.9hydroxybicyclo- octenyl]-7-hydroxy (m, 1H), 4.1–4.2(m, 1H),[3.3.0]-2-octene bicyclo[3.3.0]-2-octene 5.26(brs, 1H), 5.4–5.6(m, 2H)

EXAMPLE 17 Preparation of(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene

39 mg of(1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octeneobtained in Reference example 6 was taken, 4 mL of tetrahydrofuran wasadded, then 36 mg of lithium aluminium hydride was added, and stirred atambient temperature for 5 hours. While stirring at ambient temperature,100 μL of an aqueous solution saturated with sodium sulfate was added,then 300 mg of anhydrous sodium sulfate was added, and stirred for 1.5hours. A filtration was performed over celite, and after washing theresidue with ethyl acetate, the filtrate was concentrated and subjectedto a silicagel column chromatography, to obtain 26 mg of the compoundpresented in the title (70% yield).

1H-NMR (270 MHz, CDCl₃): δ 1.2–1.6 (m, 7H), 1.7–2.1 (m, 7H), 2.22 (s,6H), 2.33 (s, 3H), 2.2–2.5 (m, 4H), 2.7–2.9 (m, 2H), 2.9–3.1 (m,1H)3.55–3.7 (m, 1H), 4.34 (q, 1H, J=6.5 Hz), 5.26 (brs, 1H), 5.45 (dd,1H, J=15.8, 8.2 Hz), 5.59 (dd, 1H, J=15.5, 6.6 Hz), 6.9–7.1 (m, 3H),7.1–7.25 (m, 1H).

EXAMPLES 18–26

The compounds shown in Table 7 were obtained with a method identical toExample 17.

TABLE 7 NMR data Example No. starting material product Yield % δ 18(1S,5S,6R,7R)-3-[4-N- (1S,5S,6R,7R)-3- 68 0.91(brt, 3H, J=6.6Hz),(2-ethoxycarbonylethyl)- [5-N-(3-hydroxypropyl)- 1.16(s, 3H), 1.1–2.5(m,carbamoylbutyl]-6- aminopentyl]-6- 29H), 2.9–3.1(m, 1H),[(4S,1E)-4-hydroxy-4- [(4S,1E)-4-hydroxy-4- 3.41(q, 2H, J=6.1Hz),methyl-1-octenyl]-7- methyl-1-octenyl]-7- 3.63(t, 2H, J=5.4Hz),hydroxybicyclo[3.3.0]- hydroxybicyclo- 4.7–4.9(m, 1H), 5.29(brs,2-octene [3.3.0]-2-octene 1H), 5.41(dd, 1H, J=15.4, 8.4Hz), 5.5–5.7(m,1H), 5.9–6.0(m, 1H) 19 (1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3- 430.7–1.0(m, 6H), 1.04(t, N,N-diethylcarbamoyl- (5-N,N-diethylamino- 6H,J=7.2Hz), 1.1–1.6(m, butyl)-6-[(3S,5S,1E)- pentyl)-6-[(3S,5S,1E)- 15H),1.75–2.2(m, 7H), 3-hydroxy-5-methyl-1- 3-hydroxy-5-methyl-1- 2.2–2.5(m,5H), 2.56(q, nonenyl]-7-hydroxy- nonenyl]-7-hydroxy- 4H, J=6.4Hz),2.9–3.1(m, bicyclo[3.3.0]-2-octene bicyclo[3.3.0]-2-octene 1H),3.7–3.8(m, 1H), 4.1–4.2(m, 1H), 5.27(brs, 1H), 5.4–5.6(m, 2H) 20(1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3-(5- 50 0.7–1.0(m, 6H), 1.0–1.6morpholinocarbonyl- morpholinopentyl)-6- (m, 15H), 1.75–2.1(m,butyl)-6-[(3S,5S,1E)- [(3S,5S,1E)-3-hydroxy- 5H), 2.1–2.65(m, 10H),3-hydroxy-5-methyl-1- 5-methyl-1-nonenyl]- 2.9–3.1(m, 1H), 3.6–3.8nonenyl]-7-hydroxy- 7-hydroxybicyclo- (m, 6H), 4.0–4.2(m, 1H),bicyclo[3.3.0]-2-octene [3.3.0]-2-octene 5.26(brs, 1H), 5.4–5.6(m, 2H)21 (1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3- 81 0.7–1.0(m, 6H), 1.0–1.7piperidinocarbonylbutyl)- (5-piperidinopentyl)-6- (m, 21H), 1.7–2.1(m,6-[(3S,5S,1E)-3-hydroxy- [(3S,5S,1E)-3-hydroxy- 9H), 2.2–2.5(m, 7H),5-methyl-1-nonenyl]-7- 5-methyl-1-nonenyl]-7- 2.9–3.1(m, 1H), 3.7–3.85hydroxybicyclo[3.3.0]-2- hydroxybicyclo- (m, 1H), 4.1–4.25(m, octene[3.3.0]-2-octene 1H), 5.27(brs, 1H), 5.45–5.6(m, 2H) 22(1S,5S,6R,7R)-3-[4- (1S,5S,6R,7R)-3-[5-N- 89 0.8–0.95(m, 6H), 1.0–2.1N-(4-pyridylmethyl)- (4-pyridylmethyl)amino- (m, 18H), 2.04(t, 2H,carbamoylbutyl]-6- pentyl]-6-[(3S,5S,1E)- J=8.5Hz), 2.27(t, 2H,[(3S,5S,1E)-3-hydroxy- 3-hydroxy-5-methyl-1- J=7.4Hz), 2.2–2.5(m,5-methyl-1-nonenyl]- nonenyl]-7-hydroxy- 5H), 2.9–3.1(m, 1H),7-hydroxybicyclo- bicyclo[3.3.0]-2-octene 3.7–3.85(m, 1H), 4.1–4.2[3.3.0]-2-octene (m, 1H), 4.46 (d, 2H, J=5.9Hz), 5.27(brs, 1H),5.45–5.6(m, 2H), 5.9–6.0 (m, 1H), 7.20(d, 2H, J=5.9Hz), 8.54(d, 2H,J=5.9Hz) 23 (1S,5S,6R,7R)-3-(4- (1S,5S,6R,7R)-3- 43 1.2–1.55(m, 7H),1.8–2.1 N,N-dimethyl- (5-N,N-dimethylamino- (m, 7H), 2.23(s, 6H),carbamoylbutyl)-6- pentyl)-6-[(3S,1E)-3- 2.33(s, 3H), 2.1–2.5(m,[(3S,1E)-3-hydroxy-4- hydroxy-4-(m-tolyl)-1- 4H), 2.7–2.9(m, 2H),(m-tolyl)-1-butenyl]-7- butenyl]-7-hydroxy 2.9–3.1(m, 1H), 3.6–3.8hydroxybicyclo- bicyclo[3.3.0]-2-octene (m, 1H), 4.32(q, 1H,[3.3.0]-2-octene J=6.5Hz), 5.26(brs, 1H), 5.49(dd, 1H, J=15.3, 8.5Hz),5.60(dd, 1H, J=15.4, 6.2Hz), 6.9–7.1 (m, 3H), 7.1–7.25(m, 1H) 24(1S,5S,6R,7R)-3- (1S,5S,6R,7R)-3- 70 1.2–1.55(m, 7H), 1.6–2.1(4-N,N-dimethyl- (5-N,N-dimethylamino- (m, 7H), 2.22(s, 6H),carbamoylbutyl)-6- pentyl)-6-[(3R,1E)-3- 2.33(s, 3H), 2.1–2.5(m,[(3R,1E)-3-hydroxy-4- hydroxy-4-(m-tolyl)-1- 4H), 2.75–2.9(m, 2H),(m-tolyl)-1-butenyl]-7- butenyl]-7-hydroxy- 2.9–3.1(m, 1H), 3.5–3.7hydroxybicyclo- bicyclo[3.3.0]-2-octene (m, 1H), 4.33(q, 1H,[3.3.0]-2-octene J=6.5Hz), 5.26(brs, 1H), 5.45(dd, 1H, J=15.8, 8.2Hz),5.59(dd, 1H, J=15.5, 6.6Hz), 6.9–7.1 (m, 3H), 7.1–7.2(m, 1H) 25(1S,5S,6R,7R)-3- (1S,5S,6R,7R)-3- 81 1.2–2.1(m, 13H), 2.22(s,(4-N,N-dimethyl- (5-N,N-dimethylamino- 6H), 2.33(s, 3H),carbamoylbutyl)-6- pentyl)-6-[(E)-4- 2.15–2.5(m, 6H), 2.5–2.7[(E)-4-(m-tolyl)-1- (m-tolyl)-1-butenyl]-7- (m, 2H), 2.9–3.05(m,butenyl]-7-hydroxy- hydroxybicyclo- 1H), 3.5–3.7(m, 1H),bicyclo[3.3.0]-2-octene [3.3.0]-2-octene 5.2–5.3(m, 2H), 5.45–5.6 (m,1H), 6.9–7.1(m, 3H), 7.1–7.2(m, 1H) 26 (1S,5S,6R,7R)-3- (1S,5S,6R,7R)-3- 7 1.2–1.7(m, 7H), 2.33(s, (4-N,N-dimethyl- (5-N,N-dimethylamino- 9H),1.7–2.7(m, 14H), carbamoylbutyl)-6- pentyl)-6-[(1E,3E)-6- 2.9–3.1(m,1H), 3.5–3.7 [(1E,3E)-6-(m-tolyl)- (m-tolyl)-1,3-hexa- (m, 1H),5.30(brs, 1H), 1,3-hexadienyl]-7- dienyl]-7-hydroxy- 5.35–5.55(m, 1H),hydroxybicyclo- bicyclo[3.3.0]-2-octene 5.55–5.75(m, 1H), 5.9–6.2[3.3.0]-2-octene (m, 2H), 6.8–7.05(m, 3H), 7.05–7.2(m, 1H)

EXAMPLE 27 Preparation of(1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene

24 mg of(1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octenewas taken and dissolved in 2 mL of dimethylformamide. 25 mg of1,1′-carbonyldiimidazole was added and stirred at 50° C. for 1.5 hours.It was then cooled to ambient temperature and 100 mg pyrrolidine wasadded. After stirring at 50° C. for 2 hours, an aqueous solutionsaturated with ammonium chloride was added and extracted with ethylacetate. The organic layer was washed with a saturated saline solution,and dried with anhydrous sodium sulfate. After filtration andconcentration, 3 mL of tetrahydrofurane was added. While stirring onice, 112 mg of lithium aluminium hydride was added, and stirringcontinued at 50° C. for 3 hours. While stirring at ambient temperature,200 μL of an aqueous solution saturated with sodium sulfate was added,then 1 g of anhydrous sodium sulfate was added- and stirred for 16hours. A filtration was performed over celite, and after washing theresidue with ethyl acetate, the filtrate was concentrated and subjectedto silicagel column chromatography, to obtain 18 mg of the compoundpresented in the title (65% yield).

1H-NMR (270 MHz, CDCl₃): δ1.2–1.6 (m, 7H), 1.7–2.1 (m, 10H), 2.33 (s,3H), 2.15–2.7 (m, 12H), 2.8–3.1 (m, 1H), 3.5–3.7 (m, 1H), 5.15–5.3 (m,2H), 5.45–5.65 (m, 1H), 6.9–7.1 (m, 3H), 7.1–7.2 (m, 1H).

EXAMPLES 28–33

The compounds shown in Table 8 were obtained with a method identical toExample 27.

TABLE 8 starting material NMR data Example No. carboxylic acid amineproduct Yield % δ 28 (1S,5S,6R,7R)-3- methylamine (1S,5S,6R,7R)-3- 330.94(brt, 3H, J=6.9Hz), (4-carboxybutyl)- (5-N-methylamino- 1.2–1.6(m,16H), 1.8–2.6 6-[(3S,1E)-3- pentyl)-6-[(3S,1E)- (m, 11H), 2.42(s, 3H),hydroxy-1-octenyl]- 3-hydroxy-1-octenyl]- 2.9–3.1(m, 1H), 3.7–3.97-hydroxybicyclo- 7-hydroxybicyclo- (m, 1H), 4.1–4.2(m, 1H),[3.3.0]-2-octene [3.3.0]-2-octene 5.28(brs, 1H), 5.4–5.6(m, 2H) 29(1S,5S,6R,7R)-3- cyclohexylamine (1S,5S,6R,7R)-3- 14 0.93(brt, 3H,J=6.9Hz), (4-carboxybutyl)- (5-N-cyclohexyl- 0.9–2.5(m, 37H), 2.9–3.16-[(3S,1E)-3- aminopentyl)-6- (m, 1H), 3.7–3.9(m, 1H),hydroxy-1-octenyl]- [(3S,1E)-3-hydroxy- 4.1–4.2(m, 1H), 5.26(brs,7-hydroxybicyclo- 1-octenyl]-7-hydroxy- 1H),5.4–5.6(m, 2H)[3.3.0]-2-octene bicyclo[3.3.0]-2-octene 30 (1S,5S,6R,7R)-3- benzylamine(1S,5S,6R,7R)-3- 33 0.92(brt, 3H, J=6.7Hz), (4-carboxybutyl)-(5-N-benzylamino- 1.1–1.7(m, 16H), 1.8–2.7 6-[(3S,1E)-3-pentyl)-6-[(3S,1E)- (m, 11H), 2.9–3.1(m, hydroxy-1-octenyl]-3-hydroxy-1-octenyl]- 1H), 3.77(s, 2H), 3.7–3.9 7-hydroxybicyclo-7-hydroxybicyclo- (m, 1H), 4.1–4.2(m, 1H), [3.3.0]-2-octene[3.3.0]-2-octene 5.27(brs, 1H), 5.4–5.6(m, 2H), 7.1–7.3(m, 5H) 31(1S,5S,6R,7R)-3- N-methylpiperazine (1S,5S,6R,7R)-3- 23 0.92(brt, 3H,J=6.8Hz), (4-carboxybutyl)- [5-(4-N-methyl-1- 1.2–1.6(m, 15H), 1.8–2.96-[(3S,1E)-3- piperazinyl)pentyl]-6- (m, 19H), 2.29(s, 3H),hydroxy-1-octenyl]- [(3S,1E)-3-hydroxy- 2.9–3.1(m, 1H), 3.7–3.97-hydroxybicyclo- 1-octenyl]-7-hydroxy- (m, 1H), 4.1–4.2(m, 1H),[3.3.0]-2-octene bicyclo[3.3.0]-2-octene 5.28(brs, 1H), 5.4–5.6(m, 2H)32 (1S,5S,6R,7R)-3- Butylamine (1S,5S,6R,7R)-3- 41 0.7–1.0(m, 6H),1.17(s, (4-carboxybutyl)- (5-N-butylamino- 3H), 1.2–1.6(m, 19H),6-[(4R,1E)-4- pentyl)-6-[(4R,1E)-4- 1.8–2.7(m, 14H), 2.9–3.1hydroxy-4-methyl- hydroxy-4-methyl-1- (m, 1H), 3.7–3.9(m, 1H),1-octenyl]-7- octenyl]-7-hydroxy- 5.27(brs, 1H), 5.3–5.5(m,hydroxybicyclo- bicyclo[3.3.0]-2- 1H), 5.5–5.7(m, 1H) 3.3.0]-2-octeneoctene 33 (1S,5S,6R,7R)-3- morpholine (1S,5S,6R,7R)-3- 87 1.2–1.6(m,6H), 1.6–2.1 (4-carboxybutyl)-6- (5-morpholinopentyl)- (m, 11H), 2.33(s,3H), [(E)-4-(m-tolyl)-1- 6-[(E)-4-(m-tolyl)-1- 2.1–2.5(m, 6H), 2.5–2.75butenyl]-7-hydroxy- butenyl]-7-hydroxy- (m, 2H), 2.8–3.1(m, 1H),bicyclo[3.3.0]-2-octene bicyclo[3.3.0]-2- 3.5–3.75(m, 5H)5.2–5.3 octene(m, 2H)5.4–5.6(m, 1H), 6.9–7.05(m, 3H), 7.1–7.2(m, 1H)

EXAMPLE 34 Preparation of(1S,5S,6R,7R)-3-(5-N,N-diisopropylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene

29 mg of(1S,5S,6R,7R)-3-(4-N,N-diisopropylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-(tetrahydropyran-2-yloxy)-bicyclo[3.3.0]-2-octeneobtained in Reference example 14 was dissolved in 5 mL oftetrahydrofuran and 118 mg of lithium aluminium hydride was added. Afterstirring at 50° C. for 2 hours, 150 μL of an aqueous solution saturatedwith sodium sulfate was added, then anhydrous sodium sulfate was furtheradded, and stirred for 18 hours. After filtration and concentration, theobtained oily matter was dissolved in 5 mL of methanol, and 20 mg ofp-toluene sulfonic acid monohydrate was added. After stirring for 1.5hours, an aqueous solution of potassium carbonate was added. Afterconcentration extraction was performed with ethyl acetate, and theorganic layer was washed with a saturated saline solution. It was thendried with anhydrous sodium sulfate, filtered, concentrated, andsubjected to a silicagel column chromatography, to obtain 3 mg of thecompound presented in the title (12% yield).

1H-NMR (270 MHz, CDCl₃): δ 1.03 (d, 12H, J=6.2 Hz), 1.2–2.1 (m, 14H),2.2–2.5 (m, 5H), 2.33 (s, 3H), 2.55–2.75 (m, 2H), 2.8–3.2 (m, 3H),3.6–3.7 (m, 1H), 5.2–5.3 (m, 2H), 5.4–5.7 (m, 1H), 6.9–7.1 (m, 3H),7.1–7.25 (m, 1H).

EXAMPLE 35 Preparation of(1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane

14 mg of(1S,2R,3R,5S)-7-[(E)-4-N,N-dimethylcarbamoylbutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octaneobtained in Reference example 15 was taken and 4 mL of tetrahydrofuranwas added. In addition, while stirring on ice, 15 mg of lithiumaluminium hydride was added and stirred at ambient temperature for 4hours. While stirring at ambient temperature, 100 μL of an aqueoussolution saturated with sodium sulfate was added, 300 mg anhydroussodium sulfate was added, and stirred for 16 hours. A filtration wasperformed over celite, and after washing the residue with ethyl acetate,the filtrate was concentrated and subjected to a silicagel columnchromatography, to obtain 9 mg of the compound presented in the title(65% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.96 and 1.01 (d, 3H, J=6.8 Hz), 1.1–1.6 (m,7H), 1.79 (t, 3H, J=2.4 Hz), 2.24 (s, 6H), 1.7–2.5 (m, 15H), 3.7–3.9 (m,1H), 3.9–4.2 (m, 1H), 5.2–5.3 (m, 1H), 5.4–5.6 (m, 2H).

EXAMPLE 36 Preparation of(1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octane

28 mg of(1S,2R,3R,5S)-7-[(E)-4-carboxybutylidene]-2-[(3,1E)-3-hydroxy-1-octenyl]-3-hydroxybicyclo[3.3.0]octanewas taken and was dissolved in 1.5 mL of dimethylformamide. 35 mg of1,1′-carbonyldiimidazole was added and stirred at 50° C. for 1 hour. Itwas then cooled to ambient temperature, 27 mg of imidazole was added,and 33m of dimethylamine hydrochloride was also added. After stirring at50° C. for 1.5 hours, an aqueous solution saturated with ammoniumchloride was added and extraction was performed with ethyl acetate. Theorganic layer was washed with a saturated saline solution, and driedwith anhydrous sodium sulfate. After filtration and concentration, 1.5mL of tetrahydrofurane was added. While stirring on ice, 38 mg oflithium aluminium hydride was added and stirring continued at 0° C. for15 minutes, then at 50° C. for 1.5 hours. While stirring at ambienttemperature, 200 μL of an aqueous solution saturated with sodium sulfatewas added, then 800 mg of anhydrous sodium sulfate and 4 mL of ethylacetate were added, and stirred for 1 hour. A filtration was performedover celite, and after washing the residue with ethyl acetate, thefiltrate was concentrated and subjected to a silicagel columnchromatography, to obtain 11 mg of the compound presented in the title(41% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.93 (brt, 3H, J=6.8 Hz), 1.1–1.6 (m, 12H),2.24 (s, 6H), 1.7–2.5 (m, 15H), 3.7–3.9 (m, 1H), 3.9–4.2 (m, 1H),5.2–5.3 (m, 1H), 5.4–5.6 (m, 2H).

EXAMPLE 37

The compound shown in Table 9 was obtained with a method identical toExample 36.

TABLE 9 NMR data Example No. starting material product Yield % δ 37(1S,2R,3R,5S)-7-[(E)- (1S,2R,3R,5S)-7-[(E)- 37 1.0–1.7(m, 13H), 2.23(s,4-carboxybutylidene]- 5-N,N-dimethylamino- 6H), 1.7–2.5(m, 15H),2-[(3S,1E)-3-hydroxy- pentylidene]-2-[(3S,1E)- 3.7–3.9(m, 1H), 3.9–4.23-cyclopentyl-1- 3-hydroxy-3-cyclopentyl- (m, 1H), 5.2–5.3(m, 1H),propenyl]-3-hydroxy- 1-propenyl]-3-hydroxy- 5.4–5.6(m, 2H)bicyclo[3.3.0]octane bicyclo[3.3.0]octane

EXAMPLE 38 Preparation of(1S,2R,3R,5S)-7-[(E)-5-morpholinopentylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane

20 mg of(1S,2R,3R,5S)-7-[(E)-4-carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octanewas taken and dissolved in 2 mL of dimethylformamide. After addition of20 mg of 1,1′-carbonyldiimidazole, it was stirred at 50° C. for 1.5hours. It was then cooled to ambient temperature, and 100 mg ofmorpholine was added. After stirring at 50° C. for 2 hours, an aqueoussolution saturated with ammonium chloride was added and extraction wasperformed with ethyl acetate. The organic layer was washed with asaturated saline solution, and dried with anhydrous sodium sulfate.After filtration and concentration, 3 mL of tetrahydrofurane was added.While stirring, 100 mg of lithium aluminium hydride was added, andstirring continued at 50° C. for 3 hours. While stirring at ambienttemperature, 200 μL of an aqueous solution saturated with sodium sulfatewas added, then 1 g of anhydrous sodium sulfate was added, and stirredfor 16 hours. A filtration was performed over celite, and after washingthe residue with ethyl acetate, the filtrate was concentrated andsubjected to a silicagel column chromatography, to obtain 7 mg of thecompound presented in the title (40% yield).

1H-NMR (270 MHz, CDCl₃):δ 0.96 and 1.01 (d, 3H, J=6.8 Hz), 1.1–1.6 (m,7H), 1.79 (t, 3H, J=2.4 Hz), 1.7–2.7 (m, 19H), 3.6–3.9 (m, 5H), 3.9–4.2(m, 1H), 5.2–5.3 (m, 1H), 5.4–5.6 (m, 2H).

EXAMPLES 39–40

The compounds shown in Table 10 were obtained with a method identical toExample 38.

TABLE 10 starting material NMR data Example No. carboxylic acid amineproduct Yield % δ 39 (1S,2R,3R,5S)-7- diethylamine (1S,2R,3R,5S)-7- 350.96 and 1.01(d, 3H, [(E)-4-carboxy- [(E)-5-N,N-diethyl- J=6.8Hz),1.05(t, 6H, butylidene]-2- aminopentylidene]-2- J=7.1Hz), 1.1–1.6(m,[(3S,1E)-3-hydroxy- [(3S,1E)-3-hydroxy- 7H), 1.79(t, 3H,4-methyl-6-octyne-1- 4-methyl-6-octyne- J=2.4Hz), 1.7–2.5(m,enyl]-3-hydroxy- 1-enyl]-3-hydroxy- 15H), 2.55(q, 4H,bicyclo[3.3.0]octane bicyclo[3.3.0]octane J=6.5Hz), 3.7–3.9(m, 1H),3.9–4.2(m, 1H), 5.2–5.3(m, 1H), 5.4–5.6(m, 2H) 40 (1S,2R,3R,5S)-7-pyrrolidine (1S,2R,3R,5S)-7- 42 0.96 and 1.01(d, 3H,[(E)-4-carboxybutyli- [(E)-5-(1-pyrrolidinyl)- J=6.7Hz), 1.1–1.7(m,dene]-2-[(3S,1E)-3-hy- pentylidene]-2- 11H), 1.7–2.7(m, 22H),droxy-4-methyl-6-octyne- [(3S,1E)-3-hydroxy- 3.7–3.9(m, 1H), 3.9–4.21-enyl]-3-hydroxy- 4-methyl-6-octyne-1- (m, 1H), 5.2–5.3(m, 1H),bicyclo[3.3.0]octane enyl]-3-hydroxy- 5.4–5.6(m, 2H)bicyclo[3.3.0]octane

REFERENCE EXAMPLE 17 Preparation of(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1′-octene-6-ynyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran

10 mg of(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-37-hydroxy-4-methyl-1-octene-6-ynyl]-5-(3-carboxypropyl)-1H-cyclopenta[b]benzofuranwas taken and was dissolved in 2 mL of dimethylformamide. After additionof 8.1 mg of 1,1′-carbonyldiimidazole, it was stirred at 50° C. for 1hour. It was then cooled to ambient temperature, 6.8 mg of imidazole wasadded, 8.2 mg dimethylamine hydrochloride was further added. Afterstirring at 50° C. for 1 hour, an aqueous solution saturated withammonium chloride was added and extraction was performed with ethylacetate. The organic layer was washed with a saturated saline solution,and dried with anhydrous sodium sulfate. After filtration andconcentration, 2 mL of tetrahydrofurane was added. While stirring onice, 9.5 mg of lithium aluminium hydride was added, and stirringcontinued at 0° C. for 15 minutes, and at 50° C. for 1 hour. Whilestirring at ambient temperature, 100 μL of an aqueous solution saturatedwith sodium sulfate was added, 400 mg of anhydrous sodium sulfate wasadded, and stirred for 1 hour. A filtration was performed over celite,and after washing the residue with ethyl acetate, the filtrate wasconcentrated and subjected to a silicagel column chromatography, toobtain 7.5 mg of the compound presented in the title (73% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.9–1.1 (m, 3H), 1.2–1.7 (m, 7H), 1.79 (brs,3H), 1.9–2.7 (m, 9H), 2.24 (s, 6H), 3.49 (t, 1H, J=8.5 Hz), 3.9–4.3 (m,2H), 5.0–5.2 (m, 1H), 5.5–5.8 (m, 2H), 6.7–6.85 (m, 1H), 6.9–7.05 (m,2H).

EXAMPLE 41 Preparation of(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(4-morpholinobutyl)-1H-cyclopenta[b]benzofuran

10 mg of(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(3-carboxypropyl)-1H-cyclopenta[b]benzofuranwas taken and was dissolved in 2 mL of dimethylformamide. After additionof 8.1 mg of 1,1′-carbonyldiimidazole, it was stirred at 50° C. for 1hour. It was cooled to ambient temperature, and 50 mg morpholine wasadded. After stirring at 50° C. for 1 hour, an aqueous solutionsaturated with ammonium chloride was added and extracted with ethylacetate. The organic layer was washed with a saturated saline solution,and dried with anhydrous sodium sulfate. After filtration andconcentration, 2 mL of tetrahydrofurane was added. While stirring onice, 9.5 mg of lithium aluminium hydride was added and stirringcontinued at 0° C. for 15 minutes, then at 50° C. for 1 hour. Whilestirring at ambient temperature, 100 μL of an aqueous solution saturatedwith sodium sulfate was added, then 400 mg of anhydrous sodium sulfatewas added, and stirred for 1 hour. A filtration was performed overcelite, and after washing the residue with ethyl acetate, the filtratewas concentrated and subjected to a silicagel column chromatography, toobtain 5.3 mg of the compound presented in the title (48% yield).

1H-NMR (270 MHz, CDCl₃): δ 0.9–1.1 (m, 3H), 1.2–1.7 (m, 7H), 1.78 (brs,3H), 1.9–2.7 (m, 13H), 3.3–3.6 (m, 1H), 3.6–4.3 (m, 6H), 5.0–5.2 (m,1H), 5.5–5.8 (m, 2H), 6.7–6.85 (m, 1H), 6.9–7.05 (m, 2H).

EXAMPLES 42–43

The compounds shown in Table 11 were obtained with a method identical toExample 41.

TABLE 11 NMR data Example No. starting material product Yield % δ 42(1R,2R,3aS,8bS)- (1R,2R,3aS,8bS)- 54 0.9–1.1(m, 3H), 1.2–1.72,3,3a,8b-tetrahydro-2- 2,3,3a,8b-tetrahydro-2- (m, 13H), 1.79(brs, 3H),hydroxy-1-[(3S,1E)-3- hydroxy-1-[(3S,1E)-3- 1.8–2.7(m, 13H), 3.3–3.6hydroxy-4-methyl-1- hydroxy-4-methyl-1- (m, 1Hz), 3.9–4.3(m, 2H),octene-6-ynyl]-5-(3- octene-6-ynyl]-5-(4- 5.0–5.2(m, 1H), 5.5–5.8carboxypropyl)-1H- piperidinobutyl)-1H- (m, 2H), 6.7–6.85(m,cyclopenta[b]benzofuran cyclopenta[b]benzofuran 1H), 6.9–7.05(m, 2H) 43(1R,2R,3aS,8bS)- (1R,2R,3aS,8bS)- 43 0.9–1.1(m, 3H), 1.2–1.72,3,3a,8b-tetrahydro-2- 2,3,3a,8b-tetrahydro-2- (m, 13H), 1.80(brs, 3H),hydroxy-1-[(3S,1E)-3- hydroxy-1-[(3S,1E)-3- 1.8–2.7(m, 11H), 3.3–3.6hydroxy-4-methyl-1- hydroxy-4-methyl-1- (m, 1Hz), 3.9–4.3(m, 2H),octene-6-ynyl]-5-(3- octene-6-ynyl]-5-[4-(1- 5.0–5.2(m, 1H), 5.5–5.8carboxypropyl)-1H- pyrrolidinyl)butyl]-1H- (m, 2H), 6.7–6.85(m,cyclopenta[b]benzofuran cyclopenta[b]benzofuran 1H), 6.9–7.05(m, 2H)

REFERENCE EXAMPLE 18 Method for Measuring The Ability of Learning andMemory in a Rat by the Step-Through Passive Avoidance Test

A step-through passive avoidance instrument made of two chambersseparated by a guillotine door was used as the experimental apparatus.One chamber is an illuminated chamber made of transparent acrylic boards(floor: 15 cm×25 cm, height: 15 cm), the other chamber is a dark chambermade of black acryl boards (same dimensions). In addition, the floor ofthe dark chamber was equipped with a grid made of 4 mm diameterstainless steel pieces separated by 15 mm spacing. The grid wasconnected to an apparatus for delivering electric shocks (shockgenerator scrambler).

First, the guillotine door was opened for one minute to let a rat freelyexplore the interior of the apparatus. Then, for acquisition trials, thedoor was closed and the rat was put into the illuminated chamber. 30seconds later, the door was opened and immediately after the four legsof the rat were put inside the dark chamber, the door was closed and anelectric shock was delivered. The strength of the electric shock was 0.5mA for 5 seconds. The training was repeated until the rat remained inthe illuminated chamber for more than 120 seconds when the rat wasplaced in the illuminated chamber immediately after the electric shockand the door was opened in a similar way. 24 hours after the acquisitiontrials, the rat was put into the illuminating chamber for retentiontrials, 30 seconds after, the guillotine door was opened, and the timetaken for the four legs of the rat to enter the dark chamber wasmeasured (step-through latency). The maximum observation time duringretention trials was set to 300 seconds.

REFERENCE EXAMPLE 19 Method for Measuring the Ability of Learning andMemory in a Rat by the Y-Maze Test (Spontaneous Alternation BehaviorTest)

A Y-shaped maze made by connecting three arms having a length of 35 cmeach, a wall height of 25 cm and a floor width of 10 cm at an angle of120° with respect to each other. The apparatus was settled on thelaboratory floor.

A rat was placed at the extremity of one of the arms, was allowed tofreely explore the maze for 8 minutes, and a record was taken of theorder in which the arms were explored by the rat. By calling (A) the“Total arm entries”, and among them, by calling (B) the “Number ofspontaneous alternations” which is the number of cases where 3 differentarms were selected in sequence, the “Percentage of spontaneousalternations” was calculated with: (B/(A−2))×100.

REFERENCE EXAMPLE 20 Preparation of a Model for Alzheimer's Disease bythe Continuous Intracerebroventricular Administration of β-AmyloidProteins

7 week old Wistar male rats (weight 220 to 250 g) were used (N=5 to 10).

β-amyloid protein (1–42) was dissolved in 35% acetonitrile-0.1%trifluoroacetic acid in water, injected in a mini-osmotic pump, whichhad been set to deliver 300 pmol/day (volume: 230 μL, flow: 0.5μL/hour), and connected to a dental syringe needle through apolyethylene tube. Animals in control group were connected to a pump towhich β-amyloid protein (40–1) orvehicleonly was injected. Afteranesthetizing the rats with pentobarbital (50 mg/Kg, i.p.), an incisionwas performed in each of their scalps, and following the brainatlas,holes were drilled in the cranium. The syringe needle was inserted sothat the tip of the needle was inside the lateral ventricle (A=−0.3 mm,L=1.2 mm, H=4.5 mm), and fixed with dental cement. The osmotic pump wasthen implanted under the dorsal skin.

Taking the day when the mini-osmotic pump was implanted as day 0, on day5, a Y-maze test was performed following the method indicated inReference example 2, on day 13 and day 14, a passive avoidance test wasperformed following the method indicated in Reference example 1, and adecrease in the ability of learning and memory was observed in the groupwhich was administered β-amyloid protein (1–42) in comparison to thegroup which was administered β-amyloid protein (40–1) or the group whichwas administered vehicle only.

REFERENCE EXAMPLE 21 Method for Evaluating the Promotion Activity on theNeurite Outgrowth (1)

Mouse neuroblastoma Neuro2A cells (obtained from DAINIPPONPHARMACEUTICAL CO., LTD.) were suspended with a density of 2.5×10⁴cells/mL in DMEM containing 10% FCS and 2 mM of Gln, and were plated oncommercially available 24-well tissue culture plates with a quantity of400 μL/well. After an overnight culture under the conditions where thetemperature was 37° C., and the carbon dioxide content of the air was5%, the media was exchanged to an identical media containing the testcompound, and the culture was further continued for 24 hours. Thenmicroscope photographs were taken with a 20× lens. Using thephotographs, by counting the total number of cells in the field of viewand the number of cells with extended neurite, the proportion of cellswith extended neurite is calculated.

REFERENCE EXAMPLE 22

Method for Evaluating the Promotion Activity on the Neurite Outgrowth(2)

The cells used and the performed culture method were identical to thosein Reference example (1). After being cultured in a media containing thetest compound for 24 hours, microscope photographs were taken with a 20×lens. Transparent sheets were used to cover the latter photographs, inorder to copy neural projections with a uniform thickness. The copiedsheets were imported into a personal computer as image data, using ascanner. Using image processing software, the area covered by theneurites were calculated, and, since the thickness used to mark theneurite was uniform, the analysis was performed considering that thearea was proportional to the length, and allowing to compute the lengthof neurite per cell.

REFERENCE EXAMPLE 23 Method for Measuring the Activity of DecreasingBlood Pressure

A catheter for monitoring the blood pressure was inserted and placed inthe femoral artery, and a catheter for the administration of drugsolution was inserted and placed in the femoral vein of male Wistar rats(10–11 weeks old, Charles River) under ether anesthesia. The animalswere placed in a Ballman cage, and awakened. After the blood pressurestabilized, a solvent containing ethanol and Tween80 adjusted to thesame amount as those in each administered solution was injected by bolusadministration. After monitoring blood pressure and heart rate for 60minutes to verify the absence of effects, the test compound wasadministered and the blood pressure and the heart rate were furthermonitored for 60 minutes. The doses of the solvent and the test compoundwere all 1 mL/Kg. The measurements of the blood pressure and the heartrate were performed immediately before administration (0 minutes), at 3,5, 10, 15, 30 and 60 minutes after administration. For each animal, theblood pressure value measured at each time point was normalized bydefining the blood pressure at 0 minute as 100.

The test compound was used once it had been dissolved with ethanol anddiluted in physiological saline containing Tween80, with, the quantityof test compound, the concentration of ethanol and Tween80 in theadministration solution for each group as indicated in Table 12 below.

TABLE 12 Dose Concentration of Ethanol Concentration of Tween80 (mg/kg)(%) (%) 0.1 1 0.198 1 10 0.18

REFERENCE EXAMPLE 24 Measurement of the Permeability of the CompoundThrough the Blood Brain Barrier

Bovine cerebral capillary endothelial cells were cultured on a 100 mmdiameter plate (coated with collagen I) to obtain confluency. The cellswere cultured for 15 minutes in an incorporation media (141 mM NaCl, 4mM KCl, 2 mM CaCl₂, 1 mM H₂SO₄, 10 mM HEPES, 10 mM D-glucose) containingthe test compound (1 μM), to incorporate the test compound into thecells. Then, the test compound incorporated into the cells was extractedwith ethanol extraction, and quantified by HPLC. The rate ofincorporation was calculated with the equation below.amount of test compound in the ethanol-extracted fraction/amount of testcompound in the incorporation solution×100(%)

EXAMPLE 44 Measurement of the Ameliorating Effect on Learning and MemoryDeficit (1)

Test compound:(1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The ameliorating effect on learning and memory deficit was evaluatedwith the evaluation methods of Reference examples 18 and 20. The testcompound was dissolved in the β-amyloid protein solution, and injectedat the same time as the β-amyloid protein, using an osmotic pump. Theresults are shown in Table 13 below.

TABLE 1 Time taken to move into the dark chamber during retention trialsmean value ± standard error (unit: seconds) β-amyloid protein(40-1)207.3 ± 51.5 (n = 6) 300 pmol/day group β-amyloid protein(1-42) 140.2 ±53.8 (n = 5) 300 pmol/day group β-amyloid protein(1-42) 217.8 ± 44.9 (n= 6) 300 pmol/day and test compound 12 fmol/day group

The time taken to move into the dark chamber was extended for the testcompound group when compared to the β-amyloid protein(1–42) only group.In other words, in the present experiment, the test compound displayedan activity to ameliorate the learning and memory deficit.

EXAMPLE 45 Measurement of the Ameliorating Effect on Learning and MemoryDeficit (2)

Test compound:(1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

The ameliorating effect on learning and memory deficit was evaluatedwith the evaluation methods of Reference examples 18 and 20. The testcompound was dissolved in the β-amyloid protein solution, and injectedat the same time as the β-amyloid protein, using an osmotic pump. Theresults are shown in Table 14 below.

TABLE 14 Time taken to move into the dark chamber during retentiontrials mean value ± standard error (unit: seconds) β-amyloidprotein(40-1) 263.3 ± 36.7 (n = 3) 300 pmol/day group β-amyloidprotein(1-42) 132.8 ± 58.1 (n = 5) 300 pmol/day group β-amyloidprotein(1-42) 212.2 ± 58.5 (n = 5) 300 pmol/day and test compound 12fmol/day group

The time taken to move into the dark chamber was extended for the testcompound group when compared to the β-amyloid protein(1–42) only group.In other words, in the present experiment, the test compound displayedan activity to ameliorate learning and memory deficit.

EXAMPLE 46 Measurement of the Ameliorating Effect on Learning and MemoryDeficit (3)

Test compound:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The ameliorating effect on learning and memory deficit was evaluatedwith the evaluation methods of Reference examples 18 and 20. The testcompound was dissolved in the β-amyloid protein solution, and injectedat the same time as the β-amyloid protein, using an osmotic pump. Theresults are shown in Table 15 below.

TABLE 15 Time taken to move into the dark chamber during retentiontrials mean value ± standard error (unit: seconds) β-amyloidprotein(40-1) 263.3 ± 36.7 (n = 3) 300 pmol/day group β-amyloidprotein(1-42) 132.8 ± 58.1 (n = 5) 300 pmol/day group β-amyloidprotein(1-42) 242.0 ± 36.3 (n = 4) 300 pmol/day and test compound 12fmol/day group

The time taken to move into the dark chamber was extended for the testcompound group when compared to the β-amyloid protein(1–42) only group.In other words, in the present experiment, the test compound displayedan activity to amliorate learning and memory deficit.

EXAMPLE 47 Measurement of the Ameliorating Effect on Learning and MemoryDeficit (4)

Test compound:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The ameliorating effect on learning and memory deficit was evaluatedwith the evaluation methods of Reference examples 18 and 20. The testcompound was dissolved in the β-amyloid protein solution, and injectedat the same time as the β-amyloid protein, using an osmotic pump. Theresults are shown in Table 16 below.

TABLE 16 Time taken to move into the dark chamber during retentiontrials mean value ± standard error (unit: seconds) Vehicle only group286.7 ± 13.3 (n = 6) β-amyloid protein (1-42) 191.7 ± 49.0 (n = 6) 300pmol/day group β-amyloid protein (1-42) 300.0 ± 0.0  (n = 5) 300pmol/day and test compound 12 fmol/day group

The time taken to move into the dark chamber was extended for the testcompound group when compared to the β-amyloid protein(1–42) only group.In other words, in the present experiment, the test compound displayedan activity to ameliorate learning and memory deficit.

EXAMPLE 48 Measurement of the Ameliorating Effect on Learning and MemoryDeficit (5)

Test compound:(1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

The ameliorating effect on learning and memory deficit was evaluatedwith the evaluation methods of Reference examples 19 and 20. The testcompound was dissolved in the β-amyloid protein solution, and injectedat the same time as the β-amyloid protein, using an osmotic pump. Theresults are shown in Table 17 below.

TABLE 17 Occurrence of spontaneous alternation behavior mean value ±standard error (unit: %) β-amyloid protein (40-1) 72.2 ± 2.9 (n = 6) 300pmol/day group β-amyloid protein (1-42) 65.6 ± 3.4 (n = 6) 300 pmol/daygroup β-amyloid protein (1-42) 74.1 ± 2.5 (n = 6) 300 pmol/day and testcompound 12 fmol/day group

The occurrence of spontaneous alternation behavior increased for thetest compound group when compared to the β-amyloid protein(1–42) onlygroup. In other words, in the present experiment, the test compounddisplayed an activity to ameliorate learning and memory deficit.

EXAMPLE 49 Measurement of the Ameliorating Effect on Learning and MemoryDeficit (6)

Test compound:(1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

The ameliorating effect on learning and memory deficit was evaluatedwith the evaluation methods of Reference examples 19 and 20. The testcompound was dissolved in the β-amyloid protein solution, and injectedat the same time as the β-amyloid protein, using an osmotic pump. Theresults are shown in Table 18 below.

TABLE 18 Occurrence of spontaneous alternation behavior mean value ±standard error (unit: %) β-amyloid protein (40-1) 76.3 ± 4.9 (n = 6) 300pmol/day group β-amyloid protein (1-42) 66.5 ± 4.7 (n = 6) 300 pmol/daygroup β-amyloid protein (1-42) 72.1 ± 3.7 (n = 6) 300 pmol/day and testcompound 12 fmol/day group

The occurrence of spontaneous alternation behavior increased for thetest compound group when compared to the β-amyloid protein(1–42) onlygroup. In other words, in the present experiment, the test compounddisplayed an activity to ameliorate learning and memory deficit.

EXAMPLE 50 Measurement of the Ameliorating Effect on Learning and MemoryDeficit (7)

Test compound:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

The ameliorating effect on learning and memory deficit was evaluatedwith the evaluation methods of Reference examples 19 and 20. The testcompound was dissolved in the β-amyloid protein solution, and injectedat the same time as the β-amyloid protein, using an osmotic pump. Theresults are shown in Table 19 below.

TABLE 19 Occurrence of spontaneous alternation behavior mean value ±standard error (unit: %) β-amyloid protein (40-1) 76.3 ± 4.9 (n = 6) 300pmol/day group β-amyloid protein (1-42) 66.5 ± 4.7 (n = 6) 300 pmol/daygroup β-amyloid protein (1-42) 73.2 ± 5.1 (n = 6) 300 pmol/day and testcompound 12 fmol/day group

The occurrence of spontaneous alternation behavior increased for thetest compound group when compared to the β-amyloid protein(1–42) onlygroup. In other words, in the present experiment, the test compounddisplayed an activity to ameliorate learning and memory deficit.

EXAMPLE 51

Measurement of the Ameliorating Effect on Learning and Memory Deficit 8)

Test compound:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

The ameliorating effect on learning and memory deficit was evaluatedwith the evaluation methods of Reference examples 19 and 20. The testcompound was dissolved in the β-amyloid protein solution, and injectedat the same time as the β-amyloid protein, using an osmotic pump. Theresults are shown in Table 20 below.

TABLE 20 Occurrence of spontaneous alternation behavior mean value ±standard error (unit: %) Vehicle only group 68.2 ± 2.3 (n = 6) β-amyloidprotein (1-42) 59.1 ± 3.0 (n = 6) 300 pmol/day group β-amyloid protein(1-42) 71.7 ± 4.0 (n = 6) 300 pmol/day and test compound 12 fmol/daygroup

The occurrence of spontaneous alternation behavior increased for thetest compound group when compared to the β-amyloid protein(1–42) onlygroup. In other words, in the present experiment, the test compounddisplayed an activity to ameliorate learning and memory deficit.

EXAMPLE 52 Evaluation of the Promotion Activity on the Neurite Outgrowth(1)

Test compound:(1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

The promotion activity on the neurite outgrowth was evaluated with themethod of Reference example 21.

In addition to the test compound, PGE₁, whose promotion activity on theneurite outgrowth is known in other neuroblastoma cell strain (Miki etal., Drugs and treatments, Vol. 21, No.1, p93), was administered to anadditional group for comparison. The results are shown in Table 21below.

TABLE 21 Proportion of cells with neurite (%) Compound mean value ±standard error Test compound not added  8.8 ± 1.3 PGE₁ (10 nM) 26.0 ±3.0 Test compound (10 nM) 40.3 ± 3.5

This experiment shows that a promotion activity on the neurite outgrowthwas detected for the test compound (level of significance: p<0.01). Inaddition, test compound showed a strong promotion activity when comparedto PGE₁ which is known to have a promotion activity on the neuriteoutgrowth (level of significance: p<0.05).

EXAMPLE 53 Evaluation of the Promotion Activity on the Neurite Outgrowth(2)

Test compound:(1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

The promotion activity on the neurite outgrowth was evaluated with themethod of Reference example 22.

In addition to the test compound, as in Example 52, PGE₁ wasadministered to an additional group for comparison. The results areshown in Table 22 below.

TABLE 22 Length of neurite per single cell (pixel/cell) Compound meanvalue ± standard error Test compound not added  6.1 ± 0.9 PGE₁ (1 nM)14.2 ± 1.5 Test compound (1 nM) 22.6 ± 3.0

This experiment shows that a promotion activity on the neurite outgrowthwas detected for the test compound level of significance: p<0.01). Inaddition, test compound showed a strong promotion activity when comparedto PGE₁ which is known to have a promotion activity on the neuriteoutgrowth (level of significance: p<0.05).

EXAMPLE 54 Evaluation of the Promotion Activity on the Neurite Outgrowth(3)

Test compound:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The promotion activity on the neurite outgrowth was evaluated with themethod of Reference example 21.

In addition to the test compound, as in Example 52, PGE₁ wasadministered to an additional group for comparison. The results areshown in Table 23 below.

TABLE 23 Proportion of cells with neurite (%) Compound mean value ±standard error Test compound not added  6.1 ± 0.9 PGE₁ (10 nM) 19.5 ±1.9 Test compound (10 nM) 38.7 ± 6.6

This experiment shows that a promotion activity on the neurite outgrowthwas detected for the test compoundlevel of significance: p<0.01). Inaddition, test compound showed a strong promotion activity when comparedto PGE₁ which is known to have a promotion activity on the neuriteoutgrowth (level of significance: p<0.05).

EXAMPLE 55

Evaluation of the Promotion Activity on the Neurite Outgrowth (4)

Test compound:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene

The promotion activity on the neurite outgrowth was evaluated with themethod of Reference example 22.

In addition to the test compound, as in Example 52, PGE, wasadministered to an additional group for comparison. The results areshown in Table 24 below.

TABLE 24 Length of neurite per single cell (pixel/cell) Compound meanvalue ± standard error Test compound not added 1.2 ± 0.13 PGE₁ (100 nM)5.7 ± 1.03 Test compound (100 nM) 8.0 ± 1.37

This experiment shows that a promotion activity on the neurite outgrowthwas detected for the test compound.(level of significance: p<0.01).

EXAMPLE 56 Evaluation of the Promotion Activity on the Neurite Outgrowth(5)

Test compound A:(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3S,1E)-3-hydroxy-4-methyl-1-octene-6-ynyl]-5-(4-N,N-dimethylaminobutyl)-1H-cyclopenta[b]benzofuran.

Test compound B:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Test compound C:(1S,2R,3R,5S)-7-[(E)-5-N,N-dimethylaminopentylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyne-1-enyl]-3-hydroxybicyclo[3.3.0]octane.

Test compound D:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(3S,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Test compound E:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The promotion activity on the neurite outgrowth was evaluated with themethod of Reference example 21.

In parallel to the test compounds, as in Example 52, PGE₁ wasadministered to an additional group for comparison. The results areshown in Table 25 below.

TABLE 25 Promotion activity on the Concentration of test neuriteoutgrowth Compound compound (μM) (value relative to PGE₁) Vehicle — 0.79PGE₁ 10 1.00 Test compound A 10 1.17 Test compound B 10 1.63 Testcompound C 10 1.15 Test compound D 10 1.31 Test compound E 10 1.58

EXAMPLE 57 Evaluation of the Promotion Activity on the NeurneuriteOutgrowth (6)

Test compound A:(1S,5S,6R,7R)-3-(5-morpholinopentyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Test compound B:(1S,5S,6R,7R)-3-[5-N,N-diisopropylaminopentyl]-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Test compound C:(1S,5S,6R,7R)-3-[5-(1-pyrrolidinyl)pentyl]-6-[(3R,1E)-3-hydroxy-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The promotion activity on the neurneurite outgrowth was evaluated usingthe method of Reference example 21.

In parallel to the test compounds, as in Example 52, PGE₁ wasadministered to an additional group for comparison. The results areshown in Table 26 below.

TABLE 26 Promotion activity on the Concentration of neurite outgrowthCompound compound (μM) (value relative to PGE1) Vehicle — 0.45 PGE₁ 101.00 Test compound A 10 1.15 Test compound B 0.1 1.12 Test compound C 101.25

EXAMPLE 58 Evaluation of the Promotion Activity on the NeurneuriteOutgrowth (7)

Test compound A:(1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Test compound B:(1S,5S,6R,7R)-3-(4-N,N-dimethylcarbamoylbutyl)-6-[(E)-4-(m-tolyl)-1-butenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The promotion activity on the neurneurite outgrowth was evaluated withthe method of Reference example 21.

In parallel to the test compounds, as in Example 52, PGE₁ wasadministered to an additional group for comparison. The results areshown in Table 27 below.

TABLE 27 Promotion activity on the Concentration of neurite outgrowthCompound compound (μM) (value relative to PGE1) Vehicle — 0.53 PGE₁ 101.00 Test compound A 10 1.39 Test compound B 10 1.50

EXAMPLE 59 Measurement of the Blood Pressure Decreasing Activity (1)

Test compound:(1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The effect on the blood pressure was evaluated with the method ofReference example 23. The variation in the blood pressure afteradministration of the test compound was as indicated in Table 28 below.

TABLE 28 Blood pressure (values normalized to 100 at 0 minute) Dose (±standard error) mg/kg 0 min 3 min 5 min 10 min 15 min 30 min 60 minSolvent only 0 100 98.4 97.5 102.6 100.6 102.2 98.8 (2.0) (0.9) (2.3)(1.1) (4.8) (3.6) Test compound 0.1 100 102.2 101.1 100.0 101.5 97.3101.1 (1.0) (0.4) (1.9) (1.9) (1.9) (2.8) Solvent only 0 100 101.8 99.298.5 100.0 99.8 97.0 (1.1) (0.5) (1.5) (1.2) (1.7) (1.2) Test compound 1100 93.7 95.7 101.0 100.9 101.1 104.8 (5.6) (5.7) (4.8) (3.2) (2.0)(3.2)

In the 1 mg/Kg group, the test compound exerted a decrease in bloodpressure immediately after administration. However, it was observed thatrecovery was fast, only a slight decrease existed after 3 minutes, andafter 10 minutes, the blood pressure returned to normal values. Nosignificant variations were observed in the 0.1 mg/Kg group. In otherwords, it is clear that the test compound is a compound having anextremely small activity on the circulatory system.

EXAMPLE 60 Measurement of the Blood Pressure Decreasing Activity (2)

Test compound:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

The effect on the blood pressure was evaluated with the method ofReference example 23. The variation in the blood pressure afteradministration of the test compound was as indicated in Table 28 below.

TABLE 29 Blood pressure (values normalized to 100 at 0 minute) Dose (±standard error) mg/kg 0 min 3 min 5 min 10 min 15 min 30 min 60 minSolvent only 0 100 101.1 99.7 103.7 105.2 101.4 98.3 (0.8) (1.8) (3.0)(3.2) (3.0) (2.7) Test compound 0.1 100 100.8 99.7 102.1 101.7 101.2101.5 (2.2) (2.9) (1.7) (2.8) (1.3) (3.7) Solvent only 0 100 101.7 98.597.8 98.7 98.2 94.0 (1.0) (1.1) (1.0) (1.5) (2.8) (3.5) Test compound 1100 108.1 105.1 105.9 105.9 105.0 99.9 (1.6) (1.1) (0.8) (1.8) (1.8)(2.5)

In other words, it is clear that, since no significant variations wereobserved in the 0.1 mg/Kg dose and the 1 mg/Kg dose, the test compoundis a compound having an extremely small activity on the circulatorysystem.

EXAMPLE 61 Measurement of the Permeability Through the Blood BrainBarrier (1)

Test compound A:(1S,5S,6R,7R)-3-(4-carbamoylbutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Test compound B:(1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Permeability through the blood brain barrier was measured with themethod of Reference example 24. As a reference, measurements were alsoperformed for the well-known isocarbacyclin derivative (test compoundB), and compared. The results are shown in Table 30 below.

TABLE 30 Rate of incorporation into bovine capillary endothelialCompound cells (mean value of two experiments) Test compound A 5.09%Test compound B below detection limit

It is clear from this experiment that the test compound has a highpermeability through the blood brain barrier.

EXAMPLE 62

Measurement of the Permeability Through the Blood Brain Barrier (2)

Test compound A:(1S,5S,6R,7R)-3-(5-N,N-dimethylaminopentyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Test compound B:(1S,5S,6R,7R)-3-(4-carboxybutyl)-6-[(4S,1E)-4-hydroxy-4-methyl-1-octenyl]-7-hydroxybicyclo[3.3.0]-2-octene.

Permeability through the blood brain barrier was measured with themethod of Reference example 24. As a reference, measurements were alsoperformed for the well-known isocarbacyclin derivative (test compoundB), and compared. The results are shown in Table 31 below.

TABLE 31 Rate of incorporation into bovine capillary endothelialCompound cells (mean value of two experiments) Test compound A 15.8%Test compound B below detection limit

In other words, it is clear that the test compound A has a highpermeability through the blood brain barrier.

USABILITY IN THE INDUSTRY

The nitrogen-containing compound of the present invention represented bythe above equation (1) has an activity for the remedy of nerve damage.Therefore, the compound of the present invention can be used as atherapeutic agent for diorders due to nerve damage or nerve lesions dueto external injuries.

1. A nitrogen-containing compound represented by Formula (2) shown belowor a salt thereof:

In Formula (2), the symbol

represents a single bond or a double bond G represents one functionalgroup chosen from the group consisting of the Formulae (G1), (G2), (G3),(G4) and (G5) shown below:

(In Formula (G 1), Formula (G2), Formula (G3), Formula (G4) and Formula(G5), the symbol

represents the site of linkage with A¹⁰; R⁴ represents a hydrogen atom,an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon grouphaving 1 to 7 carbon atoms) silyl group or a functional group formingthe acetal bond together with the oxygen atom bonded to R⁴; W representsa single bond, —CH₂—, —(CH₂)₂—, —(CH₂)₃—, —CH═CH—, —CH═CHCH₂—, —C═C—of—C═CCH₂—; m may be either 0 or 1, however, when W is a single bond, m isequal to 1; R⁵ and R⁶ are either identical or different and, eitherrepresent one functional group chosen from the following items 1) to4): 1) a hydrogen atom, 2) a substituted or an unsubstituted aliphatichydrocarbon group having 1 to 10 carbon atoms, when the substituents areselected from the group consisting of: fluorine atom, chlorine atom,bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy grouphaving 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms,sulfonyloxy group having 1 to 8 carbon atoms, oxo group, carboxyl group,alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylaminogroup having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8carbon atoms, imino group having 1 to 10 carbon atoms, cyano group,nitro group, sulfide group having 1 to 6 carbon atoms, sulfinyl grouphaving 1 to 6 carbon atoms, and sulfonyl group having 1 to 6 carbonatoms, substituted or unsubstituted alicyclic hydrocarbon group having 3to 8 carbon atoms, wherein the substituents are selected from the groupconsisting of: aliphatic hydrocarbon group having 1 to 6 carbon atoms,fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy grouphaving 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbonatoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxylgroup, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl grouphaving 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms,acylamino group having 1 to 10 carbon atoms, sulfonylamino group having1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyanogroup, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinylgroup having 1 to 6 carbon atoms, and sulfonyl group having 1 to 6carbon atoms, and substituted or unsubstituted aromatic hydrocarbongroup having 6 to 10 carbon atoms, wherein the substituents are selectedfrom the group consisting of: alkyl group having 1 to 4 carbon atoms,fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy grouphaving 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbonatoms, acyl group having 1 to 10 carbon atoms, carboxyl group,alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl group having1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms, acylaminogroup having 1 to 10 carbon atoms, sulfonylamino group having 1 to 8carbon atoms, cyano group, nitro group, sulfide group having 1 to 6carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and sulfonylgroup having 1 to 6 carbon atoms, 3) a substituted or an unsubstitutedalicyclic hydrocarbon group having 3 to 8 carbon atoms wherein thesubstituents are selected from the group consisting of alkyl grouphaving 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom,iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms,aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxygroup having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbonatoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms,sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and sulfonylgroup having 1 to 6 carbon atoms, 4) a substituted or an unsubstitutedaromatic hydrocarbon group having 6 to 10 carbon atoms, wherein thesubstituents are selected from the group consisting of alkyl grouphaving 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromine atom,iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms,aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxygroup having 1 to 8 carbon atoms, acyl group having 1 to 10 carbonatoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylaminogroup having 1 to 8 carbon atoms, cyano group, nitro group, sulfidegroup having 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbonatoms, and sulfonyl group having 1 to 6 carbon atoms, or, when R⁵ and R⁶are bonded to each other, they represent a substituted or anunsubstituted alicyclic hydrocarbon chain having 4 to 7 carbon atomswherein the substituents are selected from the group consisting of alkylgroup having 1 to 4 carbon atoms, fluorine atom, chlorine atom, bromineatom, iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbonatoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy group having7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms,sulfonyloxy group having 1 to 8 carbon atoms, oxo group, acyl grouphaving 1 to 10 carbon atoms, carboxyl group, alkoxycarbonyl group having2 to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, aminogroup having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbonatoms, sulfonylamino group having 1 to 8 carbon atoms, imino grouphaving 1 to 10 carbon atoms, cyano group, nitro group, sulfide grouphaving 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms,and, sulfonyl group having 1 to 6 carbon atoms; R⁷ represents a hydrogenatom, an acyl group having 2 to 10 carbon atoms, a tri(hydrocarbon grouphaving 1 to 7 carbon atoms) silyl group, an alkoxycarbonyl group having2 to 5 carbon atoms, a sulfonyl group having 1 to 8 carbon atoms, afunctional group forming the acetal bond together with the oxygen atombound to R⁷, or, when R⁷ and R⁵ are bonded to each other, it representsone portion of the bond forming the carbonyl group together with thecarbon atom bonded to R⁵ and the oxygen atom bonded to R⁷; A²⁰represents a single bond, a Formula (A2A) shown below, a Formula (A2B)shown below or a Formula (A2C) shown below:

(in the formula, R³ represents a hydrogen atom, an alkyl group having 1to 4 carbon atoms, or an acyl group having 1 to 10 carbon atoms)

(in the formula, n represents 0, 1, or 2) A¹⁰ represents the items 1) or2) below: 1) a single bond, 2) a functional group which bridges G andA²⁰ through an identical atom or through different atoms, and chosenfrom: an aliphatic hydrocarbon group having 1 to 3 carbon atoms, analicyclic hydrocarbon group having 3 to 8 carbon atoms, a heterocyclicgroup selected from the group consisting of morpholino, pyrrolidinyl,and piperidino, and a phenylene group; A³⁰ represents the items 1) or 2)below: 1) a single bond, 2) a functional group which bridges A²⁰ and A⁴⁰through an identical atom or through different atoms, and chosen from:an aliphatic hydrocarbon group having 1 to 3 carbon atoms, an alicyclichydrocarbon group having 3 to 8 carbon atoms, a heterocyclic groupselected from the group consisting of morpholino, pyrrolidinyl, andpiperidino, and a phenylene group; A⁴⁰ represents any of the items 1) to3) below: 1) a single bond, 2) an aliphatic hydrocarbon group having 1to 3 carbon atoms, which bridges the nitrogen atom, bonded to R¹⁰ andR²⁰, and A³⁰ through an identical atom or through different atoms; 3)when A⁴⁰ and R¹⁰ are bonded to each other, a functional group forming a5 to 8 membered ring together with the nitrogen atom they are bonded to(when A⁴⁰ or R¹⁰ and the nitrogen atom they are bonded to are bondedthrough a double bond, R²⁰ represents the bond between A⁴⁰ or R¹⁰ andthe nitrogen atom); however, in the combination of G, A¹⁰, A²⁰, A³⁰, andA⁴⁰, when G represents the Formula (G1) and either of A¹⁰ or A³⁰ is aphenylene group, A²⁰ may not be a single bond and when A²⁰ represents asingle bond, then G and the nitrogen atom bonded to R¹⁰ and R²⁰ must bebonded with more than two carbon atoms in between; in addition, when A²⁰represents one of the Formula (A2A), Formula (A2B) or Formula (A2C), A²⁰and the nitrogen atom bonded to R¹⁰ and R²⁰ must be bonded with morethan two carbon atoms in between; R¹⁰ and R²⁰ are either identical ordifferent, and either represents one functional group chosen from thefollowing items 1) to 7): 1) a hydrogen atom (however, when R¹⁰ and R²⁰both represent a hydrogen atom, only in the case where G is equal toFormula (G1)), 2) a substituted or an unsubstituted alkyl group having 1to 10 carbon atoms, wherein the substituents are selected from the groupconsisting of fluorine atom, chlorine atom, bromine atom, iodine atom,hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy grouphaving 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to8 carbon atoms, oxo group, carboxyl group, alkoxycarbonyl group having 2to 10 carbon atoms, carbamoyl group having 1 to 15 carbon atoms, aminogroup having 0 to 14 carbon atoms, acylamino group having 1 to 10 carbonatoms, sulfonylamino group having 1 to 8 carbon atoms, imino grouphaving 1 to 10 carbon atoms, cyano group, nitro group, sulfide grouphaving 1 to 6 carbon atoms, sulfinyl group having 1 to 6 carbon atoms,sulfonyl group having 1 to 6 carbon atoms, cycloalkyl group having 3 to8 carbon atoms, and phenyl group, 3) a substituted or an unsubstitutedcycloalkyl group having 3 to 8 carbon atoms, wherein the substituentsare selected from the group consisting of alkyl group having 1 to 4carbon atoms, fluorine atom, chlorine atom, bromine atom, iodine atom,hydroxyl group, alkoxy group having 1 to 4 carbon atoms, aryloxy grouphaving 6 to 10 carbon atoms, aralkoxy group having 7 to 9 carbon atoms,acyloxy group having 2 to 10 carbon atoms, sulfonyloxy group having 1 to8 carbon atoms, oxo group, an acyl group having 1 to 10 carbon atoms,carboxyl group, alkoxycarbonyl group having 2 to 10 carbon atoms,carbamoyl group having 1 to 15 carbon atoms, amino group having 0 to 14carbon atoms, acylamino group having 1 to 10 carbon atoms, sulfonylaminogroup having 1 to 8 carbon atoms, imino group having 1 to 10 carbonatoms, cyano group, nitro group, sulfide group having 1 to 6 carbonatoms, sulfinyl group having 1 to 6 carbon atoms, and sulfonyl grouphaving 1 to 6 carbon atoms, 4) a substituted or an unsubstituted phenylgroup, wherein the substituents are selected from the group consistingof alkyl group having 1 to 4 carbon atoms, fluorine atom, chlorine atom,bromine atom, iodine atom, hydroxyl group, alkoxy group having 1 to 4carbon atoms, aryloxy group having 6 to 10 carbon atoms, aralkoxy grouphaving 7 to 9 carbon atoms, acyloxy group having 2 to 10 carbon atoms,sulfonyloxy group having 1 to 8 carbon atoms, acyl group having 1 to 10carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbonatoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms,sulfonylamino group having 1 to 8 carbon atoms, cyano group, nitrogroup, sulfide group having 1 to 6 carbon atoms, sulfinyl group having 1to 6 carbon atoms, and sulfonyl group having 1 to 6 carbon atoms, 5) asubstituted or an unsubstituted heterocyclic group selected from thegroup consisting of morpholino, pyrrolidinyl, and piperidino and, alkylgroup having 1 to 4 carbon atoms, wherein the substituents are selectedfrom the group consisting of fluorine atom, chlorine atom, bromine atom,iodine atom, hydroxyl group, alkoxy group having 1 to 4 carbon atoms,aryloxy group having 6 to 10 carbon atoms, aralkoxy group having 7 to 9carbon atoms, acyloxy group having 2 to 10 carbon atoms, sulfonyloxygroup having 1 to 8 carbon atoms, oxo group, acyl group having 1 to 10carbon atoms, carboxyl group, alkoxycarbonyl group having 2 to 10 carbonatoms, carbamoyl group having 1 to 15 carbon atoms, amino group having 0to 14 carbon atoms, acylamino group having 1 to 10 carbon atoms,sulfonylamino group having 1 to 8 carbon atoms, imino group having 1 to10 carbon atoms, cyano group, nitro group, sulfide group having 1 to 6carbon atoms, sulfinyl group having 1 to 6 carbon atoms, and sulfonylgroup having 1 to 6 carbon atoms, 6) an acyl group having 1 to 10 carbonatoms, 7) a sulfonyl group having 1 to 8 carbon atoms; however, wheneither R¹⁰ or R²⁰ represents a sulfonyl group having 1 to 8 carbonatoms, the other may neither be an acyl group having 1 to 10 carbonatoms nor a sulfonyl group having 1 to 8 carbon atoms, or, when R¹⁰ andR²⁰ are bonded together, they represent a functional group forming acyclic amino group having 4 to 8 carbon atoms together with the nitrogenatom they are bonded to, wherein said cyclic amino group having 4 to 8carbon atoms may be substituted with one or more substituents selectedfrom the group consisting of alkyl group having 1 to 4 carbon atoms,fluorine atom, chlorine atom, bromine atom, iodine atom, hydroxyl group,alkoxy group having 1 to 4 carbon atoms, aryloxy group having 6 to 10carbon atoms, aralkoxy group having 7 to 9 carbon atoms, acyloxy grouphaving 2 to 10 carbon atoms, sulfonyloxy group having 1 to 8 carbonatoms, oxo group, acyl group having 1 to 10 carbon atoms, carboxylgroup, alkoxycarbonyl group having 2 to 10 carbon atoms, carbamoyl grouphaving 1 to 15 carbon atoms, amino group having 0 to 14 carbon atoms,acylamino group having 1 to 10 carbon atoms, sulfonylamino group having1 to 8 carbon atoms, imino group having 1 to 10 carbon atoms, cyanogroup, nitro group, sulfide group having 1 to 6 carbon atoms, sulfinylgroup having 1 to 6 carbon atoms, and sulfonyl group having 1 to 6carbon atoms.
 2. A nitrogen-containing compound or a salt thereof ofclaim 1, wherein G in the above Formula (2) is one functional groupchosen from the group consisting of the Formulae (G1E), (G2E), (G3E),(G4E), and (G5E) shown below:

In the above Formula (G1E), Formula (G2E), Formula (G3E), Formula (G4E)and Formula (G5E), the symbol

indicates that the bond is in the β position with respect to the carbonatom forming the cyclic structure it is bonded to, and the symbol

indicates that the bonds are in the a position with respect to thecarbon atoms forming the cyclic structures they are bonded to.
 3. Anitrogen-containing compound or a salt thereof of claim 1, wherein G inthe above Formula (2) is a functional group having the Formula (G1). 4.A nitrogen-containing compound or a salt thereof of claim 2, wherein Gin the above Formula (2) is a functional group having the Formula (G1E).5. A nitrogen-containing compound or a salt thereof of claim 2, whereinG in the above Formula (2) is one functional group chosen from the groupconsisting of the above Formulae (G2E), (G3E), (G4E) and (G5E).
 6. Anitrogen-containing compound of a salt thereof of claim 2, wherein G inthe above Formula (2) is a functional group having the Formula (G3E).